CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 9, 2002, Pages 2981-2985

  Tsukamoto, Sachiko ^a   Tomise, Kyoko ^a   Miyakawa, Keiko ^a   Cha, Bae Cheon ^a   Abe, Takamasa ^b   Hamada, Toshiyuki ^b,c   Hirota, Hiroshi ^b,c   Ohta, Tomihisa ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DIPIPERAMIDE D; DIPIPERAMIDE E; DRUG METABOLITE; DRUG METABOLIZING ENZYME; UNCLASSIFIED DRUG; ALKALOID; CINNAMIC ACID DERIVATIVE; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; ENZYME INHIBITOR; PIPERIDINE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG METABOLISM; DRUG POTENCY; ENZYME INHIBITION; HUMAN; IC 50; NUCLEAR OVERHAUSER EFFECT; PEPPER; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; BIOAVAILABILITY; BLACK PEPPER; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE; STEREOISOMERISM;

PIPER NIGRUM;

ALKALOIDS; BIOLOGICAL AVAILABILITY; BLACK PEPPER; CINNAMATES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PIPER NIGRUM; PIPERIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036311050     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00130-X     Document Type: Article

References (17)