Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells

Human Immunology

Volumn 70, Issue 10, 2009, Pages 785-789

  Luo, Min ^a   Simons Jr , S Stoney ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Antisteroids; Gene selective responses; Glucocorticoid hormone action; Modulation of induction parameters; Steroid potency vs. efficacy

Indexed keywords

CD163 ANTIGEN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LEUCINE ZIPPER PROTEIN; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN P160; RNA; SMALL INTERFERING RNA; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYOPRESERVATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA INTERFERENCE; THAWING; TISSUE CULTURE;

GENE EXPRESSION; GENES, REPORTER; HUMANS; LEUKOCYTES, MONONUCLEAR; NUCLEAR RECEPTOR COACTIVATOR 2; RECEPTORS, GLUCOCORTICOID; RNA, SMALL INTERFERING;

EID: 70349305108     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2009.07.029     Document Type: Article

References (19)

1. Cole T.J. Glucocorticoid action and the development of selective glucocorticoid receptor ligands. Biotechnol Annu Rev 12 (2006) 269-300
2. Kleiman A., and Tuckermann J.P. Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice. Mol Cell Endocrinol 275 (2007) 98-108
3. De Bosscher K., and Haegeman G. Minireview: latest perspectives on antiinflammatory actions of glucocorticoids. Mol Endocrinol 23 (2009) 281-291
4. Galon J., Franchimont D., Hiroi N., et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J 16 (2002) 61-71
5. John S., Sabo P.J., Johnson T.A., et al. Interaction of the glucocorticoid receptor with the chromatin landscape. Mol Cell 29 (2008) 611-624
6. Simons Jr. S.S. The importance of being varied in steroid receptor transactivation. TIPS 24 (2003) 253-259
7. Simons Jr. S.S. What goes on behind closed doors: physiological versus pharmacological steroid hormone actions. Bioessays 30 (2008) 744-756
8. Reichardt H.M., Umland T., Bauer A., Kretz O., and Schutz G. Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol Cell Biol 20 (2000) 9009-9017
9. Vottero A., Kino T., Combe H., Lecomte P., and Chrousos G.P. A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators. J Clin Endocrinol Metab 87 (2002) 2658-2667
10. Fuqua S.A., Wiltschke C., Zhang Q.X., et al. A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions. Cancer Res 60 (2000) 4026-4029
11. Wan W., Farboud B., and Privalsky M.L. Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol 19 (2005) 1529-1542
12. Visser J., Lentjes E., Haspels I., et al. Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors. J Investig Med 49 (2001) 195-204
13. Sarlis N.J., Bayly S.F., Szapary D., and Simons Jr. S.S. Quantity of partial agonist activity for antiglucocorticoids complexed with mutant glucocorticoid receptors is constant in two different transactivation assays but not predictable from steroid structure. J Steroid Biochem Mol Biol 68 (1999) 89-102
14. Voegel J.J., Heine M.J.S., Tini M., Vivat V., Chambon P., and Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J 17 (1998) 507-519
15. Kaul S., Blackford Jr. J.A., Cho S., and Simons Jr. S.S. Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. J Biol Chem 277 (2002) 12541-12549
16. Lonard D.M., and O'Malley B.W. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell 27 (2007) 691-700
17. Szapary D., Xu M., and Simons Jr. S.S. Induction properties of a transiently transfected glucocorticoid-responsive gene vary with glucocorticoid receptor concentration. J Biol Chem 271 (1996) 30576-30582
18. Wang Q., Richter W.F., Anzick S.L., Meltzer P.S., and Simons Jr. S.S. Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors. J Steroid Biochem Mol Biol 91 (2004) 197-210
19. Szapary D., Song L.N., He Y., and Simons Jr. S.S. Differential modulation of glucocorticoid and progesterone receptor transactivation. Mol Cell Endocrinol 283 (2008) 114-126