메뉴 건너뛰기




Volumn 10, Issue , 2011, Pages

Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; EXENDIN (9 39); EXENDIN (9-39); GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 (7 36)AMIDE; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE 1 (7-36)AMIDE; GLUCAGON-LIKE PEPTIDE RECEPTOR; PEPTIDE FRAGMENT; PROTEIN KINASE INHIBITOR;

EID: 78651589386     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-10-6     Document Type: Article
Times cited : (39)

References (48)
  • 1
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: a physiological incretin in man
    • 10.1016/S0140-6736(87)91194-9, 2890903
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987, 2:1300-4. 10.1016/S0140-6736(87)91194-9, 2890903.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 2
    • 0027157849 scopus 로고
    • Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable
    • 10.2337/diabetes.42.5.658, 8482423
    • Orskov C, Wettergren A, Holst JJ. Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable. Diabetes 1993, 42:658-61. 10.2337/diabetes.42.5.658, 8482423.
    • (1993) Diabetes , vol.42 , pp. 658-661
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 3
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • 10.1111/j.1432-1033.1993.tb17986.x, 8100523
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993, 214:829-35. 10.1111/j.1432-1033.1993.tb17986.x, 8100523.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 4
    • 45549086826 scopus 로고    scopus 로고
    • Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
    • 10.1074/jbc.M708740200, 18287102
    • Runge S, Thogersen H, Madsen K, Lau J, Rudolph R. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem 2008, 283:11340-7. 10.1074/jbc.M708740200, 18287102.
    • (2008) J Biol Chem , vol.283 , pp. 11340-11347
    • Runge, S.1    Thogersen, H.2    Madsen, K.3    Lau, J.4    Rudolph, R.5
  • 5
    • 0037629509 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium
    • 10.1016/S0196-9781(03)00108-6, 12860201
    • Kavianipour M, Ehlers MR, Malmberg K, Ronquist G, Ryden L, Wikstrom G, et al. Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium. Peptides 2003, 24:569-78. 10.1016/S0196-9781(03)00108-6, 12860201.
    • (2003) Peptides , vol.24 , pp. 569-578
    • Kavianipour, M.1    Ehlers, M.R.2    Malmberg, K.3    Ronquist, G.4    Ryden, L.5    Wikstrom, G.6
  • 6
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • 10.1161/01.CIR.0000139339.85840.DD, 15313949
    • Nikolaidis LA, Elahi D, Hentosz T, Doverspike A, Huerbin R, Zourelias L, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004, 110:955-61. 10.1161/01.CIR.0000139339.85840.DD, 15313949.
    • (2004) Circulation , vol.110 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6
  • 7
    • 0036305993 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes
    • 10.1677/joe.0.1730465, 12065236
    • Luque MA, Gonzalez N, Marquez L, Acitores A, Redondo A, Morales M, et al. Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes. J Endocrinol 2002, 173:465-73. 10.1677/joe.0.1730465, 12065236.
    • (2002) J Endocrinol , vol.173 , pp. 465-473
    • Luque, M.A.1    Gonzalez, N.2    Marquez, L.3    Acitores, A.4    Redondo, A.5    Morales, M.6
  • 8
    • 0028042205 scopus 로고
    • Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats
    • Barragan JM, Rodriguez RE, Blazquez E. Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats. Am J Physiol 1994, 266:E459-66.
    • (1994) Am J Physiol , vol.266
    • Barragan, J.M.1    Rodriguez, R.E.2    Blazquez, E.3
  • 9
    • 0030583731 scopus 로고    scopus 로고
    • Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats
    • 10.1016/S0167-0115(96)00113-9, 8952007
    • Barragan JM, Rodriguez RE, Eng J, Blazquez E. Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats. Regul Pept 1996, 67:63-8. 10.1016/S0167-0115(96)00113-9, 8952007.
    • (1996) Regul Pept , vol.67 , pp. 63-68
    • Barragan, J.M.1    Rodriguez, R.E.2    Eng, J.3    Blazquez, E.4
  • 10
    • 38349134789 scopus 로고    scopus 로고
    • Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach"
    • 10.1152/ajpcell.00522.2007, 17989206
    • Holz GG, Heart E, Leech CA. Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach". Am J Physiol Cell Physiol 2008, 294:C4-6. 10.1152/ajpcell.00522.2007, 17989206.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Holz, G.G.1    Heart, E.2    Leech, C.A.3
  • 11
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • 10.1161/01.CIR.0000120505.91348.58, 14981009
    • Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004, 109:962-5. 10.1161/01.CIR.0000120505.91348.58, 14981009.
