Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia

Respiratory Research

Volumn 12, Issue 1, 2011, Pages

  Mendez, Michael P ^a   Monroy, Yeni K ^b   Du, Ming ^b   Preston, Angela M ^b   Tolle, Leslie ^b   Lin, Yujing ^b   VanDussen, Kelli L ^d   Samuelson, Linda C ^d   Standiford, Theodore J ^c   Curtis, Jeffery L ^b,c   Beck, James M ^b,c   Christensen, Paul J ^b,c   Paine, Robert ^e,f  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b Veteran Affairs Health System   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f Veterans Affairs Health System   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; SOLUBLE INTERCELLULAR ADHESION MOLECULE 1; SURFACTANT PROTEIN C; UNCLASSIFIED DRUG; 2 (2,6 DICHLORO 4 ((3 FURAN 2 YLACRYLOYLAMINO)METHYL)BENZOYLAMINO) 3 ((THIAZOLIDINE 4 CARBONYL)AMINO)PROPIONIC ACID; 2-(2,6-DICHLORO-4-((3-FURAN-2-YLACRYLOYLAMINO)METHYL)BENZOYLAMINO)-3-((THIAZOLIDINE-4-CARBONYL)AMINO)PROPIONIC ACID; ACRYLAMIDE DERIVATIVE; AUTACOID; BETA ALANINE; CXCL2 CHEMOKINE; CXCL2 PROTEIN, MOUSE; DRUG DERIVATIVE; SFTPC PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL PNEUMONIA; BINDING AFFINITY; CELL FUNCTION; CHEMOLUMINESCENCE; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPHENOTYPING; INNATE IMMUNITY; KLEBSIELLA PNEUMONIAE; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; MOLECULAR WEIGHT; MORTALITY; MOUSE; NONHUMAN; PHAGOCYTOSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROMOTER REGION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMOTAXIS; DISEASE MODEL; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; KLEBSIELLA INFECTION; LUNG ALVEOLUS; METABOLISM; MICROBIOLOGY; PATHOGENICITY; TIME; TRANSGENIC MOUSE; UPREGULATION;

ACRYLAMIDES; ANIMALS; BETA-ALANINE; CELLS, CULTURED; CHEMOKINE CXCL2; CHEMOTAXIS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHAGOCYTOSIS; PNEUMONIA, BACTERIAL; PROMOTER REGIONS, GENETIC; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 78651500172     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-12     Document Type: Article

References (29)

