On-line estimation of the biomass activity during animal-cell cultivations

Biotechnology and Bioengineering

Volumn 51, Issue 2, 1996, Pages 206-214

  Dorresteijn, R C ^a   Harbrink Numan, K ^a   De Gooijer, C D ^a   Tramper, J ^a   Beuvery, E C ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

animal cells; biomass activity; oxygen solubility; software sensor

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINES; ANIMAL CELL CULTURE; BATCH CELL CULTURE; COMPUTER SOFTWARE; CONTINUOUS CELL CULTURE; ESTIMATION; ONLINE SYSTEMS; ORGANIC ACIDS; OXYGEN; SENSORS;

BIOMASS ACTIVITY; GLUTAMINE; HYBRIDOMA CELLS; ONLINE ESTIMATION; SOFTWARE SENSOR; VERO CELLS; VOLUMETRIC MASS ACTIVITY;

BIOMASS;

LACTIC ACID;

ANIMAL CELL; ARTICLE; BIOMASS; BIOREACTOR; COMPUTER PROGRAM; CONTROLLED STUDY; HYBRIDOMA; NONHUMAN; OXYGEN CONSUMPTION; PREDICTION; SENSOR; VERO CELL;

EID: 15844425965     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19960720)51:2<206::AID-BIT10>3.0.CO;2-K     Document Type: Article

References (36)

