Reappraisal of the role of NM23-H1 in colorectal cancers

Journal of Surgical Oncology

Volumn 76, Issue 1, 2001, Pages 58-62

  Lee, Jenq Chang ^a   Lin, Yih Jyn ^a   Chow, Nan Haw ^a   Wang, Shan Tair ^a  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Carcinogenesis; Colorectal cancer; Immunohistochemical study; Liver metastasis; nm23 H1 gene

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE A; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

COLORECTAL NEOPLASMS; DISEASE PROGRESSION; HEALTH STATUS INDICATORS; HUMANS; IMMUNOHISTOCHEMISTRY; MONOMERIC GTP-BINDING PROTEINS; NEOPLASM STAGING; NUCLEOSIDE-DIPHOSPHATE KINASE; PROGNOSIS; TRANSCRIPTION FACTORS;

EID: 0035141427     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9098(200101)76:1<58::AID-JSO1010>3.0.CO;2-D     Document Type: Article

References (21)

1. Evidence for a novel gene associated with low tumor metastatic potential
2. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinoma with lymph node involvement and other histopathological indicators of high metastatic potential
3. Suppressive role of the metastasis-related nm23-H1 gene in human ovarian carcinoma: Association of high messenger RNA expression with lack of lymph node metastasis
4. NM23-H1 protein immunoreactivity in laryngeal carcinoma
5. Levels of nm23 messenger RNA in metastatic malignant melanomas: Inverse correlation to disease progression
6. Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product
7. Reduced expression of nm23 is associated with metastasis of human gastric carcinoma
8. Association of nm23-H1 allelic deletions with distant metastasis in colorectal carcinoma
9. Mutation in the nm23 gene is associated with metastasis in colorectal cancer
10. Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis
11. Overexpression of nm23-H1 and nm23-H2 gene in colorectal carcinoma and loss of NM23-H1 expression in advanced tumor stages
12. Expression of nm23-H1 predicts lymph node involvement in colorectal carcinoma
13. Induction of nm23 expression in human colonic neoplasms and equal expression in colon of high and low metastatic potential
14. Increased nm23-H1 and nm23-H2 messenger RNA expression and absence of mutations in colon carcinomas of low and high metastatic potential
15. Expression and mutational analysis of nm23-H1 in liver metastasis of colorectal cancer
16. The nm23 gene and colorectal cancer
17. NM23-H1 immunohistochemistry is not useful as predictor of metastatic potential of colorectal cancer
18. Prognostic significance of direct extension of carcinoma of colon and rectum
19. Altered expression of nm23-H1 and c -erb B-2 proteins have prognostic significance in adenocarcinoma but not in squamous cell carcinoma of the uterine cervix