Association of Blood Glucose With Angiographic and Clinical Outcomes Among Patients With ST-Segment Elevation Myocardial Infarction (from the CLARITY-TIMI-28 Study)

American Journal of Cardiology

Volumn 101, Issue 3, 2008, Pages 303-307

  Pinto, Duane S ^a   Kirtane, Ajay J ^a   Pride, Yuri B ^a   Murphy, Sabina A ^a   Sabatine, Marc S ^b   Cannon, Christopher P ^b   Gibson, C Michael ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; GLUCOSE;

ADULT; ANGIOGRAPHY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; HEART INFARCTION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; ST SEGMENT ELEVATION;

BLOOD GLUCOSE; CORONARY ANGIOGRAPHY; FEMALE; HOSPITAL MORTALITY; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLATELET AGGREGATION INHIBITORS; RETROSPECTIVE STUDIES; THROMBOLYTIC THERAPY; TICLOPIDINE; TREATMENT OUTCOME;

EID: 38549120907     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2007.08.034     Document Type: Article

References (30)

1. Mukamal K.J., Nesto R.W., Cohen M.C., Muller J.E., Maclure M., Sherwood J.B., and Mittleman M.A. Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction. Diabetes Care 24 (2001) 1422-1427
2. Haffner S.M., Lehto S., Ronnemaa T., Pyorala K., and Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339 (1998) 229-234
3. Stranders I., Diamant M., van Gelder R.E., Spruijt H.J., Twisk J.W., Heine R.J., and Visser F.C. Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus. Arch Intern Med 164 (2004) 982-988
4. Foo K., Cooper J., Deaner A., Knight C., Suliman A., Ranjadayalan K., and Timmis A.D. A single serum glucose measurement predicts adverse outcomes across the whole range of acute coronary syndromes. Heart 89 (2003) 512-516
5. Hadjadj S., Coisne D., Mauco G., Ragot S., Duengler F., Sosner P., Torremocha F., Herpin D., and Marechaud R. Prognostic value of admission plasma glucose and HbA in acute myocardial infarction. Diabet Med 21 (2004) 305-310
6. Wahab N.N., Cowden E.A., Pearce N.J., Gardner M.J., Merry H., and Cox J.L. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?. J Am Coll Cardiol 40 (2002) 1748-1754
7. Bhadriraju S., Ray K.K., DeFranco A.C., Barber K., Bhadriraju P., Murphy S.A., Morrow D.A., McCabe C.H., Gibson C.M., Cannon C.P., and Braunwald E. Association between blood glucose and long-term mortality in patients with acute coronary syndromes in the OPUS-TIMI 16 trial. Am J Cardiol 97 (2006) 1573-1577
8. Worthley M.I., Holmes A.S., Willoughby S.R., Kucia A.M., Heresztyn T., Stewart S., Chirkov Y.Y., Zeitz C.J., and Horowitz J.D. The deleterious effects of hyperglycemia on platelet function in diabetic patients with acute coronary syndromes mediation by superoxide production, resolution with intensive insulin administration. J Am Coll Cardiol 49 (2007) 304-310
9. Ferroni P., Basili S., Falco A., and Davi G. Platelet activation in type 2 diabetes mellitus. J Thromb Haemost 2 (2004) 1282-1291
10. Watala C., Golanski J., Pluta J., Boncler M., Rozalski M., Luzak B., Kropiwnicka A., and Drzewoski J. Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic control. Thromb Res 113 (2004) 101-113
11. Pinto D.S., Skolnick A.H., Kirtane A.J., Murphy S.A., Barron H.V., Giugliano R.P., Cannon C.P., and Gibson C.M. U-shaped relationship of blood glucose with adverse outcomes among patients with ST-elevation myocardial infarction. J Am Coll Cardiol 46 (2005) 178-183
12. Timmer J.R., Ottervanger J.P., de Boer M.-J., Dambrink J.-H.E., Hoorntje J.C.A., Gosselink A.T.M., Suryapranata H., Zijlstra F., and van't Hof A.W.J. Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction. J Am Coll Cardiol 45 (2005) 999-1002
13. Prasad A., Stone G.W., Stuckey T.D., Costantini C.O., Zimetbaum P.J., McLaughlin M., Mehran R., Garcia E., Tcheng J.E., and Cox D.A. Impact of diabetes mellitus on myocardial perfusion after primary angioplasty in patients with acute myocardial infarction. J Am Coll Cardiol 45 (2005) 508-514
