Mean glucose during ICU admission is related to mortality by a U-shaped curve in surgical and medical patients: A retrospective cohort study

Critical Care

Volumn 14, Issue 6, 2010, Pages

  Siegelaar, Sarah E ^a   Hermanides, Jeroen ^a   Oudemans van Straaten, Heleen M ^b   van der Voort, Peter H J ^b   Bosman, Robert J ^b   Zandstra, Durk F ^b   DeVries, J Hans ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Onze Lieve Vrouwe Gasthuis ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ADULT; ARTICLE; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; SURGICAL PATIENT; TEACHING HOSPITAL; AGED; COHORT ANALYSIS; COMPARATIVE STUDY; CRITICAL ILLNESS; HOSPITALIZATION; INTENSIVE CARE; METABOLISM; MIDDLE AGED; RETROSPECTIVE STUDY;

ADULT; AGED; BLOOD GLUCOSE; COHORT STUDIES; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PATIENT ADMISSION; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 78651502340     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9369     Document Type: Article

References (35)

1. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet 2009, 373:1798-1807. 10.1016/S0140-6736(09)60553-5, 19465235.
2. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003, 78:1471-1478. 10.4065/78.12.1471, 14661676.
3. Dossett LA, Cao H, Mowery NT, Dortch MJ, Morris J, May AK. Blood glucose variability is associated with mortality in the surgical intensive care unit. Am Surg 2008, 74:679-685.
4. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006, 105:244-252. 10.1097/00000542-200608000-00006, 16871057.
5. Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critical ill patients. Crit Care Med 2008, 36:3008-3013. 10.1097/CCM.0b013e31818b38d2, 18824908.
6. Hermanides J, Vriesendorp TM, Bosman RJ, Zandstra DF, Hoekstra JB, DeVries JH. Glucose variability is associated with intensive care unit mortality. Crit Care Med 2010, 38:838-842. 10.1097/CCM.0b013e3181cc4be9, 20035218.
7. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345:1359-1367. 10.1056/NEJMoa011300, 11794168.
8. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R. Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354:449-461. 10.1056/NEJMoa052521, 16452557.
9. Van den Berghe G, Wilmer A, Milants I, Wouters PJ, Bouckaert B, Bruyninckx F, Bouillon R, Schetz M. Intensive insulin therapy in mixed medical/surgical intensive care units. Diabetes 2006, 55:3151-3159. 10.2337/db06-0855, 17065355.
10. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K, . German Competence Network Sepsis (SepNet) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008, 358:125-139. 10.1056/NEJMoa070716, 18184958, German Competence Network Sepsis (SepNet).
11. Devos P, Preiser JC, Melot C. Impact of tight glucose control by intensive insulin therapy on ICU mortality and the rate of hypoglycemia: final results of the Glucontrol study. Intensive Care Med 2007, 33(Suppl 2):S189.
12. Preiser JC, Devos P, Ruiz-Santana S, Mélot C, Annane D, Groeneveld J, Iapichino G, Leverve X, Nitenberg G, Singer P, Wernerman J, Joannidis M, Stecher A, Chioléro R. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med 2009, 35:1738-1748. 10.1007/s00134-009-1585-2, 19636533.
13. The NICE-SUGAR Study Investigators Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009, 360:1283-1297. 10.1056/NEJMoa0810625, 19318384, The NICE-SUGAR Study Investigators.
14. Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 2009, 180:821-827. 2665940, 19318387.
15. Rood E, Bosman RJ, van der Spoel JI, Taylor P, Zandstra DF. Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc 2005, 12:172-180. 10.1197/jamia.M1598, 551549, 15561795.
16. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
17. Hermanides J, Bosman RJ, Vriesendorp TM, Dotsch R, Rosendaal FR, Zandstra DF, Hoekstra JB, DeVries JH. Hypoglycaemia is related with intensive care unit mortality. Crit Care Med 2010, 38:1430-1434. 10.1097/CCM.0b013e3181de562c, 20386307.
18. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002, 87:978-982. 10.1210/jc.87.3.978, 11889147.
