Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions

Cancer Research

Volumn 71, Issue 2, 2011, Pages 496-505

  Towle, Murray J ^a   Salvato, Kathleen A ^a   Wels, Bruce F ^a   Aalfs, Kimberley K ^a   Zheng, Wanjun ^a   Seletsky, Boris M ^a   Zhu, Xiaojie ^a   Lewis, Bryan M ^a   Kishi, Yoshito ^b   Yu, Melvin J ^a   Littlefield, Bruce A ^a  

^a EISAI INC   (United States)

^b EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ERIBULIN; PROTEIN BCL 2;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RETENTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANTIMITOTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; FURANS; HELA CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HL-60 CELLS; HUMANS; JURKAT CELLS; KETONES; MITOSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TRITIUM; U937 CELLS;

EID: 78751525051     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1874     Document Type: Article

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