A prospective multi-centre, open study of the safety and efficacy of hylan G-F 20 (Synvisc®) in patients with symptomatic ankle (talo-crural) osteoarthritis

Foot and Ankle Surgery

Volumn 14, Issue 3, 2008, Pages 145-152

  Witteveen, Angelique G H ^a   Giannini, Sandro ^b   Guido, Giulio ^c   Jerosch, Joerg ^d   Lohrer, Heinz ^e   Vannini, Francesca ^b   Donati, Leonardo ^c   Schulz, Axel ^a,d   Scholl, Jakob ^e   Sierevelt, Inger N ^a   van Dijk, C Niek ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d JOHANNA ETIENNE KRANKENHAUS   (Germany)

^e Sportmedizinisches Institut   (Germany)

Author keywords

Ankle; Hyaluronan; Hylan G F 20; Osteoarthritis; Viscosupplementation

Indexed keywords

ACETYLSALICYLIC ACID; CORTICOSTEROID; HYALURONIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ADULT; ALLERGIC DISEASE; ANALGESIA; ANKLE; ARTHRALGIA; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HUMAN; INJECTION SITE PAIN; JOINT SWELLING; MALE; MULTICENTER STUDY; OSTEOARTHRITIS; OSTEOCHONDRITIS DISSECANS; PRIORITY JOURNAL; SKIN DISEASE; VISUAL ANALOG SCALE; X RAY;

ADULT; ANKLE JOINT; FEMALE; HUMANS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; MALE; MIDDLE AGED; OSTEOARTHRITIS; PAIN MEASUREMENT; PROSPECTIVE STUDIES; QUALITY OF LIFE; VISCOSUPPLEMENTS;

EID: 48849094992     PISSN: 12687731     EISSN: 14609584     Source Type: Journal    
DOI: 10.1016/j.fas.2008.01.001     Document Type: Article

References (23)

1. Buckwalter J.A., Saltzman C., and Brown T. The impact of osteoarthritis. Clin Orthop Relat Res Suppl. 427 (2004) S6-S15
2. Cushnaghan J., and Dieppe P. Study of 500 patients with limb joint osteoarthritis. I. Analysis by age, sex, and distribution of symptomatic joint sites. Ann Rheum Dis 50 (1991) 8-13
3. Saltzman C.L., Salamon M.L., Blanchard G.M., Huff T., Hayes A., Buckwalter J.A., et al. Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopedic center. Iowa Orthop J 25 (2005) 44-46
4. Agel J., Coetzee J.C., Sangeorzan B.J., Roberts M.M., and Hansen Jr. S.T. Functional limitations of patients with end-stage ankle arthrosis. Foot Ankle Int 26 (2005) 537-539
5. van Dijk C.N., Tol J.L., and Verheyen C.C. A prospective study of prognostic factors concerning the outcome of arthroscopic surgery for anterior ankle impingement. Am J Sports Med 25 (1997) 737-745
6. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and the knee: 2000 update. Arthritis Rheum 43 (2000) 1905-1915
7. Pendleton A., Arden N., Dougados M., Doherty M., Bannwarth B., Bijlsma J.W., et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies including Therapeutic Trials (ESCISIT). Ann Rheum Dis 59 (2000) 936-944
8. Pelletier J.P., and Martel-Pelletier J. The pathophysiology of osteoarthritis and the implication of the use of hyaluronan and hylan as therapeutic agents in viscosupplementation. J Rheumatol Suppl 39 (1993) 19-24
9. Weiss C., and Band P. Musculoskeletal applications of hyaluronan and hylan. Potential uses in the foot and ankle. Clin Podiatr Med Surg 12 (1995) 497-517
10. Salk R.S., Chang T.J., D'Costa W.F., Soomekh D.J., and Grogan K.A. Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study. J Bone Joint Surg Am 88 (2006) 295-302
11. Sun S.F., Chou Y.J., Hsu C.W., Hwang C.W., Hsu P.T., Wang J.L., et al. Efficacy of intra-articular hyaluronic acid in patients with osteoarthritis of the ankle: a prospective study. Osteoarthritis Cartilage 14 (2006) 867-874
12. Conrozier T., Bertin P., Mathieu P., Charlot J., Bailleul F., Treves R., et al. Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: an open-label, multicentre, pilot study. Clin Exp Rheumatol 21 (2003) 605-610
13. Migliore A., Tormenta S., Martin Martin L.S., Iannessi F., Massafra U., Carloni E., et al. The symptomatic effects of intra-articular administration of hylan G-F 20 on osteoarthritis of the hip: clinical data of 6 months follow-up. Clin Rheumatol 25 (2006) 389-393
14. van Dijk, CN. Ankle joint arthroscopy. In: Surgical techniques in orthopaedics and traumatology. Editions Scientifiques et Médicales Elsevier SAS (Paris), 2001: 1-6.
15. Domsic R.T., and Saltzman C.L. Ankle osteoarthritis scale. Foot Ankle Int 19 (1998) 466-471
16. Kemper F., Gebhardt U., Meng T., and Murray C. Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice. Curr Med Res Opin 21 (2005) 1261-1269
17. Synvisc Product Label (USA).
18. Kelly M.A., Kurzweil P.R., and Moskowitz R.W. Intra-articular hyaluronans in knee osteoarthritis: rationale and practical considerations. Am J Orthop 33 (2004) 15-22
19. Hyalgan Study Group, Altman R.D., and Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a 1 year placebo-controlled trial. J Rheumatol 25 (1998) 2203-2212
20. Brandt K.D., Block J.A., Michalski J.P., Moreland L.W., Caldwell J.R., and Lavin P.T. Efficacy and safety of intraarticular sodium hyaluronate in knee osteoarthritis. ORTHOVISC Study Group. Clin Orthop Relat Res 385 (2001) 130-143
21. Dougados M., Nguyen M., Listrat V., and Amor B. High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial. Osteoarthritis Cartilage 1 (1993) 97-103
22. Henderson E.B., Smith E.C., Pegley F., and Blake D.R. Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy. Ann Rheum Dis 53 (1994) 529-534
23. Bagga H., Burkhardt D., Sambrook P., and March L. Long term effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol 33 (2006) 946-950