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6
  • 12
    • 20044367874 scopus 로고    scopus 로고
    • Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model
    • 10.1007/s10557-005-6892-4, 15883751
    • Bose AK, Mocanu MM, Carr RD, Yellon DM. Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model. Cardiovasc Drugs Ther 2005, 19:9-11. 10.1007/s10557-005-6892-4, 15883751.
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 9-11
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Yellon, D.M.4
  • 13
    • 0035980166 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes
    • 10.1161/hh1701.095716, 11532906
    • Vila Petroff MG, Egan JM, Wang X, Sollott SJ. Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res 2001, 89:445-52. 10.1161/hh1701.095716, 11532906.
    • (2001) Circ Res , vol.89 , pp. 445-452
    • Vila Petroff, M.G.1    Egan, J.M.2    Wang, X.3    Sollott, S.J.4
  • 14
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • 10.1161/CIRCULATIONAHA.107.739938, 18427132
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008, 117:2340-50. 10.1161/CIRCULATIONAHA.107.739938, 18427132.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 15
    • 67649189310 scopus 로고    scopus 로고
    • Clinical Trial Report-Liraglutide Effect and Action in Diabetes (LEAD™) trial
    • Madsbad S. Clinical Trial Report-Liraglutide Effect and Action in Diabetes (LEAD™) trial. Expert Review of Endocrinology & Metabolism 2009, 4:119-29.
    • (2009) Expert Review of Endocrinology & Metabolism , vol.4 , pp. 119-129
    • Madsbad, S.1
  • 16
    • 33749852796 scopus 로고    scopus 로고
    • Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide
    • 10.1677/joe.1.06949, 17003289
    • McClenaghan NH, Flatt PR, Ball AJ. Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. J Endocrinol 2006, 190:889-96. 10.1677/joe.1.06949, 17003289.
    • (2006) J Endocrinol , vol.190 , pp. 889-896
    • McClenaghan, N.H.1    Flatt, P.R.2    Ball, A.J.3
  • 17
    • 0027484189 scopus 로고
    • Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity
    • 10.1210/en.133.4.1685, 8404610
    • Yada T, Itoh K, Nakata M. Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity. Endocrinology 1993, 133:1685-92. 10.1210/en.133.4.1685, 8404610.
    • (1993) Endocrinology , vol.133 , pp. 1685-1692
    • Yada, T.1    Itoh, K.2    Nakata, M.3
  • 18
    • 0029648771 scopus 로고
    • ATP-sensitive potassium channel and hormone/neuropeptide
    • Sakuta H. ATP-sensitive potassium channel and hormone/neuropeptide. Nippon Naibunpi Gakkai Zasshi 1995, 71:579-86.
    • (1995) Nippon Naibunpi Gakkai Zasshi , vol.71 , pp. 579-586
    • Sakuta, H.1
  • 19
    • 0028978243 scopus 로고
    • Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1
    • 10.1074/jbc.270.30.17645, 7543091
    • Holz G, Leech CA, Habener JF. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem 1995, 270:17749-57. 10.1074/jbc.270.30.17645, 7543091.
    • (1995) J Biol Chem , vol.270 , pp. 17749-17757
    • Holz, G.1    Leech, C.A.2    Habener, J.F.3
  • 20
    • 33646795007 scopus 로고    scopus 로고
    • Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts
    • 10.1124/jpet.106.100982, 16489128
    • Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, et al. Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther 2006, 317:1106-13. 10.1124/jpet.106.100982, 16489128.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1106-1113
    • Zhao, T.1    Parikh, P.2    Bhashyam, S.3    Bolukoglu, H.4    Poornima, I.5    Shen, Y.T.6
  • 21
    • 0035746210 scopus 로고    scopus 로고
    • Glucagon-like peptide isolated from the eel intestine: effects on atrial beating
    • Uesaka T, Yano K, Sugimoto S, Ando M. Glucagon-like peptide isolated from the eel intestine: effects on atrial beating. J Exp Biol 2001, 204:3019-26.
    • (2001) J Exp Biol , vol.204 , pp. 3019-3026
    • Uesaka, T.1    Yano, K.2    Sugimoto, S.3    Ando, M.4
  • 22
    • 0036452671 scopus 로고    scopus 로고
    • Involvement of the ryanodine-sensitive Ca2+ store in GLP-1-induced Ca2+ oscillations in insulin-secreting HIT cells
    • 10.1007/s00424-002-0965-z, 12466936
    • Sasaki S, Nakagaki I, Kondo H, Hori S. Involvement of the ryanodine-sensitive Ca2+ store in GLP-1-induced Ca2+ oscillations in insulin-secreting HIT cells. Pflugers Arch 2002, 445:342-51. 10.1007/s00424-002-0965-z, 12466936.
