Defined plant extracts can protect human cells against combined xenobiotic effects

Journal of Occupational Medicine and Toxicology

Volumn 6, Issue 1, 2011, Pages

  Gasnier, Céline ^a   Laurant, Claire ^b   Decroix Laporte, Cécile ^b   Mesnage, Robin ^a   Clair, Emilie ^a   Travert, Carine ^a   Séralini, Gilles Eric ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b Sevene Pharma ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ADJUVANT; ARCTIUM LAPPA EXTRACT; ATRAZINE; BERBERIS VULGARIS EXTRACT; CAPSELLA BURSA PASTORIS EXTRACT; CARDUUS MARIANUS EXTRACT; CHELIDONIUM EXTRACT; CIRC1 PROTEIN; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DIG1 PROTEIN; DIG2 PROTEIN; GLUTATHIONE TRANSFERASE; GLYPHOSATE; HERBICIDE; PLANT EXTRACT; PULSATILLA VULGARIS EXTRACT; RAPHANUS SATIVUS EXTRACT; RHAMNUS FRANGULA EXTRACT; RUMEX CRISPUS EXTRACT; SAMBUCUS NIGRA EXTRACT; SOLIDAGO VIRGAUREA EXTRACT; SP1 PROTEIN; SPIREA ULMARIA EXTRACT; SUCCINATE DEHYDROGENASE; SURFACE WATER; TARAXACUM OFFICINALIS EXTRACT; UNCLASSIFIED DRUG; URO1 PROTEIN; XENOBIOTIC AGENT;

ARTICLE; BIOCHEMICAL COMPOSITION; CELL DISRUPTION; CELL PROTECTION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DRUG DETOXIFICATION; EMBRYO; ENZYME ACTIVITY; FOOD; HUMAN; HUMAN CELL; LIVER CELL; LIVER PROTECTION; MITOCHONDRION;

EID: 78651534995     PISSN: None     EISSN: 17456673     Source Type: Journal    
DOI: 10.1186/1745-6673-6-3     Document Type: Article

References (51)

