NM23 Protein expression in colorectal carcinoma using TMA (tissue microarray): Association with metastases and survival

Arquivos de Gastroenterologia

Volumn 47, Issue 4, 2010, Pages 361-367

  Oliveira, Levindo Alves De ^a   Artigiani Netoricardo, Ricardo ^a   Waisberg, Daniel Reis ^a   Fernandes, Luis Cesar ^a   Lima, Flávio De Oliveira ^a   Waisberg, Jaques ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antigens; Biological; Carcinoma; CD; Colorectal neoplasms; NM23 nucleoside diphosphate kinases; Prognosis; Tumor markers

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE NM23;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METABOLISM; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROTEIN EXPRESSION; TISSUE MICROARRAY;

EID: 78751515169     PISSN: 00042803     EISSN: 16784219     Source Type: Journal    
DOI: 10.1590/s0004-28032010000400008     Document Type: Article

References (41)

1. Andrade VP, Cunha IW, Silva EM, Ayala F, Sato Y, Ferreira S, Nascimento CF, Soares FA. O arranjo em matriz de amostras teciduais (tissue microarray): larga escala e baixo custo ao alcance do patologista. J Bras Patol Med Lab. 2007;43:55-60.
2. Anwar S, Frayling IM, Scott NA, Carlson GL. Systematic review of genetic influences on the prognosis of colorectal cancer. Br J Surg. 2004;91:1275-91.
3. Astler VB, Coller FA. The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg. 1954;139:846-52.
4. Ayhan A, Yassui W, Yokozaki H, Kitadai Y, Tahara E. Reduced expression of NM23 protein associated with advanced tumor stage and distant metastases in human colorectal carcinomas. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;63:213-8.
5. Baili P, Micheli A, De Angelis R, Weir HK, Francisci S, Santaquilani M, Hakulinen T, Quaresmas M, Coleman MP. Life tables for world-wide comparison of relative survival for cancer (CONCORD study). Tumori. 2008;94:658-68.
6. Bazan V, Migliavacca M, Zanna I, Tubiolo C, Corsale S, Calò V, Amato A, Cammareri P, Latteri F, Grassi N, Fulfaro F, Porcasi R, Morello V, Nuara RB, Dardanoni G, Salerno S, Valerio MR, Dusonchet L, Gerbino A, Gebbia N, Tomasino RM, Russo A. DNA ploidy and S-phase fraction, but not p53 or NM23-H1 expression, predict outcome in colorectal cancer patients. Result of a 5-year prospective study. J Cancer Res Clin Oncol. 2002;128:650-8.
7. Berney CR, Fisher RJ, Yang J, Russel PJ, Crowe PJ. Protein markers in colorectal cancer: predictor of liver metastasis. Ann Surg. 1999;230:179-84.
8. Berney CR, Fisher RJ, Yang J, Russel PJ, Crowe PJ. Genomic alterations (LOH, MI) on chromosome 17q21-23 and prognosis of sporadic colorectal cancer. Int J Cancer. 2000;89:1-7.
9. Boyle P. Favorable trends in cancer mortality in the European Union but no room for complacency. Ann Oncol. 2008;19:605-6.
10. Brenner AS, Thebo JS, Senagore AJ, Duepree HJ, Gramlich T, Ormsby A, Lavery IC, Fazio VW. Analysis of both NM23-H1 and NM23-H2 expression identifies "at-risk" patients with colorectal cancer. Am Surg. 2003;69:203-8.
11. Campo E, Miquel R, Jares P, Bosch F, Juan M, Leone A, Vives J, Cardesa A, Yague J. Prognostic significance of the loss of heterozygosity of NM23-H1 and p53 genes in human colorectal carcinomas. Cancer. 1994;73:2913-21.
12. Cheah PY, Cao X, Eu KW, Seow-Choen F. NM23-H1 immunostaining is inversely associated with tumour staging but not overall survival or disease recurrence in colorectal carcinomas. Br J Cancer. 1998;77:1164-8.
13. Chen WC, Lin MS, Zhang BF, Fang J, Zhou Q, Hu Y, Gao HJ. Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. World J Gastroenterol. 2007;13:699-708.
14. Cohn KH, Wang FS, Desoto-LaPaix F, Salomon WB, Patterson LG, Arnold MR, Feldman JG, Levy AT, Leone A, Steeg PS. Association of nm23 allelic deletions with distant metastases in colorectal carcinoma. Lancet. 1991;338:722-4.
15. Coleman MP, Quaresma M, Berrino F, Lutz JM, De Angelis R, Capocaccia R, Baili P, Rachet B, Gatta G, Hakulinen T, Micheli A, Sant M, Weir HK, Elwood JM, Tsukuma H, Koifman S, Silva GA, Francisci S, Santaquilani M, Verdecchia A, Storm HH, Young JL; CONCORD Working Group. Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol. 2008;9:730-56.
16. Delektorskaya VV, Perevoshchikov AG, Kushlinskii NE. Immunohistological study of nm23 and C-erB-2 expression in primary tumor and metastases of colorectal adenocarcinoma. Bull Exp Biol Med. 2003;135:489-94.
17. Demirbas S, Sücüllü I, Yildirim S, Celenk T. Influence of the c-erb B-2, nm23, Bcl-2 and p53 protein markers on colorectal cancer. Turk J Gastroenterol. 2006;17:13-9.