    • (2002) Pflugers Arch , vol.445 , pp. 342-351
    • Sasaki, S.1    Nakagaki, I.2    Kondo, H.3    Hori, S.4
  • 23
    • 0035886966 scopus 로고    scopus 로고
    • CAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells
    • 10.1111/j.1469-7793.2001.0375c.xd, 2278885, 11600673
    • Kang G, Chepurny OG, Holz GG. cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells. J Physiol 2001, 536:375-85. 10.1111/j.1469-7793.2001.0375c.xd, 2278885, 11600673.
    • (2001) J Physiol , vol.536 , pp. 375-385
    • Kang, G.1    Chepurny, O.G.2    Holz, G.G.3
  • 24
    • 2142805775 scopus 로고    scopus 로고
    • Gastric pacing for morbid obesity: plasma levels of gastrointestinal peptides and leptin
    • 10.1038/oby.2003.195, 14694209
    • Cigaina V, Hirschberg AL. Gastric pacing for morbid obesity: plasma levels of gastrointestinal peptides and leptin. Obes Res 2003, 11:1456-62. 10.1038/oby.2003.195, 14694209.
    • (2003) Obes Res , vol.11 , pp. 1456-1462
    • Cigaina, V.1    Hirschberg, A.L.2
  • 25
    • 0030933304 scopus 로고    scopus 로고
    • Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes
    • 10.1073/pnas.94.8.4182, 20596, 9108126
    • Xiao YF, Gomez AM, Morgan JP, Lederer WJ, Leaf A. Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc Natl Acad Sci USA 1997, 94:4182-7. 10.1073/pnas.94.8.4182, 20596, 9108126.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4182-4187
    • Xiao, Y.F.1    Gomez, A.M.2    Morgan, J.P.3    Lederer, W.J.4    Leaf, A.5
  • 26
    • 34748821105 scopus 로고    scopus 로고
    • Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice
    • 10.1124/mol.107.035881, 2243182, 17652182
    • Ke Q, Xiao YF, Bradbury JA, Graves JP, Degraff LM, Seubert JM, et al. Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice. Mol Pharmacol 2007, 72:1063-73. 10.1124/mol.107.035881, 2243182, 17652182.
    • (2007) Mol Pharmacol , vol.72 , pp. 1063-1073
    • Ke, Q.1    Xiao, Y.F.2    Bradbury, J.A.3    Graves, J.P.4    Degraff, L.M.5    Seubert, J.M.6
  • 27
    • 0020693764 scopus 로고
    • Calcium channel modulation by neurotransmitters, enzymes and drugs
    • 10.1038/301569a0, 6131381
    • Reuter H. Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 1983, 301:569-74. 10.1038/301569a0, 6131381.
    • (1983) Nature , vol.301 , pp. 569-574
    • Reuter, H.1
  • 28
    • 0028297589 scopus 로고
    • Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
    • McDonald TF, Pelzer S, Trautwein W, Pelzer DJ. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 1994, 74:365-507.
    • (1994) Physiol Rev , vol.74 , pp. 365-507
    • McDonald, T.F.1    Pelzer, S.2    Trautwein, W.3    Pelzer, D.J.4
  • 29
    • 0035661773 scopus 로고    scopus 로고
    • Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases
    • Keef KD, Hume JR, Zhong J. Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases. Am J Physiol Cell Physiol 2001, 281:C1743-56.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Keef, K.D.1    Hume, J.R.2    Zhong, J.3
  • 30
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • 10.2337/db08-1193, 2661586, 19151200
    • Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009, 58:975-83. 10.2337/db08-1193, 2661586, 19151200.
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3    Sadi, A.M.4    Zhou, Y.Q.5    Riazi, A.M.6
  • 31
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • 10.2337/diabetes.54.1.146, 15616022
    • Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005, 54:146-51. 10.2337/diabetes.54.1.146, 15616022.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 32
    • 34548545405 scopus 로고    scopus 로고
    • Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway
    • 10.1007/s10557-007-6030-6, 17541736
    • Bose AK, Mocanu MM, Carr RD, Yellon DM. Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway. Cardiovasc Drugs Ther 2007, 21:253-6. 10.1007/s10557-007-6030-6, 17541736.
