Biological activity of hydantoin derivatives on P-Glycoprotein (ABCB1) of mouse lymphoma cells

Anticancer Research

Volumn 30, Issue 12, 2010, Pages 4867-4872

  Spengler, Gabriella ^a   Evaristo, Miguel ^a   Handzlik, Jadwiga ^b   Serly, Julianna ^c   Molnár, Joseph ^c   Viveiros, Miguel ^a   Kieć Kononowicz, Katarzyna ^b   Amaral, Leonard ^a  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

ABCB1; Cancer; Hydantoin; Multidrug resistance; P glycoprotein

Indexed keywords

AD 26; AD 29; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; BS 1; DOXORUBICIN; GG 5K; HYDANTOIN DERIVATIVE; JH 36; KF 2; KK XV; LL 9; MN 3; MULTIDRUG RESISTANCE PROTEIN 1; P 3; PDPH 3; RHODAMINE 123; RW 13; RW 15B; SZ 2; SZ 7; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG ACCUMULATION; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG SCREENING; FLUOROMETRY; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ETHIDIUM; FLUOROMETRY; HUMANS; HYDANTOINS; LEUKEMIA L5178; MICE; P-GLYCOPROTEIN; RHODAMINE 123; TRANSFECTION;

EID: 78751480306     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Zhang L and Ma S: Efflux pump inhibitors: a strategy to combat P-glycoprotein and the Nor A multidrug resistance pump. Chem Med Chem 5(6): 811-822, 2010.
2. Ding C and He J: Effect of antibiotics in the environment on microbial populations. Appl Microbiol Biotechnol 57(3): 925-941,2010.
3. Gatti L, Beretta GL, Cossa G, Zunino F and Perego P: ABC transporters as potential targets for modulation of drug resistance. Mini Rev Med Chem 9(9): 1102-1112, 2009.
4. Higgins CF: Multiple molecular mechanisms for multidrug resistance transporters. Nature 446(7137): 749-757, 2007.
5. Turk D and Szakács G: Relevance of multidrug resistance in the age of targeted therapy. Curr Opin Drug Discov Devel 12(2): 246-252, 2009.
6. Lee CA, Cook JA, Reyner EL and Smith DA: P-glycoprotein related drug interactions: clinical importance and a consideration of disease states. Expert Opin Drug Metab Toxicol 6(5): 603-619,2010.
7. Thenmozhiyal JC, Wong PT and Chui WK: Anticonvulsant activity of phenylmethylenehydantoins: a structure-activity relationship study. J Med Chem 47(6): 1527-1535, 2004.
8. Dylag T, Zygmunt M, Maciag D, Handzlik J, Bednarski M, Filipek B and Kied-Kononowicz K: Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives. Eur J Med Chem 39(12): 1013-1027, 2004.
9. Rajic Z, Zore B, Raic-Malic S, Ester K, Kralj M, Pavelic K, Balzarini J, De Clercq E and Mintas M: Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity. Molecules 11(11): 837-848, 2006.
10. Kavitha CV, Nambiar M, Ananda Kumar CS, Choudhary B, Muniyappa K, Rangappa KS and Raghavan SC: Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells. Biochem Pharmacol 77(3): 348-363, 2009.
11. Kieć-Kononowicz K and Szymafiska E: Antimycobacterial activity of 5-arylidene derivatives of hydantoin. Farmaco 57(11): 909-916,2002.
12. Pastan I, Gottesman, M.M, Ueda K, Lovelace E, Rutherford AV and Willingham MC: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of Pglycoprotein in MDCK cells. Proc Natl Acad Sci USA 55: 4486-4490,1988.
13. Choi K, Frommel TO, Stern RK, Perez CF, Kriegler M, Tsuruo T and Roninson IB: Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc Natl Acad Sci USA 55: 7386-7390, 1991.
14. Viveiros M, Martins A, Paixao L, Rodrigues L, Martins M, Couto I, Fähnrich E, Kern WV and Amaral L: Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium bromide method. Int J Antimicrob Agents 31: 458-462, 2008.
15. Spengler G, Viveiros M, Martins M, Rodrigues L, Molnar J, Couto I and Amaral L: Demonstration of the activity of Pglycoprotein by a semi-automated fluorometric method. Anticancer Res 29: 2173-2177, 2009.
16. Gyémánt N, Tanaka M, Moinár P, Deli J, Mándoky L and Moinár J: Reversal of multidrug resistance of cancer cells in vitro: modification of drug resistance by selected carotenoids. Anticancer Res 26: 367-374, 2006.
17. Ferreira MJ, Duarte N, Gyémánt N, Radics R, Cherepnev G, Varga A and Moinar J: Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells. Anticancer Res 26: 3541-3546,2006.
18. Spengler G, Ramalhete C, Martins M, Martins A, Serly J, Viveiros M, Moinar J, Duarte N, Mulhovo S, Ferreira MJ and Amaral L: Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry. Anticancer Res 29: 3989-3993,2009.
19. Yang K, Tang Y and Iczkowski KA: Phenyl-methylene hydantoins alter CD44-specific ligand binding of benign and malignant prostate cells and suppress CD44 isoform expression. Am J Transl Res 2: 88-94, 2010.