1. IFEN: Report on pesticides in waters: Data 2003-2004. Institut Français de l'Environnement, Orléans, France; 2006:5:15-20, Dossier.
2. Takahashi M, Horie M, Aoba N: Analysis of glyphosate and its metabolite, aminomethylphosphonic acid, in agricultural products by HPLC. Shokuhin Eiseigaku Zasshi 2001, 42:304-308. (Pubitemid 33041737)
3. Spiroux de Vendômois J, Roullier F, Cellier D, Séralini GE: A comparison of the effects of three GM corn varieties on mammalian health. Int. J. Biol. Sci 2009, 5:706-726.
4. Williams GM, Kroes R, Munro IC: Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for human. Regul. Toxicol. Pharmacol 2000, 31:117-165.
5. Richard S, Moslemi S, Sipahutar H, Benachour N, Séralini GE: Differential effects of glyphosate and Roundup on human placental cells and aromatase. Environ. Health Perspec 2005, 113:716-720. (Pubitemid 40862183)
6. Benachour N, Moslemi S, Sipahutar H, Séralini GE: Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol. Appl. Pharmacol 2007, 222:129-140.
7. Benachour N, Séralini GE: Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. Chem. Res. Toxicol 2009, 22:97-105.
8. Gasnier C, Dumont C, Benachour N, Clair E, Chagnon MC, Séralini GE: Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicol 2009, 262:184-191.
9. Gasnier C, Benachour N, Clair E, Travert C, Langlois F, Laurant C, Decroix- Laporte C, Séralini GE: Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. J. Occup. Med. Toxicol 2010, 5:29-41.
10. Benachour N, Sipahutar H, Moslemi S, Gasnier C, Travert C, Séralini GE: Time- and Dose-dependent effects of Roundup on human embryonic and placental cells. Environ. Contam. Toxicol 2007, 53:126-133.
11. Urani C, Doldi M, Crippa S, Camatini M: Human-derived cell lines to study xenobiotic metabolism. Chemosphere 1998, 37:2785-2795. (Pubitemid 28522003)
12. Knasmüller S, Mersh-Sundermann V, Kevekordes S, Darroudi F, Huber WW, Hoelzl C, Bichler J, Majer BJ: Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 2004, 198:315-328. (Pubitemid 38618063)
13. Westerink WM, Schoonen WG: Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro 2007, 21:1581-1591. (Pubitemid 350103536)
14. Bu-Abbas A, Clifford MN, Walker R, Ioannides C: Contribution of caffeine and flavanols in the induction of hepatic phase II activities by green tea. Food Chem. Toxicol 1998, 36:617-621. (Pubitemid 28369888)
15. Gebhardt R: Antioxydative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Drug Res 2003, 12:823-830.
16. Hikino H, Kiso Y, Wagner H, Fiebig M: Antihepatotoxic actions of flavonolignans from Silybum marianum fruits. Planta Medica 1984, 50:248-250. (Pubitemid 14025695)
17. Lieber CS, Leo MA, Ren C, DeCarli LM: Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J. Clin. Gastroenterol 2003, 37:336-339. (Pubitemid 37158997)
18. Li RZ, Pei HP, Ji XJ: Antimutagenic activity and metabolic transformation of ranunculin by rat liver microsomes. Yao Xue Xue Bao 1993, 28:481-485.
19. Pavlica S, Gebhardt R: Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells. Free Radic. Res 2005, 39:1377-1390. (Pubitemid 43023803)
20. Banno N, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M, Watanabe K, Kimura Y, Hasagawa J, Nishino H: Triterpene acids from the leaves of Perilla fructescens and their anti-inflammatory and antitumorpromoting effects. Biosci. Biotechnol. Biochem 2004, 68:85-90.
21. Tunon H, Olavsdotter C, Bohlin L: Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. J. Ethnopharmacol 1995, 48:61-76.
22. Apati P, Szentmihalyi K, Kristo ST, Papp I, Vinkler P, Szoke E, Kery A: Herbal remedies of Solidago correlation of phytochemical characteristics and antioxydative properties. J. Pharm. Biomed. Anal 2003, 32:1045-1053.
23. Thiem B, Goslinska O: Antimicrobial activity of Solidago virgaurea L. from in vitro cultures. Fitoterapia 2002, 73:514-516. (Pubitemid 35266808)
24. Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao S, Fujiwara H: Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Medica 1999, 65:381-383. (Pubitemid 29249921)
25. Janbaz KH, Gilani AH: Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000, 71:25-33. (Pubitemid 30012013)
26. Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY: Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am. J. Chi. Med 2000, 28:163-173.
27. Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY: Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J. Biomed. Sci 2002, 9:401-409.
28. Trojanova I, Rada V, Kokoska L, Vlkova E: The bifidogenic effect of Taraxacum officinale root. Fitoterapia 2004, 75:760-763. (Pubitemid 39573481)
29. Seo SW, Koo HN, An HJ, Kwon KB, Lim BC, Seo EA, Ryu DG, Moon G, Kim HY, Kim HM, Hong SH: Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rat. World J. Gastroenterol 2005, 11:597-599.
30. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth 1983, 65:55-63.
31. Denizot F, Lang R: Rapid colorimetric assay for cell growth and survival Modification to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Meth 1986, 89:271-277. (Pubitemid 16080782)
32. Auvray P, Sourdaine P, Moslemi S, Séralini GE, Sonnet P, Enguehard C, Guillon J, Dallemagne P, Bureau R, Rault S: MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase. J. Ster. Biochem. Mol. Bio 1999>, 70:59-71.
33. Habig WH, Pabst MJ, Jacoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol Chem 1974, 249:7130-7139.
34. U.S EPA: Environmental Protection Agency: Glyphosate; notice of filing a pesticide petition to establish a tolerance for a certain pesticide chemical in or on food. Fedral Register Environment Documents 2006.
35. Galloway T, Cipelli R, Guralnick J, Ferrucci L, Bandinelli S, Corsi AM: Daily Bisphenol A Excretion and Associations with Sex Hormone Concentrations: Results from the InCHIANTI Adult Population Study. Environ Health Perspect 2010.
36. Curwin BD, Hein MJ, Barr DB, Striley C: Comparison of immunoassay and HPLC-MS/MS used to measure urinary metabolites of atrazine, metolachlor, and chlorpyrifos from farmers and non-farmers in Iowa. J Expo Sci Environ Epidemiol 2010, 20:205-12.
37. Bisphenol A: Toxic Plastics Chemical in Canned Food. [http://www.ewg.org/ reports/bisphenola].
38. Izzotti A, Kanitz S, D'Agostini F, Camoirano A, De Flora S: Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice. Mutat Res 2009, 679:28-32.
39. Casas E, Bonilla E, Ducolomb Y, Betancourt M: Differential effects of herbicides atrazine and fenoxaprop-ethyl, and insecticides diazinon and malathion, on viability and maturation of porcine oocytes in vitro. Toxicol In Vitro 2010, 24:224-30.
40. Holloway AC, Anger DA, Crankshaw DJ, Wu M, Foster WG: Atrazine-induced changes in aromatase activity in estrogen sensitive target tissues. J Appl Toxicol 2008, 28:260-70. (Pubitemid 351518113)
41. Schoonen WG, de Roos JA, Westerink WM, Débiton E: Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents. Toxicol In Vitro 2005, 19:491-503.
42. Jondeau A, Dahbi L, Bani-Estivals MH, Chagnon MC: Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants. Toxicology 2006, 226:218-228. (Pubitemid 44287171)
43. Janbaz KH, Saeed SA, Gilani AH: Protective effect og rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. Fitoterapia 2002, 73:557-563. (Pubitemid 35477750)
44. Ovesna Z, Kozics K, Slamenova D: Protective effects of ursolic acid and oleanolic acid in meukemic cells. Mutat. Res 2006, 600:131-137.
45. Mitra S, Gole M, Samadjar K, Sur RK, Chakraborty BN: Antihepatotocix activity of Chelidonium majus. Int. J. Pharmacognosy 1992, 30:125-128.
46. Biswas SJ, Bhattacharjee N, Khuda-Bukhsh AR: Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice. Food Chem. Toxicol 2007, 46:1474-1487.
47. McDanell R, McLean AEM: Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Food Chem. Toxicol 1987, 26:59-70.
48. Wiebel FJ, Lambiotte M, Singh J, Summer KH, Wolff T: Expression of carcinogen-metabolizing enzymes in continuous cultures of mammalian cells. Biochemicals Basis of Chemical Carcinogenesis, Raven Press, New York; 1984, 77-88.
49. Knasmüller S, Parzefall W, Sanyal R, Ecker S, Schwab C, Uhl M, Mersh- Sundermann V, Williamson G, Hietsch G, Langer T, Darroudi F, Natarajan AT: Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mut. Res 1998, 402:185-202. (Pubitemid 28440274)
50. Niwa T, Fujimoto M, Kishimoto K, Yabusaki Y, Ishibashi F, Katagiri M: Metabolism and interaction of bisphenol A in human hepatic cytochrome P450 and steroidogenic CYP17. Biol Pharm Bull 2001, 24:1064-1067. (Pubitemid 32894130)
51. Niwa T, Maekawa Y, Fujimoto M, Kishimoto K, Yabusaki Y, Ishibashi F, Katagiri M: Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol. Biol Pharm Bull 2002, 25:235-238. (Pubitemid 39592112)