    • (2007) Cardiovasc Drugs Ther , vol.21 , pp. 253-256
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Yellon, D.M.4
  • 33
    • 0027933317 scopus 로고
    • Regulation of insulin secretion: the role of second messengers
    • 10.1007/BF00400823, 7821737
    • Howell SL, Jones PM, Persaud SJ. Regulation of insulin secretion: the role of second messengers. Diabetologia 1994, 37(Suppl 2):S30-5. 10.1007/BF00400823, 7821737.
    • (1994) Diabetologia , vol.37 , Issue.SUPPL 2
    • Howell, S.L.1    Jones, P.M.2    Persaud, S.J.3
  • 34
    • 50449094096 scopus 로고    scopus 로고
    • Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells
    • 10.1085/jgp.200810044, 2518727, 18695009
    • Ramos LS, Zippin JH, Kamenetsky M, Buck J, Levin LR. Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol 2008, 132:329-38. 10.1085/jgp.200810044, 2518727, 18695009.
    • (2008) J Gen Physiol , vol.132 , pp. 329-338
    • Ramos, L.S.1    Zippin, J.H.2    Kamenetsky, M.3    Buck, J.4    Levin, L.R.5
  • 35
    • 0028840091 scopus 로고
    • A novel insulin secretagogue is a phosphodiesterase inhibitor
    • 10.2337/diabetes.44.1.67, 7813816
    • Leibowitz MD, Biswas C, Brady EJ, Conti M, Cullinan CA, Hayes NS, et al. A novel insulin secretagogue is a phosphodiesterase inhibitor. Diabetes 1995, 44:67-74. 10.2337/diabetes.44.1.67, 7813816.
    • (1995) Diabetes , vol.44 , pp. 67-74
    • Leibowitz, M.D.1    Biswas, C.2    Brady, E.J.3    Conti, M.4    Cullinan, C.A.5    Hayes, N.S.6
  • 36
    • 0033553547 scopus 로고    scopus 로고
    • CAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)
    • 10.1074/jbc.274.20.14147, 10318832
    • Holz GG, Leech CA, Heller RS, Castonguay M, Habener JF. cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem 1999, 274:14147-56. 10.1074/jbc.274.20.14147, 10318832.
    • (1999) J Biol Chem , vol.274 , pp. 14147-14156
    • Holz, G.G.1    Leech, C.A.2    Heller, R.S.3    Castonguay, M.4    Habener, J.F.5
  • 37
    • 0037073717 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells
    • 10.1074/jbc.M209165200, 12364324
    • Gomez E, Pritchard C, Herbert TP. cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells. J Biol Chem 2002, 277:48146-51. 10.1074/jbc.M209165200, 12364324.
    • (2002) J Biol Chem , vol.277 , pp. 48146-48151
    • Gomez, E.1    Pritchard, C.2    Herbert, T.P.3
  • 38
    • 0028908994 scopus 로고
    • Glucagon-like peptide-1 modulates Ca2+ current but not K+ATP current in intact mouse pancreatic B-cells
    • 10.1006/bbrc.1995.1149, 7857285
    • Britsch S, Krippeit-Drews P, Lang F, Gregor M, Drews G. Glucagon-like peptide-1 modulates Ca2+ current but not K+ATP current in intact mouse pancreatic B-cells. Biochem Biophys Res Commun 1995, 207:33-9. 10.1006/bbrc.1995.1149, 7857285.
    • (1995) Biochem Biophys Res Commun , vol.207 , pp. 33-39
    • Britsch, S.1    Krippeit-Drews, P.2    Lang, F.3    Gregor, M.4    Drews, G.5
  • 39
    • 0030695029 scopus 로고    scopus 로고
    • GLP-I(7-36) amide augments Ba2+ current through L-type Ca2+ channel of rat pancreatic beta-cell in a cAMP-dependent manner
    • 10.2337/diabetes.46.11.1755, 9356022
    • Suga S, Kanno T, Nakano K, Takeo T, Dobashi Y, Wakui M. GLP-I(7-36) amide augments Ba2+ current through L-type Ca2+ channel of rat pancreatic beta-cell in a cAMP-dependent manner. Diabetes 1997, 46:1755-60. 10.2337/diabetes.46.11.1755, 9356022.
    • (1997) Diabetes , vol.46 , pp. 1755-1760
    • Suga, S.1    Kanno, T.2    Nakano, K.3    Takeo, T.4    Dobashi, Y.5    Wakui, M.6
  • 40
    • 0035723503 scopus 로고    scopus 로고
    • Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes
    • 10.1046/j.1365-2796.2001.00862.x, 11454146
    • Gutniak MK, Svartberg J, Hellstrom PM, Holst JJ, Adner N, Ahren B. Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes. J Intern Med 2001, 250:81-7. 10.1046/j.1365-2796.2001.00862.x, 11454146.