18. Elagoz S, Egilmez R, Koyuncu A, Muslehiddinoglu A, Arici S. The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer. Pathol Oncol Res. 2006;12:21-7.
19. Futamura M, Takagi Y, Koumura H, Kida H, Tanemura H, Shimokawa K, Saji S. Spread of colorectal cancer micrometastases in regional lymph nodes by reverse transcriptase-polymerase chain reactions for carcinoembrionic antigen and cytokeratin 20. J Surg Oncol. 1998;68:34-40.
20. Garinis GA, Manolis EN, Spanakis NE, Patrinos GP, Peros G, Menounos PG. High frequency of concomitant nm23 - H1 and E-cadherin transcriptional inactivation in primary non-inheriting colorectal carcinomas. J Mol Med. 2003;81:256-63.
21. Hadziavdic V, Eminovic I, Asceric M, Komel R. Familial adenomatous polyposis: analysis of genetic instability of microsatellites loci and genetic alternations of tumor suppressor genes. Bosn J Basic Med Sci. 2008;8:160-4.
22. Haut M, Steeg PS, Wilson JK, Markowitz SD. Induction of nm23 gene expression in human colonic neoplasms and equal expression in colon tumors of high and low metastatic potential. J Natl Cancer Inst. 1991;83:712-6.
23. Heide I, Thiede C, Poppe K, de Kant E, Huhn D, Rochlitz C. Expression and mutational analysis of Nm23-H1 in liver metastases of colorectal cancer. Br J Cancer. 1994;70:1267-71.
24. Kim HJ, Kang HJ, Lee H, Lee ST, Yu MH, Kim H, Lee C. Identification of S100A8 and S100A9 as serological markers for colorectal cancer. J Proteome Res. 2009;8:1368-79.
25. Kononen J, Budendorf L, Kallioniemmi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP. Tissue microarrays for highthroughput molecular profiling of tumor specimens. Nat Med. 1998;4:844-7.
26. Lee JC, Lin YJ Chow NH, Wang ST. Reappraisal of the role of NM-23 H1 in colorectal cancers. J Surg Oncol. 2001;76:58.
27. Lindmark G. NM23-H1 immunohistochemistry is not useful as predictor of metastatic potential of colorectal cancer. Br J Cancer. 1996;74:1413-8.
28. Liu YJ, Yan PS, Li J, Jia JF. Expression and significance of CD44s, CD44v6, and nm23 mRNA in human cancer. World J Gastroenterol. 2005;11:6601-6.
29. Lopez MJ, Monafo WW. Role of extended resection in the initial treatment of locally advanced colorectal carcinoma. Surgery. 1993;113:365-72.
30. Madbouly KM, Senagore AJ, Mukerjee A, Delaney CP, Connor J, Fazio VW. Does immunostaining effectively upstage colorectal cancer by identifying micrometastatic nodal disease? Int J Colorectal Dis. 2007;22:39-48.
31. Martinez JA, Prevot S, Nordlinger B, Nguyen TM, Lacarriere Y, Munier A, Lascu I, Vaillant JC, Capeau J, Lacombe ML. Overexpression of nm23-H1 and NM23-H2 genes in colorectal carcinomas and loss of nm23-H1 expression in advanced tumour stages. Gut. 1995;37:712-20.
32. Myeroff LL, Markowitz SD. Increased nm23-H1 and nm23-H2 messenger RNA expression and absence of mutations in colon carcinomas of low and high metastatic potential. J Natl Cancer Inst. 1993;85:147-52.
33. Nasser JA, Falavigna A, Ferraz F, Duigou G, Bruce J. Transcription analysis of TIMP-1 and NM23-h1 genes in glioma cell invasion. Arq Neuropsiquiatr. 2006;64:774-80.
34. Royds JA, Cross SS, Silcocks PB, Scholefield JH, Rees RC, Stephenson TJ. Nm23 "anti-metastatic" gene product expression in colorectal carcinoma. J Pathol. 1994;172:261-6.
35. Sarris M, Lee CS. nm23 protein expression in colorectal carcinoma metastasis in regional lymph nodes and the liver. Eur J Surg Oncol. 2001;27:170-4.
36. Silveira EJ, Oliveira MC, Morais ML, Queiroz LM, Costa AL. Expressão da proteína nm23 em carcinoma de células escamosas de língua metastático e nãometastático. Rev Bras Otorrinolaringol. 2008;74:356-9.
37. Tannapfel A, Köckerling F, Katalinic A, Wittekind C. Expression of nm23-H1 predicts lymph node involvement in colorectal carcinoma. Dis Colon Rectum. 1995;38:651-4.
38. Wang L, Patel U, Ghosh L, Chen HC, Banerjee S. Mutation in the nm23 gene is associated with metastasis in colorectal cancer. Cancer Res. 1993;53: 717-20.
39. Yamaguchi A, Urano T, Fushida S, Furukawa K, Nishimura G, Yonemura Y, Miyazaki I, Nakagawara G, Shiku H. Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis. Br J Cancer. 1993;68:1020-4.
40. Yang YQ, Wu L, Chen JX, Sun JZ, Li M, Li DM, Lu HY, Su ZH, Lin XQ, Li JC. Relationship between nm23-H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients. World J Gastroenterol. 2008;14:5549-56.
41. Yao T, Takata M, Tustsumi S, Nishiyama K, Taguchi K, Nagai E, Tsuneyoshi M. Phenotypic expression of gastrointestinal differentiation makers in colorectal adenocarcinomas with liver metastasis. Pathology. 2002;34:556-60.