Kinetic and chemical mechanism of the dihydrofolate reductase from Mycobacterium tuberculosis

Biochemistry

Volumn 50, Issue 3, 2011, Pages 367-375

  Czekster, Clarissa M ^a   Vandemeulebroucke, An ^a   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MECHANISM; DIHYDROFOLATE; DIHYDROFOLATE REDUCTASE; HYDRIDE TRANSFERS; ISOTOPE EFFECT; KINETIC CHARACTERIZATION; KINETIC ISOTOPE EFFECTS; KINETIC MECHANISM; MYCOBACTERIUM TUBERCULOSIS; ONE-CARBON UNITS; PH DEPENDENCE; PH RANGE; RATE LIMITING; STEPWISE MECHANISMS; TETRAHYDROFOLATES;

CARRIER MOBILITY; EQUILIBRIUM CONSTANTS; ISOTOPES;

PH EFFECTS;

DIHYDROFOLATE REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; ENZYME KINETICS; EQUILIBRIUM CONSTANT; MYCOBACTERIUM TUBERCULOSIS; PH; PH MEASUREMENT; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; STEADY STATE;

DEUTERIUM; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; NADP; TETRAHYDROFOLATE DEHYDROGENASE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 78751501376     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1016843     Document Type: Article

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