14. Sabatine M.S., Cannon C.P., Gibson C.M., Lopez-Sendon J.L., Montalescot G., Theroux P., Claeys M.J., Cools F., Hill K.A., Skene A.M., McCabe C.H., Braunwald E., and CLARITY-TIMI 28 Investigators. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 352 (2005) 1179-1189
15. TIMI Study Group. The Thrombolysis In Myocardial Infarction (TIMI) trial. Phase I findings. N Engl J Med 312 (1985) 932-936
16. Sabatine M.S., McCabe C.H., Gibson C.M., and Cannon C.P. Design and rationale of Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis In Myocardial Infarction (CLARITY-TIMI) 28 trial. Am Heart J 149 (2005) 227-233
17. Morrow D.A., Antman E.M., Charlesworth A., Cairns R., Murphy S.A., de Lemos J.A., Giugliano R.P., McCabe C.H., and Braunwald E. TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: an intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation 102 (2000) 2031-2037
18. Morrow D.A., Antman E.M., Giugliano R.P., Cairns R., Charlesworth A., Murphy S.A., de Lemos J.A., McCabe C.H., and Braunwald E. A simple risk index for rapid initial triage of patients with ST-elevation myocardial infarction: an InTIME II substudy. Lancet 358 (2001) 1571-1575
19. Norhammar A., Tenerz A., Nilsson G., Hamsten A., Efendic S., Ryden L., and Malmberg K. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet 359 (2002) 2140-2144
20. Cleveland W.S., and Devlin S.J. Locally weighted regression: an approach to regression analysis by local fitting. J Am Stat Assoc 83 (1988) 596-610
21. Gresele P., Guglielmini G., De Angelis M., Ciferri S., Ciofetta M., Falcinelli E., Lalli C., Ciabattoni G., Davi G., and Bolli G.B. Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type II diabetes mellitus. J Am Coll Cardiol 41 (2003) 1013-1020
22. Sakamoto T., Ogawa H., Kawano H., Hirai N., Miyamoto S., Takazoe K., Soejima H., Kugiyama K., Yoshimura M., and Yasue H. Rapid change of platelet aggregability in acute hyperglycemia. Detection by a novel laser-light scattering method. Thromb Haemost 83 (2000) 475-479
23. Angiolillo D.J., Bernardo E., Ramirez C., Costa M.A., Sabate M., Jimenez-Quevedo P., Hernandez R., Moreno R., Escaned J., Alfonso F., et al. Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J Am Coll Cardiol 48 (2006) 298-304
24. Alberti K.G., and Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15 (1998) 539-553
25. Tenerz A., Lonnberg I., Berne C., Nilsson G., and Leppert J. Myocardial infarction and prevalence of diabetes mellitus. Is increased casual blood glucose at admission a reliable criterion for the diagnosis of diabetes?. Eur Heart J 22 (2001) 1102-1110
26. Aguilar D., Solomon S.D., Kober L., Rouleau J.L., Skali H., McMurray J.J., Francis G.S., Henis M., O'Connor C.M., Diaz R., et al. Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. Circulation 110 (2004) 1572-1578
27. Malmberg K., Ryden L., Efendic S., Herlitz J., Nicol P., Waldenstrom A., Wedel H., and Welin L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 26 (1995) 57-65
28. Van den Berghe G., Wilmer A., Hermans G., Meersseman W., Wouters P.J., Milants I., Van Wijngaerden E., Bobbaers H., and Bouillon R. Intensive insulin therapy in the medical ICU. N Engl J Med 354 (2006) 449-461
29. Malmberg K., Ryden L., Wedel H., Birkeland K., Bootsma A., Dickstein K., Efendic S., Fisher M., Hamsten A., Herlitz J., et al., DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 26 (2005) 650-661
30. Ishihara M., Kagawa E., Inoue I., Kawagoe T., Shimatani Y., Kurisu S., Nakama Y., Maruhashi T., Ookawa K., Dai K., and Aokage Y. Impact of admission hyperglycemia and diabetes mellitus on short- and long-term mortality after acute myocardial infarction in the coronary intervention era. Am J Cardiol 99 (2007) 1674-1679