Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors

Biochemistry

Volumn 50, Issue 3, 2011, Pages 356-366

  Lee, Geun Shik ^a   Simons, S Stoney ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST ACTIVITY; BINDING AFFINITIES; BINDING CAPACITIES; COACTIVATORS; COFACTOR BINDING; COFACTORS; DEXAMETHASONES; ELEVATED CONCENTRATIONS; ENDOGENOUS GENES; GAL4 DNA BINDING DOMAINS; GENE INDUCTION; GLUCOCORTICOID RECEPTOR; LIGAND BINDING DOMAIN; NUCLEAR TRANSLOCATIONS; POINT MUTATIONS; PROTEIN-PROTEIN INTERACTIONS; SYNTHETIC GLUCOCORTICOIDS; TRANSACTIVATION; TRANSCRIPTIONAL PROPERTIES; WILD TYPES;

BINDING ENERGY; LIGANDS;

GENES;

DEACYLCORTIVAZOL; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN UBC9; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DNA BINDING; GENE INDUCTION; LIGAND BINDING; PARTIAL AGONISM; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STEADY STATE; TRANSACTIVATION; WILD TYPE;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DEXAMETHASONE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; LIGANDS; MESYLATES; PREGNATRIENES; RECEPTORS, GLUCOCORTICOID; TRANSFECTION; UBIQUITIN-CONJUGATING ENZYMES;

EID: 78751483455     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101792d     Document Type: Article

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