19. Krinsley JS. Glycemic control, diabetic status, and mortality in a heterogeneous population of critically ill patients before and during the era of intensive glycemic management: six and one-half years experience at a university-affiliated community hospital. Semin Thorac Cardiovasc Surg 2006, 18:317-325. 10.1053/j.semtcvs.2006.12.003, 17395028.
20. Kosiborod M, Inzucchi SE, Krumholz HM, Xiao L, Jones PG, Fiske S, Masoudi FA, Marso SP, Spertus JA. Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk. Circulation 2008, 117:1018-1027. 10.1161/CIRCULATIONAHA.107.740498, 18268145.
21. Pinto DS, Skolnick AH, Kirtane AJ, Murphy SA, Barron HV, Giugliano RP, Cannon CP, Braunwald E, Gibson CM. U-shaped relationship of blood glucose with adverse outcomes among patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2005, 46:178-180. 10.1016/j.jacc.2005.03.052, 15992655.
22. Pinto DS, Kirtane AJ, Pride YB, Murphy SA, Sabatine MS, Cannon CP, Gibson CM. Association of blood glucose with angiographic and clinical outcomes among patients with ST-segment elevation myocardial infarction (from the CLARITY-TIMI-28 study). Am J Cardiol 2008, 101:303-307. 10.1016/j.amjcard.2007.08.034, 18237589.
23. Currie CJ, Peters JR, Tynan A, Evans M, Heine RJ, Bracco OL, Zagar T, Poole CD. Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study. Lancet 2010, 375:481-489. 10.1016/S0140-6736(09)61969-3, 20110121.
24. Bagshaw SM, Egi M, George C, Bellomo R. Early blood glucose control and mortality in critically ill patients in Australia. Crit Care Med 2009, 37:463-470. 10.1097/CCM.0b013e318194b097, 19114915.
25. Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Hegarty C, Bailey M. Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med 2008, 36:2249-2255. 10.1097/CCM.0b013e318181039a, 18664780.
26. Falciglia M, Freyberg RW, Almenoff PL, D'Alessio DA, Render ML. Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med 2009, 37:3001-3009. 10.1097/CCM.0b013e3181b083f7, 2905804, 19661802.
27. Bagshaw SM, Bellomo R, Jacka M, Egi M, Hart G, George C, . the ANZICS CORE Management Committee The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care 2009, 13:R91. 10.1186/cc7921, 2717463, 19534781, the ANZICS CORE Management Committee.
28. Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: Risk factors and outcomes. Crit Care Med 2007, 35:2262-2267. 10.1097/01.CCM.0000282073.98414.4B, 17717490.
29. Vriesendorp TM, DeVries JH, van Santen S, Moeniralam HS, de Jonge E, Roos YB, Schultz MJ, Rosendaal FR, Hoekstra JB. Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med 2006, 34:2714-2718. 10.1097/01.CCM.0000241155.36689.91, 16943734.
30. Hoedemaekers CWE, Klein Gunnewiek JMT, Prinsen MA, Willems JL, Van der Hoeven JG. Accuracy of bedside glucose measurement from three glucometers in critically ill patients. Crit Care Med 2008, 36:3062-3066. 10.1097/CCM.0b013e318186ffe6, 18824915.
31. Karon BS, Gandhi GY, Nuttall GA, Bryant SC, Schaff HV, McMahon MM, Santrach PJ. Accuracy of roche accu-chek inform whole blood capillary, arterial, and venous glucose values in patients receiving intensive intravenous insulin therapy after cardiac surgery. Am J Clin Pathol 2007, 127:919-926. 10.1309/6RFQCKAAJGKWB8M4, 17509989.
32. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest 2010, 137:544-551. 10.1378/chest.09-1737, 20018803.
33. Meyfroidt G, Keenan DM, Wang X, Wouters PJ, Veldhuis JD, Van den Berghe G. Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality. Crit Care Med 2010, 38:1021-1029. 10.1097/CCM.0b013e3181cf710e, 20124887.
34. Van den Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D. Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target?. J Clin Endocrinol Metab 2009, 94:3163-3170. 10.1210/jc.2009-0663, 19531590.
35. Kramer AA, Zimmerman JE. Predicting outcomes for cardiac surgery patients after intensive care unit admission. Semin Cardiothorac Vasc Anesth 2008, 12:175-183. 10.1177/1089253208323413, 18805852.