Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma

Journal of Pediatric Surgery

Volumn 46, Issue 1, 2011, Pages 108-114

  Gendy, Amir S ^a,b   Lipskar, Aaron ^a,b   Glick, Richard D ^a   Steinberg, Bettie M ^a,b   Edelman, Morris ^a   Soffer, Samuel Z ^a,b  

^a North Shore Long Island Jewish Health System ^*  (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Antiangiogenesis; COX 2 inhibitor; Ewing sarcoma; Lung metastases; mTOR inhibitor

Indexed keywords

CD99 ANTIGEN; CELECOXIB; CYCLOOXYGENASE 2; LECTIN; RAPAMYCIN;

ANGIOGENESIS; ANGIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EWING SARCOMA; FEMALE; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MONOTHERAPY; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VOLUME; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE, TUMOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG THERAPY, COMBINATION; FEMALE; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PYRAZOLES; SARCOMA, EWING'S; SIROLIMUS; SULFONAMIDES;

EID: 78751527395     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2010.09.074     Document Type: Article

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