A new family of peptide-nucleic acid nanostructures with potent transfection activities

Journal of Peptide Science

Volumn 17, Issue 2, 2011, Pages 88-93

  Bechinger, Burkhard ^a   Vidovic, Verica ^a   Bertani, Philippe ^a   Kichler, Antoine ^b,c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b GÉNÉTHON   (France)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

Antimicrobial peptide; Cell penetrating peptide; DNA; Histidine rich peptide; Isothermal titration calorimetry; Membrane interaction; SiRNA; Solid state NMR

Indexed keywords

AMINO ACID; CELL PENETRATING PEPTIDE; HISTIDINE; NANOMATERIAL; NUCLEIC ACID; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; SMALL INTERFERING RNA;

AMINO ACID SEQUENCE; CELL MEMBRANE; COMPLEX FORMATION; EUKARYOTIC CELL; GENE SILENCING; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; ISOTHERMAL TITRATION CALORIMETRY; MACROMOLECULE; MEASUREMENT; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; REVIEW; SOLID STATE;

CALORIMETRY; MAGNETIC RESONANCE SPECTROSCOPY; NANOSTRUCTURES; PEPTIDE NUCLEIC ACIDS; TRANSFECTION;

EUKARYOTA;

EID: 78651436138     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1318     Document Type: Review

References (32)

