Hepatoprotective effects of arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage

American Journal of Chinese Medicine

Volumn 28, Issue 2, 2000, Pages 163-173

  Lin, Song Chow ^a   Chung, Tsao Chuen ^a   Lin, Chun Ching ^b   Ueng, Tzuu Huei ^c   Lin, Yun Ho ^b   Lin, Shuw Yuan ^a   Wang, Li Ya ^d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d Department of Food and Nutrition   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CARBON TETRACHLORIDE; HERBACEOUS AGENT; PARACETAMOL; PLANT EXTRACT; POISON;

ANIMAL; ARTICLE; ASTERACEAE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; LIVER DISEASE; MALE; METABOLISM; MOUSE; PLANT ROOT;

ACETAMINOPHEN; ANIMALS; ANTIOXIDANTS; ASTERACEAE; CARBON TETRACHLORIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; LIVER; LIVER DISEASES; MALE; MICE; MICE, INBRED ICR; PLANT EXTRACTS; PLANT ROOTS; POISONS;

EID: 0033647831     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X00000210     Document Type: Article

References (40)

1. Albano, E., M. Rundgren, P.J. Harvison, S.D. Nelson and P. Moldeus. Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity. Mol. Pharmacol. 28: 306-311, 1985.
2. Anonymous. In vitro screening of traditional medicines for anti-HIV activity: memorandum from a WHO meeting. Bull. W.H.O. 67(6): 613-618,1989.
3. Benedetti, A., A. Casini and M. Comporti. Fatty acid composition of the major lipid classes of very low density lipoproteins and of plasma in rats poisoned with carbon tetrachloride. Res. Com. in Chem. Pathol. Pharmacol. 8(3): 447-460, 1974.
4. Bergmeyer, H.U., P. Scheibe and A.W. Wahlefeld. Optimization of methods for aspartate aminotransferase and alanine aminotransferase. Clin. Chem. 24(1): 58-73, 1978.
5. Buege, J.A. and S.D. Aust. Microsomal lipid peroxidation. Methods Enzymol. 52: 302-310, 1978.
6. Clawson, G.A. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol. Immunopath. Res. 8(2): 104-112, 1989.
7. Comporti, M. Lipid peroxidation and cellular damage in toxic liver injury. Lab. Invest. 53(6): 599-623. 1985.
8. Corongiu, P.P., G. Poli, M.U. Dianzani, K.H. Cheeseman and T.F. Slater. Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo. Chem. Biol. Interact. 59(2): 147-155, 1986.
9. Dahlin, D.C., G.T. Miwa, A.Y. Lu, and S.D. Nelson. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Pro. Nail. Acad. Sei. USA. 81(5): 1327-1331, 1984.
10. Fischer, V., P.R. West, S.D. Nelson, P.J. Harvison and R.P. Mason. Formation of 4 aminophenoxyl free radical from the acetaminophen metabolite N-acetyl-p-benzoquinone imine. J. Biol. Chem. 260(21): 11446-11450, 1985.
11. Grases, F., G. Melero, A. Costa-Bauza, R. Prieto, J.G. March. Urolithiasis and phytotherapy. Internat. Uro. Nephro. 26(5): 507-511,1994.
12. Hinson, J.A., L.R. Pohl, T.J. Monks and J.R. Gillette. Acetaminophen-induced hepatotoxicity. LifeSci. 29(2): 107-116, 1981.
13. Hoffmann, K.J., A.J. Streeter, D.B. Axworthy and T.A. Baillie. Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Mol. Pharmacol. 27(5): 566-573, 1985.
14. Uvakami, S., J.B. Wu, Y. Ebizuka and U. Sankawa. Platelet activating factor (PAF) antagonists contained in Arcthtm lappa L.: lignans and sesquiterpenes. Chemical & Pharmaceutical Bulletin. 40(5): 1196-1198, 1992.
15. Jeffrey, A., M.D. Brent, H. Barry and M.D. Rumack. Role of free radicals in toxic hepatic injury. II. Arc free radicals the cause of toxin-induced liver injury? Clin. Toxicol. 31(1): 173-196,1993.
16. Kalo, Y. and T. Watanabe. Isolation and characterization of a xyloglucan from gobo (Arctium lappa L.). Biosci., Biotech. & Biochem. 57(9): 1591-1592, 1993.