    • (2001) J Intern Med , vol.250 , pp. 81-87
    • Gutniak, M.K.1    Svartberg, J.2    Hellstrom, P.M.3    Holst, J.J.4    Adner, N.5    Ahren, B.6
  • 41
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • 10.1056/NEJM199205143262003, 1348845
    • Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 1992, 326:1316-22. 10.1056/NEJM199205143262003, 1348845.
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Holst, J.J.3    Ahren, B.4    Efendic, S.5
  • 42
    • 0031983559 scopus 로고    scopus 로고
    • The ethanol augmentation of glucose-induced insulin secretion is abolished by calcium antagonism with nifedipine: no evidence for a role of glucagon-like peptide-1 (GLP-1)
    • 10.1097/00006676-199801000-00011, 9436865
    • Svartberg J, Holst JJ, Gutniak M, Adner N. The ethanol augmentation of glucose-induced insulin secretion is abolished by calcium antagonism with nifedipine: no evidence for a role of glucagon-like peptide-1 (GLP-1). Pancreas 1998, 16:66-71. 10.1097/00006676-199801000-00011, 9436865.
    • (1998) Pancreas , vol.16 , pp. 66-71
    • Svartberg, J.1    Holst, J.J.2    Gutniak, M.3    Adner, N.4
  • 43
    • 0033381349 scopus 로고    scopus 로고
    • Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice
    • Ahren B, Pacini G. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. Am J Physiol 1999, 277:E996-E1004.
    • (1999) Am J Physiol , vol.277
    • Ahren, B.1    Pacini, G.2
  • 44
    • 70350452572 scopus 로고    scopus 로고
    • Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1
    • 10.1124/jpet.109.158519, 2775263, 19710366
    • Jacobo SM, Guerra ML, Hockerman GH. Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1. J Pharmacol Exp Ther 2009, 331:724-32. 10.1124/jpet.109.158519, 2775263, 19710366.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 724-732
    • Jacobo, S.M.1    Guerra, M.L.2    Hockerman, G.H.3
  • 45
    • 78149493266 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure
    • 10.1186/1475-2840-9-76, 2996354, 21080957
    • Liu Q, Anderson C, Broyde A, Polizzi C, Fernandez R, Baron A, et al. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. Cardiovasc Diabetol 2010, 9:76. 10.1186/1475-2840-9-76, 2996354, 21080957.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 76
    • Liu, Q.1    Anderson, C.2    Broyde, A.3    Polizzi, C.4    Fernandez, R.5    Baron, A.6
  • 46
    • 77955106477 scopus 로고    scopus 로고
    • The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats
    • 10.1186/1475-2840-9-32, 2922097, 20678234
    • Liu Q, Adams L, Broyde A, Fernandez R, Baron AD, Parkes DG. The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats. Cardiovasc Diabetol 2010, 9:32. 10.1186/1475-2840-9-32, 2922097, 20678234.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 32
    • Liu, Q.1    Adams, L.2    Broyde, A.3    Fernandez, R.4    Baron, A.D.5    Parkes, D.G.6
  • 47
    • 78449267308 scopus 로고    scopus 로고
    • Exendin-4 protects oxidative stress-induced beta-cell apoptosis through reduced JNK and GSK3beta activity
    • 10.3346/jkms.2010.25.11.1626, 2967000, 21060752
    • Kim JY, Lim DM, Moon CI, Jo KJ, Lee SK, Baik HW, et al. Exendin-4 protects oxidative stress-induced beta-cell apoptosis through reduced JNK and GSK3beta activity. J Korean Med Sci 2010, 25:1626-32. 10.3346/jkms.2010.25.11.1626, 2967000, 21060752.
    • (2010) J Korean Med Sci , vol.25 , pp. 1626-1632
    • Kim, J.Y.1    Lim, D.M.2    Moon, C.I.3    Jo, K.J.4    Lee, S.K.5    Baik, H.W.6
  • 48
    • 79851507714 scopus 로고    scopus 로고
    • Novel glucagon-like peptide-1 analog delivered orally reduces postprandial glucose excursions in porcine and canine models
    • Eldor R, Kidron M, Greenberg-Shushlav Y, Arbit E. Novel glucagon-like peptide-1 analog delivered orally reduces postprandial glucose excursions in porcine and canine models. J Diabetes Sci Technol 2010, 4:1516-23.
    • (2010) J Diabetes Sci Technol , vol.4 , pp. 1516-1523
    • Eldor, R.1    Kidron, M.2    Greenberg-Shushlav, Y.3    Arbit, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.