Enhancement of dissolution of nystatin from buccoadhesive tablets containing various surfactants and a solid dispersion formulation

Archives of Pharmacal Research

Volumn 33, Issue 11, 2010, Pages 1771-1779

  Sakeer, Khalil ^a   Al Zein, Hind ^a   Hassan, Issa ^a   Desai, Sandip ^b   Nokhodchi, Ali ^b,c  

^a Department of Pharmaceutics and Pharmaceutical Technology   (Lebanon)

^b MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Buccoadhesive tablets; Drug release; Nystatin; Solid dispersion; Solid state

Indexed keywords

CREMOPHOR; LACTOSE; NYSTATIN; POLYSORBATE 80; XANTHAN;

ARTICLE; DRUG INDICATION; DRUG RELEASE; DRUG SOLUBILITY; MOUTH INFECTION; MYCOSIS; TABLET FORMULATION;

ADHESIVENESS; ADMINISTRATION, BUCCAL; ANTIFUNGAL AGENTS; DRUG COMPOUNDING; EXCIPIENTS; HUMANS; LACTOSE; NYSTATIN; POLYMERS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TABLETS;

EID: 78751543654     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-1109-1     Document Type: Article

References (22)

1. Akbari, J., Nokhodchi, A., Farid, D., Adrangui, M., Siahi-Shadbad, M. R., and Saeedi, M., Development and evalua-tion of buccoadhesive propranolol hydrochloride tablet for-mulations: effect of fillers. Farmaco, 59, 155-161 (2004).
2. Andersen., T., Gram-Hansen, M., Pedersen, M., and Rassing, M. R., Chewing gum as a drug delivery system for nystatin influence of solubilising agents upon the release of water insoluble drugs. Drug Dev. Ind. Pharm., 16, 1985-1994 (1990).
3. Berko, S., Regdon, G., Ducza, E., Falkay, G., and Ero, I., In vitro and in vivo study in rats of rectal suppositories containing furosemide. Eur. J. Pharm. Biopharm., 53, 311-315 (2002).
4. Chen, J. L. and Cyr, G. N., In: Manly, R. S. (Ed.), Composition producing adhesion through hydration, Adhesion in Biological System, Academic press, New York, pp. 163-181, (1970).
5. Choi, H. G. and Kim, C K., Development of omeprazole buccal adhesive tablets with stability enhancement in human saliva. J. Control. Release, 68, 397-404 (2000).
6. Codd, J. E. and Deasy, P. B., Formulation development and in vivo evaluation of a novel bioadhesive lozenge contain-ing a synergistic combination of antifungal agents. Int. J. Pharm., 173, 13-24 (1998).
7. Craig, D. Q., The mechanisms of drug release from solid dispersions in water-soluble polymers. Int. J. Pharm., 231, 131-144 (2002).
8. Desai, K. G. and Kumar, T. M., Preparation and evaluation of a novel buccal adhesive system. AAPS PharmSciTech, 5, Article 35 (2004).
9. Ford, J. L., The current status of solid dispersions. Pharm. Acta Helv., 61, 69-88 (1986).
10. Hiemenz, J. W. and Walsh, T. J., Lipid formulations of amphotericin B: recent progress and future directions. Clin. Infect. Dis., 22, S133-S144 (1996).
11. Kwon, G. S. and Yoo, B. K., Nystatin formulation having reduced toxicity. http://www.freepatentsonline.com/6413537. html.03/10/2000.
12. Leuner, C. and Dressman, J., Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm. Biopharm., 50, 47-60 (2000)
13. Llabot, J. M., Manzo, R. H., and Allemandi, D. A., Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system. Int. J. Pharm., 276, 59-66 (2004).
14. Millns, B. and Martin, M. V., Nystatin pastilles and suspension in the treatment of oral candidosis. Br. Dent. J., 181, 209-211 (1996).
15. Papadopoulou, V., Kosmidis, K., Vlachou, M., and Macheras, P., On the use of the Weibull function for the discernment of drug release mechanisms. Int. J. Pharm., 309 44-50 (2006).
16. Peppas, N. A., Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv., 60, 110-111 (1985).
17. Pons, V., Greenspan, D., Lozada, N. F., McPhail, L., Gallant, J. E., Tunkel, A., Johnson, C. C, McCarty, J., Panzer, H., Levenstein, M., Barranco, A., and Green, S., Oropharyugeal candidiasis in patients with AIDS: randomized compari-son of fluconazole versus nystatin oral suspensions. Clin. Infect. Dis., 24, 1204-1207 (1997).
18. Ritger, P. L. and Peppas, N. A., A simple equation for descri-ption of solute release, II. Fickian and anomalous release from swellable devices. J. Control. Release, 5, 37-42 (1987).
19. Sakeer, K, Al-Zein, H., Hassan, I., Martin, G. P., and Nokhodchi, A., Use of a natural occurring polymer and its binary blends with synthetic polymers to design con-trolled release formulations of buccoadhesive nystatin tablets. Pharm. Dev. Technol., 15, 360-368 (2010).
20. Sriamornsak, P., Thirawong, N., and Korkerd, K., Swelling, erosion and release behavior of alginate-based matrix tablets. Eur. J. Pharm. Biopharm., 66, 435-450 (2007). (Pubitemid 46756227)
21. Tallury, P., Randall, K M., Khin, L. T., John, S. P., and Kalachandra, S., Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copoly-mer. Dent. Mater., 23, 977-982 (2007).
22. Wong, C. F., Yuen, K. H., and Peh, K. K., An in-vitro method for buccal adhesion studies: importance of instrument variables. Int. J. Pharm., 180, 47-57 (1999).