17. Lin, C.C., J.M. Lin, J J. Yang, S.C. Chung and T. Ujiie. Anti-inflammatory and radical scavenge effects of Arctium Lappa. Am. J. Chin. Med 24(2): 127-137, 1996.
18. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
19. Mason, R.P. and V. Fischer. Free radicals of acetaminophen: their subsequent reactions and toxicological significance. Fed. Proceed. 45(10): 2493-2499, 1986.
20. Miller, M.G. and D.J. Jollow. Relationship between Sulfotransferase activity and susceptibility to acctaminophen-induced liver necrosis in the hamster. Drug Metab. Dispos. 15(2): 143-150, 1987.
21. Mitchell, J.R. Acetaminophen toxicity. N. Engl. J. Med. 319(24): 1601-1602, 1988.
22. Morita, J., K. Ebihara, S. Kiriyama. Dietary fiber and fat-derivatives prevent mineral oil toxicity in rats by the same mechanism. J. Nutri. 123(9): 1575-1585, 1993.
23. Nelson, S.D. Molecular mechanisms of hepatotoxicity caused by acetaminophen. Semin. Liver Dis. 10(4): 267-278, 1990.
24. Nose, M., T. Fujimoto, T. Takeda, S. Nishibe and Y. Ogihara. Structural transformation of lignan compounds in rat gastrointestinal tract. Plant. Med. 58(6): 520-523, 1992.
25. Omura, T. and R. Sato. The carbon monoxide-binding pigment of liver microsomes. 1. Evidence for its hemoprotein nature. J. Biol. Chem. 239(7): 2370-2385, 1964.
26. Pencil, S.D., W.J. Jr. Brattin, E.A. Jr. Glende and R.O. Recknagel. Carbon tetrachloride-dependent inhibition of lipid secretion by isolated hepatocytes. Characterization and requirement for bioactivation. Biochem. Pharmacol. 33(15): 2419-2423, 1984.
27. Phillips, A.H. and R.G. Langdon. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies. J. Biol. Chem. 237(8): 2652-2660, 1962.
28. Potter, D.W. and J.A. Hinson. Reactions of N-acetyl-para-benzoquinoneimine with reduced glutathionc, acetaminophen, and NADPH. Mol. Pharmacol. 30(1): 33-41, 1986.
29. Potter, D.W. and J.A. Hinson. Acctaminophen peroxidation reactions. Dmg Metab. Rev. 20(2-4): 341-358, 1989.
30. Prescott, L.F. Paracetamol overdosage: pharmacological considerations and clinical management. Dmgs. 25: 290-314, 1983.
31. Recknagel, R.O., E.A. Glende, J.A. Dolak and R.L. Waller. Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther. 43(1): 139-154, 1989.
32. Rumore, M.M. and R.G. Blaiklock. Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity. J. Pharm. Sei. 81(3): 203-207, 1992.
33. Slater, T.F. Free-radical mechanisms in tissue injury. Biochem. J. 222(1 ): 1-15, 1984.
34. Slater, T.F., K.H. Cheeseman and K.U. Ingold. Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury. Philosophical Transactions of the Royal Society of London-series B: Biol. Sei. 311(1152): 633-645, 1985.
35. Sun, W.J., Z.F. Sha and H. Gao. Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC. Yao Hsueh Hsueh Pao-Acta Pharmaceiilica Sinica. 27(7): 549-551,1992.
36. Tietze, F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 27(3): 502-522, 1969.
37. Umehara, K., M. Nakamura, T. Miyase, M. Kuroyanagi and A. Ueno. Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2). Client. Pharmac. Bull. 44(12): 2300-2304, 1996.
38. Wang, H.Y. and J.S. Yang. Studies on the chemical constituents of Arc/him lappa L. Yao Hsueh Hsueh Pao - Acta P/iarniaceitlica Sinica. 28(12): 911-917, 1993.
39. Zieve, L., W.R. Anderson, R. Dozeman, K. Draves and C. Lyftogt. Acetaminophen liver injury: Sequential changes in two biochemical indices of regeneration and their relationship to histologie alterations. J. Lab. Clin. Med. 105(5): 619-624, 1985a.
40. Zievc, L., R. Dozeman, D. LaFontaine and K. Draves. Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat. J. Lab. Clin. Med. 106(5): 583-588, 1985b.