Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats

Critical Care

Volumn 14, Issue 6, 2010, Pages

  Landsberger, Martin ^a   Zhou, Juan ^b   Wilk, Sebastian ^a   Thaumüller, Corinna ^a   Pavlovic, Dragan ^a   Otto, Marion ^a   Whynot, Sara ^b   Hung, Orlando ^b   Murphy, Michael F ^b   Cerny, Vladimir ^b,c   Felix, Stephan B ^a   Lehmann, Christian ^a,b  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; TUMOR NECROSIS FACTOR ALPHA; BACTERIUM ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; ENDOTOXEMIA; INTESTINE BLOOD FLOW; INTRAVITAL MICROSCOPY; LEUKOCYTE; MALE; MICROCIRCULATION; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; IMMUNOLOGY; INTESTINE MUCOSA; LEWIS RAT; PATHOLOGY; VASCULARIZATION;

ANIMALS; ANTIBODIES, BACTERIAL; CELL ADHESION; ENDOTOXEMIA; INTESTINAL MUCOSA; LEUKOCYTES; MALE; MICROCIRCULATION; RATS; RATS, INBRED LEW; SCAVENGER RECEPTORS, CLASS E;

EID: 78651471823     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9367     Document Type: Article

References (27)

1. Engel C, Brunkhorst FM, Bone HG, Brunkhorst R, Gerlach H, Grond S, Gruendling M, Huhle G, Jaschinski U, John S, Mayer K, Oppert M, Olthoff D, Quintel M, Ragaller M, Rossaint R, Stuber F, Weiler N, Welte T, Bogatsch H, Hartog C, Loeffler M, Reinhart K. Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med 2007, 33:606-618. 10.1007/s00134-006-0517-7, 17323051.
2. Ince C. The microcirculation is the motor of sepsis. Crit Care 2005, 9(suppl 4):S13-S19. 10.1186/cc3753, 16168069.
3. Chen M, Masaki T, Sawamura T. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 2002, 95:89-100. 10.1016/S0163-7258(02)00236-X, 12163130.
4. Kakutani M, Masaki T, Sawamura T. A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc Natl Acad Sci USA 2000, 97:360-364. 10.1073/pnas.97.1.360, 26668, 10618423.
5. Oka K, Sawamura T, Kikuta K, Itokawa S, Kume N, Kita T, Masaki T. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci USA 1998, 95:9535-9540. 10.1073/pnas.95.16.9535, 21373, 9689115.
6. Shimaoka T, Kume N, Minami M, Hayashida K, Sawamura T, Kita T, Yonehara S. LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J Immunol 2001, 166:5108-5114.
7. Chen M, Kakutani M, Minami M, Kataoka H, Kume N, Narumiya S, Kita T, Masaki T, Sawamura T. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 2000, 20:1107-1115.
8. Kataoka H, Kume N, Miyamoto S, Minami M, Moriwaki H, Murase T, Sawamura T, Masaki T, Hashimoto N, Kita T. Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation 1999, 99:3110-3117.
9. Nagase M, Kaname S, Nagase T, Wang G, Ando K, Sawamura T, Fujita T. Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis. J Am Soc Nephrol 2000, 11:1826-1836.
10. Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura T. Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci USA 2003, 100:1274-1279. 10.1073/pnas.0337528100, 298763, 12538855.
11. Li D, Mehta JL. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation 2000, 101:2889-2895.
12. Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, Campagnola M, Rigoni A, Pastorino AM, Lo Cascio V, Sawamura T. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 2000, 275:12633-12638. 10.1074/jbc.275.17.12633, 10777555.
13. Cominacini L, Rigoni A, Pasini AF, Garbin U, Davoli A, Campagnola M, Pastorino AM, Lo Cascio V, Sawamura T. The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide. J Biol Chem 2001, 276:13750-13755.
14. Pavlovic D, Frieling H, Lauer KS, Bac VH, Richter J, Wendt M, Lehmann C, Usichenko T, Meissner K, Gruendling M. Thermostatic tissue platform for intravital microscopy: 'the hanging drop' model. J Microsc 2006, 224:203-210. 10.1111/j.1365-2818.2006.01665.x, 17204068.
15. Harlow E. Antibodies: A Laboratory Manual 1988, Cold Spring Harbor: Cold Spring Harbor Laboratory.
16. Landsberger M, Wolff B, Jantzen F, Rosenstengel C, Vogelgesang D, Staudt A, Dahm JB, Felix SB. Cerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells. Atherosclerosis 2007, 190:43-52. 10.1016/j.atherosclerosis.2006.02.009, 16529752.
17. Aoyama T, Fujiwara H, Masaki T, Sawamura T. Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells. J Mol Cell Cardiol 1999, 31:2101-2114. 10.1006/jmcc.1999.1041, 10640439.
18. Mehta JL, Li DY. Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells. Biochem Biophys Res Commun 1998, 248:511-514. 10.1006/bbrc.1998.9004, 9703956.
19. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993, 92:1866-1874. 10.1172/JCI116778, 288351, 7691889.
20. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J 1995, 9:899-909.
21. Kume N, Murase T, Moriwaki H, Aoyama T, Sawamura T, Masaki T, Kita T. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 1998, 83:322-327.
22. Lehmann C, Egerer K, Georgiew A, Weber M, Grune T, Kox WJ. Inhibition of tumor necrosis factor-alpha release in rat experimental endotoxemia by treatment with the 21-aminosteroid U-74389G. Crit Care Med 1999, 27:1164-1167. 10.1097/00003246-199906000-00044, 10397223.
23. Voraberger G, Schafer R, Stratowa C. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region: induction by cytokines and phorbol ester. J Immunol 1991, 147:2777-2786.
24. Iademarco MF, McQuillan JJ, Rosen GD, Dean DC. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J Biol Chem 1992, 267:16323-16329.
25. Farquhar I, Martin CM, Lam C, Potter R, Ellis CG, Sibbald WJ. Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res 1996, 61:190-196. 10.1006/jsre.1996.0103, 8769965.
26. Schaper J, Ahmed R, Schafer T, Elster A, Enigk F, Habazettl H, Mousa S, Schafer M, Welte M. Volume therapy with colloid solutions preserves intestinal microvascular perfusion in endotoxaemia. Resuscitation 2008, 76:120-128. 10.1016/j.resuscitation.2007.06.026, 17697734.
27. Lehmann C, Bac VH, Pavlovic D, Lustig M, Maier S, Feyerherd F, Usichenko TI, Meissner K, Haase H, Junger M, Wendt M, Heidecke CD, Grundling M. Metronidazole improves intestinal microcirculation in septic rats independently of bacterial burden. Clin Hemorheol Microcirc 2006, 34:427-438.