Comparison of viable cell concentration estimation methods for a mammalian cell cultivation process

Cytotechnology

Volumn 62, Issue 5, 2010, Pages 413-422

  Aehle, M ^a   Simutis, R ^b   Lubbert A ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b KAUNAS UNIVERSITY OF TECHNOLOGY   (Lithuania)

Author keywords

Artificial neural networks; Biomass estimation; Mammalian cell culture; Multivariate regression; Support vector regression

Indexed keywords

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL GROWTH; CELL VIABILITY; CHO CELL; CONCENTRATION (PARAMETERS); FED BATCH CULTURE; HYBRID; INTERMETHOD COMPARISON; LINEAR REGRESSION ANALYSIS; MAMMAL CELL; NONHUMAN; NONLINEAR REGRESSION ANALYSIS; VALIDATION PROCESS;

MAMMALIA;

EID: 78651489829     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-010-9291-z     Document Type: Article

References (28)

1. U Behrendt S Koch DD Gooch U Steegmans MJ Comer 1994 Mass spectrometry: a tool for on-line monitoring of animal cell cultures Cytotechnol 14 157 162 1:STN:280:DyaK2M%2FnvVSlsA%3D%3D 10.1007/BF00749612
2. TA Bibila DK Robinson 1995 In pursuit of the optimal fed-batch process for monoclonal antibody production Biotechnol Progr 11 1 13 1:CAS:528: DyaK2MXjsVSls7g%3D 10.1021/bp00031a001
3. M Brinkmann D Lütkemeyer F Gudermann J Lehmann 2002 New technologies for automated cell counting based on optical image analysis 'The Cellscreen' Cytotechnology 38 119 127 1:CAS:528:DC%2BD38XoslWqtLo%3D 10.1023/A:1021118501866
4. C Cannizzaro R Gügerli I Marison Uv Stockar 2003 On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy Biotechnol Bioeng 84 5 597 610 1:CAS:528:DC%2BD3sXovFWmsrg%3D 10.1002/bit.10809
5. Chang C-C, Lin CJ (2001) LIBSVM: a library for support vector machines, Software available at http://www.csie.ntu.edu.tw/~cjlin/libsvm
6. L Chu DK Robinson 2001 Industrial choice for protein production by large-scale cell culture Curr Op Biotechnol 12 180 187 1:CAS:528: DC%2BD3MXjt1Olu7Y%3D 10.1016/S0958-1669(00)00197-X
7. RC Dorresteijn K Harbrink Numan CD de Gooijer J Tramper EC Beuvery 1996 On-line estimation of the biomass activity during animal-cell cultivations Biotechnol Bioeng 51 2 206 214 1:CAS:528:DyaK28XjslOku7g%3D 10.1002/(SICI)1097- 0290(19960720)51:2<206::AID-BIT10>3.0.CO;2-K
8. H Drucker CJC Burges L Kaufman A Smola V Vapnik 1997 Support vector regression machines Adv Neural Inf Process Syst 9 155 161
9. P Ducommun I Bolzonella M Rhiel P Pugeaud Stockar Uv IW Marison 2001 On-line determination of animal cell concentration Biotechnol Bioeng 72 5 515 522 1:CAS:528:DC%2BD3MXhs1Omt7o%3D 10.1002/1097-0290(20010305)72:5<515::AID- BIT1015>3.0.CO;2-Q
10. K Eyer E Heinzle 1996 On-line estimation of viable cells in a hybridoma culture at various DO levels using ATP balancing and redox potential measurement Biotechnol Bioeng 49 3 277 283 1:CAS:528:DyaK28Xnt1Crsw%3D%3D 10.1002/(SICI)1097-0290(19960205)49:3<277::AID-BIT5>3.0.CO;2-H
11. FDA (2004) Guidance for industry: PAT-a framework for innovative pharmaceutical manufacturing and quality assurance, http://www.fda.gov/cvm/ guidance/published.html
12. JC Gunther JS Conner SE Seborg 2008 PLS pattern matching in design of experiment, batch process data Chemomet Intell Lab Syst 94 1 43 50 1:CAS:528:DC%2BD1cXhtVKltL%2FO 10.1016/j.chemolab.2008.06.011