1. Li W, Szoka FC, Jr. Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 2007; 24: 438-449.
2. Behr JP. Synthetic gene-transfer vectors. Acc. Chem. Res. 1993; 26: 274-278.
3. Mintzer MA, Simanek EE. Nonviral vectors for gene delivery. Chem. Rev. 2009; 109: 259-302.
4. Wagner E, Zenke M, Cotten M, Beug H, Birnstiel ML. Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 3410-3414.
5. Plank C, Oberhauser B, Mechtler K, Koch C, Wagner E. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 1994; 269: 12918-12924.
6. Wyman TB, Nicol F, Zelphati O, Scaria PV, Plank C, Szoka FC Jr. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry 1997; 36: 3008-3017.
7. Gottschalk S, Sparrow JT, Hauer J, Mims MP, Leland FE, Woo SL, Smith LC. A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cells. Gene Ther. 1996; 3: 448-457.
8. Niidome T, Takaji K, Urakawa M, Ohmori N, Wada A, Hirayama T, Aoyagi H. Chain length of cationic alpha-helical peptide sufficient for gene delivery into cells. Bioconjugate Chem. 1999; 10: 773-780.
9. Morris MC, Chaloin L, Mery J, Heitz F, Divita G. A novel potent strategy for gene delivery using a single peptide vector as a carrier. Nucleic Acids Res. 1999; 27: 3510-3517.
10. Rittner K, Benavente A, Bompard-Sorlet A, Heitz F, Divita G, Brasseur R, Jacobs E. New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo. Mol. Ther. 2002; 5: 104-114.
11. Kichler A, Pages JC, Leborgne C, Druillennec S, Lenoir Coulaud D, Delain E, Le Cam E, Roques BP, Danos O. Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R. J. Virol. 2000; 74: 5424-5431.
12. Kichler A, Leborgne C, MÑrz J, Danos O, Bechinger B. Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 2003; 100: 1564-1568.
13. Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman Demeneix B, Behr JP. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 1995; 92: 7297-7301.
14. Midoux P, Monsigny M. Efficient gene transfer by histidylated polylysine/pDNA complexes. Bioconjugate Chem. 1999; 10: 406-411.
15. Bechinger B. Towards membrane protein design: pH dependent topology of histidine-containing polypeptides. J. Mol. Biol. 1996; 263: 768-775.
16. Georgescu J, Bechinger B. NMR structures of the histidine-rich peptide LAH4 in micellar environments: membrane insertion, pH-dependent mode of antimicrobial action and DNA transfection. Biophys. J. 2010; In press.
17. Vogt TCB, Bechinger B. The interactions of histidine-containing amphipathic helical peptide antibiotics with lipid bilayers: the effects of charges and pH. J. Biol. Chem. 1999; 274: 29115-29121.
18. Mason AJ, Bechinger B, Kichler A. Rational design of vector and antibiotic peptides using solid-state NMR. Mini Rev. Med. Chem. 2007; 7: 491-497.
19. Mason AJ, Moussaoui W, Abdelrhaman T, Boukhari A, Bertani P, Marquette A, Shooshtarizaheh P, Moulay G, Boehm N, Guerold B, Sawers RJH, Kichler A, Metz-Boutigue MH, Candolfi E, Prevost G, Bechinger B. Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine rich amphipathic cationic peptides. J. Biol. Chem. 2009; 284: 119-133.
20. Mason AJ, Gasnier C, Kichler A, Prevost G, Aunis D, Metz-Boutigue MH, Bechinger B. Enhanced membrane disruption and antibiotic action against pathogenic bacteria by designed histidine-rich peptides at acidic pH. Antimicrob. Agents Chemother. 2006; 50: 3305-3311.
21. Langlet-Bertin B, Leborgne C, Scherman D, Bechinger B, Mason AJ, Kichler A. Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery. Pharm. Res. 2010; 27: 1426-1436.
22. Mason AJ, Martinez A, Glaubitz C, Danos O, Kichler A, Bechinger B. The antibiotic and DNA-transfecting peptide LAH4 selectively associates with, and disorders, anionic lipids in mixed membranes. FASEB J. 2006; 20: 320-322.
23. Kichler A, Mason AJ, Bechinger B. Cationic amphipathic histidine-rich peptides for gene delivery. Biochim. Biophys. Acta 2006; 1576: 301-307.
24. Mason AJ, Leborgne C, Moulay G, Martinez A, Danos O, Bechinger B, Kichler A. Optimising histidine rich peptides for efficient DNA delivery in the presence of serum. J. Controlled Release 2007; 118: 95-104.
25. Prongidi-Fix L, Sugewara M, Bertani P, Raya J, Leborgne C, Kichler A, Bechinger B. Self-promoted uptake of peptide/DNA transfection complexes. Biochemistry 2007; 46: 11253-11262.
26. Bechinger B, Ruysschaert JM, Goormaghtigh E. Membrane helix orientation from linear dichroism of infrared attenuated total reflection spectra. Biophys. J. 1999; 76: 552-563.
27. Kichler A, Leborgne C, Danos O, Bechinger B. Characterization of the gene transfer process mediated by histidine-rich peptides. J. Mol. Med. 2007; 85: 191-201.
28. Vidovic V, Prongidi-Fix L, Bechinger B, Werten S. Production and isotope labeling of antimicrobial peptides in Escherichia coli by means of a novel fusion partner that enables high-yield insoluble expression and fast purification. J. Pept. Sci. 2009; 15: 278-284.
29. Marquette A, Lorber B, Bechinger B. Reversible liposome association induced by LAH4: a peptide with potent antimicrobial and nucleic acid transfection activities. Biophys. J. 2010; 98: 2544-2553.
30. Ziegler A, Blatter XL, Seelig A, Seelig J. Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis. Biochemistry 2003; 42: 9185-9194.
31. Jung S, Dingley AJ, Augustin R, Anton-Erxleben F, Stanisak M, Gelhaus C, Gutsmann T, Hammer MU, Podschun R, Bonvin AM, Leippe M, Bosch TC, Grotzinger J. Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J. Biol. Chem. 2009; 284: 1896-1905.
32. Lehto T, Abes R, Oskolkov N, Suhorutsenko J, Copolovici DM, Mager I, Viola JR, Simonsson O, Ezzat K, Guterstam P, Eriste E, Smith CI, Lebleu B, Samir EA, Langel U. Delivery of nucleic acids with a stearylated (RxR)(4) peptide using a non-covalent co-incubation strategy. J. Controlled Release 2010; 141: 42-51.