Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice

Molecular Pharmacology

Volumn 72, Issue 4, 2007, Pages 1063-1073

  Ke, Qingen ^a   Xiao, Yong Fu ^a,c   Bradbury, J Alyce ^b   Graves, Joan P ^b   Degraff, Laura M ^b   Seubert, John M ^b,d   Zeldin, Darryl C ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c MEDTRONIC INC   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; CYTOCHROME P450; CYTOCHROME P450 2J2; EPOXYICOSATRIENOIC ACID; ICOSANOID; MESYLIC ACID DERIVATIVE; MONOCLONAL ANTIBODY; N METHYLSULFONYL 6 (2 PROPARGYLOXYPHENYL)HEXANAMIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL ISOLATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE OVEREXPRESSION; HEART MUSCLE CELL; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT; TRANSGENIC MOUSE; WILD TYPE;

8,11,14-EICOSATRIENOIC ACID; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ACTION POTENTIALS; AMIDES; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HEART; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; OXYGENASES; POTASSIUM;

EID: 34748821105     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.035881     Document Type: Article

References (40)

1. 2+ stores. FASEB J 6:786-792.
2. Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, and Sweatt JD (2000) Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem 275:5337-5346.
3. Brand-Schieber E, Falck JF, and Schwartzman M (2000) Selective inhibition of arachidonic acid epoxidation in vivo. J Physiol Pharmacol 51:655-672.
4. Campbell WB, Gebremedhin D, Pratt PF, and Harder DR (1996) Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78:415-423.
5. Carroll MA, Doumad AB, Li J, Cheng MK, Falck JR, and McGiff JC (2006) Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway. Am J Physiol Renal Physiol 291:F155-F161.
6. Chen J, Capdevila JH, Zeldin DC, and Rosenberg RL (1999) Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids. Mol Pharmacol 55:288-295.
7. Gelboin HV, Shou M, Goldfarb I, Yang TJ, and Krausz K (1998) Monoclonal antibodies to cytochromes P450. Methods Mol Biol 107:227-237.
8. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P, Jr., Yeager M, and Gottlieb RA (2004) Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A 101:1321-1326.
9. Gross ER, Nithipatikom K, Hsu AK, Peart JN, Falck JR, Campbell WB, and Gross GJ (2004) Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. J Mol Cell Cardiol 37:1245-1249.
10. Imig JD (2005) Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases. Am J Physiol Renal Physiol 289:F496-F503.
11. Krausz KW, Goldfarb I, Yang TJ, Gonzalez FJ, and Gelboin HV (2000) An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys. Xenobiotica 30:619-625.
12. Lee HC, Lu T, Weintraub NL, VanRollins M, Spector AA, and Shibata EF (1999) Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. J Physiol 519:153-168.
13. + channels in coronary smooth muscle through a guanine nucleotide binding protein. Circ Res 80:877-884.
14. + channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. J Physiol 537:811-827.
15. Lu T, VanRollins M, and Lee HC (2002) Stereospecific activation of cardiac ATP-sensitive K(+) channels by epoxyeicosatrienoic acids: a structural determinant study. Mol Pharmacol 62:1076-1083.
16. Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, and Lee HC (2006) Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol 575:627-644.
17. Moffat MP, Ward CA, Bend JR, Mock T, Farhangkhoee P, and Karmazyn M (1993) Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. Am J Physiol 264:H1154-H1160.
18. + channel diversity in the mammalian myocardium. J Physiol 525:285-298.
19. Nithipatikom K, DiCamelli RF, Kohler S, Gumina RJ, Falck JR, Campbell WB, and Gross GJ (2001) Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. Anal Biochem 292:115-124.
20. Nithipatikom K, Moore JM, Isbell MA, Falck JR, and Gross GJ (2006) Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. Am J Physiol Heart Circ Physiol 291:H537-H542.
21. s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem 276:15983-15989.
22. Perchenet L and Kreher P (1995) Mechanical and electrophysiological effects of preconditioning in isolated ischemic/reperfused rat hearts. J Cardiovasc Pharmacol 26:831-840.
23. Roman RJ (2002) P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82:131-185.
24. Sanada S, Kitakaze M, Papst PJ, Asanuma H, Node K, Takashima S, Asakura M, Ogita H, Liao Y, Sakata Y, et al. (2001) Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. Circulation 104:705-710.
25. 2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry. Cell Calcium 13:553-564.
26. + channels and p42/p44 MAPK pathway. Circ Res 95:506-514.
27. Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, et al. (2006) Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res 99:442-450.
28. Seubert JM, Zeldin DC, Nithipatikom K, and Gross GJ (2007) Role of epoxyeicosa-trienoic acids in protecting the myocardium following ischemia/reperfusion injury. Prostaglandins Other Lipid Mediat 82:50-59.
29. Steenbergen C, Perlman ME, London RE, and Murphy E (1993) Mechanism of preconditioning. Ionic alterations. Circ Res 72:112-125.
30. Thum T and Borlak J (2000) Gene expression in distinct regions of the heart. Lancet 355:979-983.
31. Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, et al. (2005) Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97:908-915.
32. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, and Schwartzman ML (1998) Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther 284:966-973.
33. Wu S, Chen W, Murphy E, Gabel S, Tomer KB, Foley J, Steenbergen C, Falck JR, Moomaw CR, and Zeldin DC (1997). Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem 272:12551-12559.
34. Wu S, Moomaw CR, Tomer KB, Falck JR, and Zeldin DC (1996) Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem 271:3460-3468.
35. + channel activities by epoxyeicosatrienoic acids. Prostaglandins Other Lipid Mediat 82:11-18.
36. 2+ channels and contraction in mammalian heart cells. J Physiol 508:777-792.
37. 2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2. Mol Pharmacol 66:1607-1616.
38. Xu H, Li H, and Nerbonne JM (1999) Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 alpha subunit. J Physiol 519:11-21.
39. Yao Z, Cavero I, and Gross GJ (1993) Activation of cardiac KATP channels: an endogenous protective mechanism during repetitive ischemia. Am J Physiol 264:H495-H504.
40. Zeldin DC (2001) Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem 276:36059-36062.