13. K Hornik M Stinchcombe H White 1989 Multilayer feed-forward networks are universal approximators Neural Netw 2 359 366 10.1016/0893-6080(89)90020-8
14. P Hossler SF Khattak ZJ Li 2009 Optimal and consistent protein glycosylation in mammalian cell culture Glycobiology 19 9 936 949 1:CAS:528:DC%2BD1MXpslegs7s%3D 10.1093/glycob/cwp079
15. M Jenzsch R Simutis G Eisbrenner I Stückrath A Lübbert 2006 Estimation of biomass concentrations in fermentation processes for recombinant protein production Bioproc Biosyst Eng 29 1 19 27 1:CAS:528:DC%2BD28XltFWlu7g%3D 10.1007/s00449-006-0051-6
16. K Joeris J-G Frerichs K Konstantinov T Scheper 2002 In-situ microscopy: on-line process monitoring of mammalian cell cultures Cytotechnology 38 129 134 1:CAS:528:DC%2BD38XoslWqtLs%3D 10.1023/A:1021170502775
17. BH Junker HY Wang 2006 Bioprocess monitoring and computer control: key roots of the current PAT initiative Biotechnol Bioeng 95 2 226 261 1:CAS:528:DC%2BD28XhtVSjsr%2FP 10.1002/bit.21087
18. KB Konstantinov R Pambayun R Matanguihan T Yoshida CM Perusich W-S Hu 1992 On-line monitoring of hybridoma cell growth using a laser turbidity sensor Biotechnol Bioeng 40 1337 1342 1:CAS:528:DyaK3sXitV2rsg%3D%3D 10.1002/bit.260401107
19. R Luedeking EL Piret 1959 A kinetic study of lactic acid fermentation. Batch Process at controlled pH J Biochem Microb Technol 1 4 393 412 1:CAS:528:DyaF2cXmsVehsA%3D%3D 10.1002/jbmte.390010406
20. A Oeggerli K Eyer E Heinzle 1994 On-line gas analysis in animal cell cultivation: I. Control of dissolved oxygen and pH Biotechnol Bioeng 45 42 53 10.1002/bit.260450107
21. J Schubert R Simutis M Dors I Havlik A Lübbert 1994 Bioprocess optimization and control: application of hybrid modeling J Biotechnol 35 51 68 1:CAS:528:DyaK2cXltVKmt7Y%3D 10.1016/0168-1656(94)90189-9
22. K Schügerl 2001 Progress in monitoring, modeling and control of bioprocesses during the last 20 years J Biotechnol 85 2 149 173 10.1016/S0168-1656(00)00361-8
23. D Shah M Naciri P Clee M Al-Rubeai 2006 NucleoCounter-an efficient technique for the determination of cell number and viability in animal cell culture processes Cytotechnology 51 39 44 10.1007/s10616-006-9012-9
24. R Simutis R Oliveira M Manikowski S Feyo de Azevedo A Lübbert 1997 How to increase the performance of models for process optimization and control J Biotechnol 59 73 89 1:CAS:528:DyaK1cXhsFeisg%3D%3D 10.1016/S0168-1656(97)00166- 1
25. AP Teixeira CAM Portugal N Carinhas JML Dias JP Crespo PM Alves MJT Carrondo R Oliveira 2009 In situ 2D fluorometry and chemometric monitoring of mammalian cell cultures Biotechnol Bioeng 102 4 1098 1106 1:CAS:528: DC%2BD1MXhvFGhsrg%3D 10.1002/bit.22125
26. G Walsh 2006 Biopharmaceutical benchmarks Nat Biotechnol 24 7 769 776 1:CAS:528:DC%2BD28XmvFaguro%3D 10.1038/nbt0706-769
27. KF Wlaschin W-S Hu 2006 Fed-batch culture and dynamic nutrient feeding Adv Biochem Eng/Biotechnol 101 43 74 1:CAS:528:DC%2BD28Xht1WrtLfL 10.1007/10-015
28. DW Zabriskie AE Humphrey 1978 Real-time estimation of aerobic batch fermentation biomass concentration by component balancing AIChE J 24 138 146 1:CAS:528:DyaE1cXoslKhsQ%3D%3D 10.1002/aic.690240116