1. Stolpe Avd, Saag PTvd: Intercellular adhesion molecule-1. J Mol Med 1996, 74: 13-33.
2. Paine R, Morris SB, Jin H, Baleeiro CE, Wilcoxen SE: ICAM-1 facilitates alveolar macrophage phagocytic activity through effects on migration over the AEC surface. Am J Physiol Lung Cell Mol Physiol 2002, 283 (1) : L180-187.
3. Basit A, Reutershan J, Morris MA, Solga M, Rose CE Jr, Ley K: ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Am J Physiol Lung Cell Mol Physiol 2006, 291 (2) : L200-207.
4. Qin L, Quinlan WM, Doyle NA, Graham L, Sligh JE, Takei F, Beaudet AL, Doerschuk CM: The roles of CD11/CD18 and ICAM-1 in acute Pseudomonas aeruginosa-induced pneumonia in mice. J Immunol 1996, 157 (11) : 5016-5021.
5. Mulligan MS, Vaporciyan AA, Warner RL, Jones ML, Foreman KE, Miyasaka M, Todd RF, Ward PA: Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury. J Immunol 1995, 154 (3) : 1350-1363.
6. Conner ER, Ware LB, Modin G, Matthay M: Elevated Pulmonary Edema Fluid Concentrations of Soluble Intercellular Adhesion Molcule-1 in Patients With Acute Lung Injury. Chest 1999, 116: 83S-85S.
7. Mendez MP, Morris SB, Wilcoxen S, Greeson E, Moore B, Paine R: Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2006, 290 (5) : L962-970.
8. Labarrere CA, Nelson DR, Miller SJ, Nieto JM, Conner JA, Pitts DE, Kirlin PC, Halbrook HG: Value of serum-soluble intercellular adhesion molecule-1 for the noninvasive risk assessment of transplant coronary artery disease, posttransplant ischemic events, and cardiac graft failure. Circulation 2000, 102 (13) : 1549-1555.
9. Mendez MP, Morris SB, Wilcoxen S, Du M, Monroy YK, Remmer H, Murphy H, Christensen PJ, Paine R: Disparate mechanisms of sICAM-1 production in the peripheral lung: contrast between alveolar epithelial cells and pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 2008, 294 (4) : L807-814.
10. Ishii Y, Kitamura S: Soluble intercellular adhesion molecule-1 as an early detection marker for radiation pneumonitis. Eur Respir J 1999, 13 (4) : 733-738.
11. Grigg J, Riedler J, Robertson CF: Bronchoalveolar lavage fluid cellularity and soluble intercellular adhesion molecule-1 in children with colds. Pediatr Pulmonol 1999, 28 (2) : 109-116.
12. Grigg J, Riedler J, Robertson CF: Soluble intercellular adhesion molecule-1 in the bronchoalveolar lavage fluid of normal children exposed to parental cigarette smoke. Eur Respir J 1999, 13 (4) : 810-813.
13. Kim DS, Paik SH, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD: Value of ICAM-1 expression and soluble ICAM-1 level as a marker of activity in sarcoidosis. Chest 1999, 115 (4) : 1059-1065.
14. Tsakadze NL, Sithu SD, Sen U, English WR, Murphy G, D'Souza SE: Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). J Biol Chem 2006, 281 (6) : 3157-3164.
15. Schmal H, Czermak BJ, Lentsch AB, Bless NM, Beck-Schimmer B, Friedl HP, Ward PA: Soluble ICAM-1 Activates Lung Macrophages and Enhances Lung Injury. Journal of Immunolgy 1998, 161: 3685-3693.
16. Wang HW, Babic AM, Mitchell HA, Liu K, Wagner DD: Elevated soluble ICAM-1 levels induce immune deficiency and increase adiposity in mice. FASEB J 2005, 19 (8) : 1018-1020.
17. Nagy ZP, Dozortsev D, Diamond M, Rienzi L, Ubaldi F, Abdelmassih R, Greco E: Pronuclear morphology evaluation with subsequent evaluation of embryo morphology significantly increases implantation rates. Fertil Steril 2003, 80 (1) : 67-74.
18. Baleeiro CE, Wilcoxen SE, Morris SB, Standiford TJ, Paine R: Sublethal hyperoxia impairs pulmonary innate immunity. J Immunol 2003, 171 (2) : 955-963.
19. Paine R, Morris SB, Jin H, Wilcoxen SE, Phare SM, Moore BB, Coffey MJ, Toews GB: Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice. Am J Physiol Lung Cell Mol Physiol 2001, 281 (5) : L1210-1218.
20. O'brien AD, Standiford TJ, Bucknell KA, Wilcoxen SE, P R III: Role of alveolar epithelial cell intercellular adhesion molecule-1 in host defense against Klebsiella pneumoniae. Lung Cell Mol Physiol 1999, 20: L961-L970.
21. Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA: Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Clin Invest 1996, 97 (3) : 649-655.
22. Dhami R, Zay K, Gilks B, Porter S, Wright JL, Churg A: Pulmonary epithelial expression of human alpha1-antitrypsin in transgenic mice results in delivery of alpha1-antitrypsin protein to the interstitium. J Mol Med 1999, 77 (4) : 377-385.
23. Witkowska AM, Borawska MH: Soluble intercellular adhesion molecule-1 (sICAM-1): an overview. Eur Cytokine Netw 2004, 15 (2) : 91-98.
24. Otto VI, Schurpf T, Folkers G, Cummings RD: Sialylated complex-type N-glycans enhance the signaling activity of soluble intercellular adhesion molecule-1 in mouse astrocytes. J Biol Chem 2004, 279 (34) : 35201-35209.
25. Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA: CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol 2002, 27 (4) : 474-480.
26. Humlicek AL, Pang L, Look DC: Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1. Am J Physiol Lung Cell Mol Physiol 2004, 287 (3) : L598-607.
27. Choi S, Lee H, Choi JR, Oh ES: Shedding; towards a new paradigm of syndecan function in cancer. BMB Rep 2010, 43 (5) : 305-310.
28. Buckley ST, Ehrhardt C: The receptor for advanced glycation end products (RAGE) and the lung. J Biomed Biotechnol 2010, 2010: 917108.
29. van Den Engel NK, Heidenthal E, Vinke A, Kolb H, Martin S: Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1. Blood 2000, 95 (4) : 1350-1355.