High frequency of concomitant nm23-H1 and E-cadherin transcriptional inactivation in primary non-inheriting colorectal carcinomas

Journal of Molecular Medicine

Volumn 81, Issue 4, 2003, Pages 256-263

  Garinis, George A ^a,d,e   Manolis, Evangelos N ^b   Spanakis, Nick E ^c   Patrinos, George P ^e   Peros, George ^c   Menounos, Panayiotis G ^a  

^a Nursing Military Academy   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c Nikaia Hospital   (Greece)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

E cadherin; Nm 23 H1; SCRC; Transcription

Indexed keywords

BIOLOGICAL MARKER; RNA; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INHIBITION; CANCER INVASION; CANCER STAGING; COHORT ANALYSIS; COLORECTAL CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE SILENCING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; NM23 H1 GENE; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; SUPPRESSOR GENE; TRANSCRIPTION INITIATION; TUMOR GROWTH;

EID: 0037569467     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-003-0420-4     Document Type: Article

References (29)

1. Killion JJ, Fdler IJ (1989) The biology of tumor metastasis. Semin Oncol 16:105-115
2. Kohn EC, Liotta L (1993) Invasion and metastasis: new approaches to an old problem. Oncology 7:47-62
3. Strackle ML, Liotta LA (1995) Molecular mechanism of tumor cell metastasis. In: Mendelsohn J, Howley P, Israel A, Liotta LA (eds) The molecular basis of cancer-. Saunders, Philadelphia, pp 223-247
4. Steeg PS, Bevilacqua G, Kopper L, Thogeirsson UP, Talmadge JE, Liotta LA, Sobel ME (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80:200-204
5. Varesco L, Caligon MA, Simi P, Black DM, Nardimi V, Casarino L, Rocchi M, Ferrara G, Solomon E, Bevilacqua G (1992) The nm23 gene maps to human chromosome band 17q22 ans shows a restriction fragment length polymorphism with Bg1II. Genes Chromosomes Cancer 4:84-88
6. Nakayama T, Ohtsuru A, Nakao K, Shima M, Nakata K, Watanabe K, Ishii N, Kimura N, Nagataki S (1992) Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. J Natl Cancer Inst 84:1349-1354
7. Yamaguchi A, Urano T, Goi T, Takeuchi K, Niimoto S, Nakagawara G, Furukawa K, Shiku H (1994) Expression of human nm23-H1 and nm23-H2 proteins in hepatocellular carcinoma. Cancer 73:2280-2284
8. Royds JA, Stephenson TJ, Rees RC, Shorthouse AJ, Silcocks PB (1993) Nm23 protein expression in ductal in situ and invasive human breast carcinoma. J Natl Cancer Inst 85:727-731
9. Kodera Y, Isobe K, Yamauchi M, Kondoh K, Kimura N, Akiyama S, Itoh K, Nakashima I, Takagi H (1994) Expression of nm23 H-1 RNA levels in human gastric cancer tissues. A negative correlation with nodal metastasis. Cancer 73:259-265
10. Tokunaga Y, Urano T, Furukawa K, Kondo H, Kanematsu T, Shiku H (1993) Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer. Int J Cancer 55:66-71
11. Ayhan A, Yasui W, Yokozaki H, Kitadai Y, Tahara E (1993) Reduced expression of nm23 protein is associated with advanced tumor stage and distant metastases in human colorectal carcinomas. Virchows Arch B Cell Pathol 63:213-218
12. Tannapfel A, Kockerling F, Katalinic A, Wittekind C (1995) Expression of nm23-H1 predicts lymph node involvement in colorectal carcinoma. Dis Colon Rectum 38:651-654
13. Haut M, Steeg PS, Willson JK, Markowitz SD (1991) Induction of nm23 gene expression in human colonic neoplasms and equal expression in colon tumors of high and low metastatic potential. J Natl Cancer Inst 83:712-716
14. Heide I, Thiede C, Poppe K, de Kant E, Huhn D, Rochlitz C (1994) Expression and mutational analysis of Nm23-H1 in liver metastases of colorectal cancer. Br J Cancer 70:1267-1271
15. Myeroff LL, Markowitz SD (1993) Increased nm23-H1 and nm23-H2 messenger RNA expression and absence of mutations in colon carcinomas of lowand high metastatic potential. J Natl Cancer Inst 85:147-152
16. Lee JC, Lin YJ, Chow NH, Wang ST (2001) Reappraisal of the role of NM23-H1 in colorectal cancers. J Surg Oncol 76:58-62
17. Takeichi M (1995) Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 7:619-627
18. Wijnhoven BP, Pignatelli M (1999) E-cadherin-catenin: more than a "sticky" molecular complex. Lancet 354:356-357
19. Christofori G, Semb H (1999) The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 24:73-76
20. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S (1995) Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 92:7416-7419
21. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ (2000) E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 92:569-573
22. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392:190-193
23. Garinis GA, Menounos PG, Spanakis NE, Papadopoulos K, Karavitis G, Parassi I, Christeli E, Patrinos GP, Manolis EN, Peros G (2002) Hypermethylation-associated transcriptional silencing of E-cadherin in primary sporadic colorectal carcinomas. J Pathol 198:442-449
24. Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W, Sugimura T, Hirohashi S (1994) E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci USA 91:1858-1862
25. Ilyas M, Tomlinson IP, Hanby A, Talbot IC, Bodmer WF (1997) Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers. Gut 40:654-659
26. Wheeler JM, Kim HC, Efstathiou JA, Ilyas M, Mortensen NJ, Bodmer WF (2001) Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut 48:367-371
27. Hartsough MT, Clare SE, Mair M, Elkahloun AG, Sgroi D, Osborne K, Clark G, Steeg P (2001) Elevation of breast carcinoma nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition. Cancer Res 61:2320-2327
28. Heimann R, Lan F, McBride R, Hellman S (2000) Separating favourable from unfavourable prognostic markers in breast cancer: the role of E-cadherin. Cancer Res 60:298-304
29. Palacios F, Schweitzer JK, Boshans RL, D'Souza-Schorey C (2002) ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol 4:929-936