1. Barngrover, D., Thomas, J., Thilly, W. G. 1985. High density mammalian cell growth in leibovitz bicarbonate-free medium: effects of fructose and galactose on culture biochemistry. J. Cell Sci. 78: 173-189.
2. Bastin, G., Dochain, D. 1986. On-line estimation of microbial specific growth rates. Automatica 22: 705-709.
3. Dorresteijn, R. C., Berwald, L. G., Zomer, G., De Gooijer, C. D., Wieten, G., Beuvery, E. C. 1996. Determination of amino acids using o-phthaladehyde-2-mercaptoethanol derivatization: effect of reaction conditions. J. Chromatogr. 724: 159-167.
4. Dorresteijn, R. C., De Gooijer, C. D., Tramper, J., Beuvery, E. C. 1994. A method for simultaneous determination of solubility and transfer coefficient of oxygen in aqueous media using off-gas mass spectrometry. Biotechnol. Bioeng. 43: 149-154.
5. La during cultivation of animal cells. Biotechnol. Techniq. 8: 675-680.
6. Fleischaker, R. J., Sinskey, A. J. 1981. Oxygen demand and supply in cell culture. Eur. J. Appl. Microbiol. Biotechnol. 12: 193-197.
7. La with randomly pulsed dynamic method. Biotechnol. Bioeng. 37: 889-893
8. Glacken, M. W., Fleischaker, R. J., Sinskey, A. J. 1986. Reduction of waste product excretion via nutrient control: possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol. Bioeng. 28: 1376-1389.
9. Kilburn, D. G., Fitzpatrick, P., Blake-Coleman, B. C., Clarke, D. J., Griffiths, J. B. 1989. On-line monitoring of cell mass in mammalian cell cultures by acoustic densitometry. Biotechnol. Bioeng. 33: 1379-1384.
10. La with oxygen-enriched air during fermentation. J. Chem. Tech. Biotechnol. 45: 39-44.
11. Locher, G., Sonnleitner, B., Fiechter, A. 1992. On-line measurement in biotechnology: techniques. J. Biotechnol. 25: 23-53.
12. McLimans, W. F., Blumenson, L. E., Tunnah, K. V. 1968. Kinetics of gas diffusion in mammalian cell culture systems. II. Theory. Biotechnol. Bioeng. 10: 741-763.
13. Mignone, C. F., Ertola, R. J. 1984. Measurement of oxygen transfer coefficient under growth conditions by dynamic model moment analysis. J. Chem. Tech. Biotechnol. 34B: 121-126.
14. Miller, W. M., Wilke, C. R., Blanch, H. W. 1987. Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J. Cell. Physiol. 132: 524-530.
15. Montague, G. A., Morris, A. J., Tham, M. T. 1992. Enhancing bioprocess operability with generic software sensors. J. Biotechnol. 25: 183-201.
16. Mukhopadhyay, S. N., Ghose, T. K. 1976. A simple dynamic method for Kla determination in a laboratory fermenter. J. Ferment. Technol. 54: 406-419.
17. Nam, S. W., Kim, J. H. 1994. Indirect estimation of cell mass and substrate concentration using a computer-coupled mass spectrometer. J. Ferment. Bioeng. 77: 332-334.
18. Oishi, K., Tominaga M., Kawato, A., Abe, Y., Imayasu, S., Nanba, A. 1992. Development of on-line sensoring and computer aided control systems for sake brewing. J. Biotechnol. 24: 53-74.
19. 1 events and regulation of cell proliferation. Science 246: 603-609.
20. Quicker, G., Schumpe, A., König, B., Deckwer, W.-D. 1981. Comparison of measured and calculated oxygen solubilities in fermentation media. Biotechnol. Bioeng. 23: 635-650.
21. Reitzer, L. J., Burton, M. W., Kennel, D. 1979. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254: 2669-2676.
22. 2 solubility in aqueous media determined by a kinetic method. Anal. Biochem. 145: 406-418.
23. Royce, P. N. 1992. Effect of changes in the pH and carbon dioxide evolution rate on the measured respiratory quotient of fermentations. Biotechnol. Bioeng. 40: 1129-1138.
24. Schneider, H., Moser, A. 1984. On the methodology of dissolved oxygen saturation concentration measurement. Biotechnol. Lett. 6: 295-300.
25. + fluxes. Circ. Res. 74: 829-838.
26. Shimizu, H., Takamatsu, T. 1989. An algorithmic approach to constructing the on-line estimation system for the specific growth rate. Biotechnol. Bioeng. 33: 354-364.
27. Siegmund, D., Diekmann, H. 1989. Estimation of fermentation biomass concentration by measuring oxygen uptake off-line with an oxygen electrode. Appl. Microbiol. Biotechnol. 32: 32-36.
28. Simchowitz, L., Vogt, S. K. 1993. Substrate and inhibitor specificity of the lactate carrier of human neutrophils. J. Membr. Biol. 131: 23-34.
29. Slininger, O. J., Petroski, R. J., Bothast, R. J., Ladisch, M. R., Okos, M. R. 1989. Measurement of oxygen solubility in fermentation media: a colorimetric method. Biotechnol. Bioeng. 33: 578-583.
30. Sonnleitner B., Locher, G., Fiechter, A. 1992. Biomass determination. J. Biotechnol. 25: 5-22.
31. Stephanopoulos, G., San, K.-Y. 1982. On-line estimation of time-varying parameters. Application to biochemical reactors, pp. 195-199. In: IFAC Symposium on Modeling and Control of Biotechnical Processes, Helsinki, Finland.
32. Swiniarski R., Lesniewski, A., Dewshi, M. A. M., Ng, M. H., Leigh, J. R. 1982. Progress towards estimation of biomass in a batch fermentation process, pp. 231-242. In: IFAC Symposium on Modeling and Control of Biotechnical Processes, Helsinki, Finland.
33. Yamada, K., Furushou, S., Sugahara, T., Shirahata, S., Murakami, 1990. Relationship between oxygen consumption rate and cellular activity of mammalian cells cultured in serum-free medium. Biotechnol. Bioeng. 36: 759-762.
34. Yamane, T., Hibino, W., Ishihara, K., Kadotani, Y., Kominami, M. 1992. Fed-batch culture automated by uses of continuously measured cell concentration and culture volume. Biotechnol. Bioeng. 39: 550-555.
35. Yang, X. M., Mao, Z. X., Yang, S. Z., Mao, W. Y. 1988. An improved method for determination of the volumetric oxygen transfer coefficient in fermentation processes. Biotechnol. Bioeng. 31: 1006-1009.
36. Zabriskie, D. W., Humphrey, A. E. 1978. Real-time estimation of aerobic batch fermentation biomass concentration by component balancing. AIChE J. 24: 138-146.