T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis

Memorias do Instituto Oswaldo Cruz

Volumn 102, Issue 5, 2007, Pages 625-630

  Bittar, Rita C ^a   Nogueira, Ricardo S ^a   Vieira Gonçalves, Ricardo ^a   Pinho Ribeiro, Vanessa ^a   Mattos, Marise S ^b   Oliveira Neto, Manoel Paes ^b   Coutinho, Sergio G ^a   Da Cruz, Alda M ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Funda??o Oswaldo Cruz   (Brazil)

Author keywords

Asymptomatic infection; Cured leishmaniasis; Cytokines; Leishmania (Viannia) braziliensis; Long term immunity; T cell subsets

Indexed keywords

LEISHMANIA BRAZILIENSIS;

EID: 34547907884     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762007005000069     Document Type: Article

References (36)

1. Bacellar O, Lessa H, Schriefer A, Machado P, Ribeiro de Jesus A, Dutra W, Gollob KJ, Carvalho EM 2002. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 70: 6734-6740.
2. Barral A, Guerreiro J, Bomfim G, Correia D, Barral-Netto M, Carvalho EM 1995. Lymphadenopathy as the first sign of human cutaneous infection by Leishmania braziliensis. Am J Trop Med Hyg 53: 256-259.
3. Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194: 1497-1506.
4. + regulatory T cells control Leishmania major persistence and immunity. Nature 420: 502-507.
5. + T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 168: 3992-4000.
6. Bosque F, Saravia NG, Valderrama L, Milon G 2000. Distinct innate and acquired immune responses to Leishmania in putative susceptible and resistant human populations endemically exposed to L. (Viannia) panamensis infection. Scand J Immunol 51: 533-541.
7. Bottrel RLA, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Neto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ 2001. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun 69: 3232-3239.
8. Brodskyn CI, Barral A, Boaventura V, Carvalho E, Barral-Netto M 1997. Parasite-driven in vitro human lymphocyte cytotoxicity against autologous infected macrophages from mucosal leishmaniasis. J Immunol 159: 4467-4473.
9. Coutinho SG, Oliveira MP, Da-Cruz AM, De-Luca PM, Mendonça SCF, Bertho AL, Soong L, McMahon-Pratt D 1996. T-cell responsiveness of American cutaneous leishmaniasis patients to purified Leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens. Immunologic patterns associated with cure. Exp Parasitol 84: 144-155.
10. Da-Cruz AM, Pirmez C 2005. Leishmaniose tegumentar americana. In JR Coura, Dinâmica das Doenças Infecciosas e Parasitá rias, Guanabara Koogan, Rio de Janeiro, p. 697-712.
11. Da-Cruz AM, Bittar R, Mattos M, Oliveira-Neto MP, Nogueira R, Pinho-Ribeiro V, Azeredo-Coutinho RB, Coutinho SG 2002. T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy. Clin Diagn Lab Immunol 9: 251-256.
12. + T cells associated with cure of human cutaneous leishmaniasis. Infect Immun 62: 2614-2618.
13. Davies CR, Llanos-Cuentas EA, Pyke SDM, Dye C 1995. Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity. Epidemiol Infect 114: 297-318.
14. Follador I, Araújo C, Bacellar O, Araújo CB, Carvalho LP, Almeida RP, Carvalho EM 2002. Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection. Clin Infect Dis 34: 54-58.
15. + memory T cells following Leishmania infection. Trends Parasitol 21: 347-350.
16. Gomes-Silva A, Bittar RC, Nogueira RS, Amato VS, Mattos MS, Oliveira-Neto MP, Coutinho SG, Da-Cruz AM 2007. Can IFN-γ and IL-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection? Clin Exp Immunol, in press.
17. Grimaldi Jr G, McMahon-Pratt D 1991. Leishmaniasis and its etiologic agents in the New World: an overview. Prog Clin Parasitol 2: 73-118.
18. + T cell development. Immunol Today 20: 177-180.
19. + T cells. Parasite Immunol 25: 559-567.
20. Kündig TM, Bachmann MF, Oehen S, Hoffmann UW, Simard JJ, Kalberer CP, Pircher H, Ohashi PS, Hengartner H, Zinkernagel RM 1996. On the role of antigen in maintaining cytotoxic T-cell memory. Proc Natl Acad Sci USA 93: 9716-9723.
21. Louis J, Himmelrich H, Parra-Lopez C, Tacchini-Cottier F, Launois P 1998. Regulation of protective immunity against Leishmania major in mice. Curr Opin Immunol 10: 459-464.
22. Marzochi MCA, Coutinho SG, Sabroza PC, Souza WJS 1980. Reação de imunofluorescência indireta e intradermorreação para leishmaniose tegumentar americana em moradores na área de Jacarepaguá (Rio de Janeiro): estudo comparativo dos resultados observados em 1974 e 1978. Rev Inst Med Trop São Paulo 22: 149-155.
23. + regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med 200: 201-210.
24. MS/SVS-Ministério da Saúde/Secretaria de Vigilância em Saúde 2002. Boletim Eletrônico, Ano 2, no 5. Available at: http://portal.saúde.gov.br/portal/svs; accessed on Jan 31st 2007.
25. Oliveira-Neto MP, Mattos MS, Perez MA, Da-Cruz AM, Fernandes O, Moreira J, Gonçalves-Costa SC, Brahin LR, Menezes CR, Pirmez C 2000. American tegumentary leishmaniasis (ATL) in Rio de Janeiro State, Brazil: main clinical and epidemiologic characteristics. Int J Dermatol 39: 506-514.
26. + T-cell responses. Curr Opin Immunol 16: 259-263.
27. Rocha PN, Almeida RP, Bacellar O, Ribeiro de Jesus A, Correia Filho D, Cruz Filho A, Barral A, Coffman RL, Carvalho EM 1999. Down-regulation of Th1 type of response in early human American cutaneous leishmaniasis. J Infect Dis 180: 1731-1734.
28. Sassi A, Louzir H, Salah AB, Mokni M, Osman AB, Dellagi K 1999. Leishmanin skin test, lymphoproliferative responses and cytokine production after symptomatic or asymptomatic Leishmania major infection in Tunisia. Clin Exp Immunol 116: 127-132.
29. Schubach A, Haddad F, Oliveira-Neto MP, Degrave W, Pirmez C, Grimaldi G, Fernandes O 1998. Detection of Leishmania DNA by the polymerase chain reaction in scars of treated human patients. J Infect Dis 178: 911-914.
30. Scott P, Artis D, Uzonna J, Zaph C 2004. The development of effector and memory T cells in cutaneous leishmaniasis: the implications for vaccine development. Immunol Rev 201: 318-338.
31. Souza WJS, Sabroza PC, Santos CS, Souza E, Henrique MF, Coutinho SG 1992. Montenegro skin tests for American cutaneous leishmaniasis carried out on school children in Rio de Janeiro, Brazil: an indicator of transmission risk. Acta Trop 52: 111-119.
32. Tanchot C, Lemonnier FA, Pérarnau B, Freitas AA, Rocha B 1997. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science 276: 2057-2062.
33. Toledo VPCP, Mayrink W, Gollob KJ, Oliveira MAP, Costa CA, Genaro O, Pinto JA, Afonso LCC 2001. Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment. Mem Inst Oswaldo Cruz 96: 89-98.
34. + T cell memory in response to low, high, and excessive levels of epitope. J Immunol 168: 4455-4461.
35. Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Adrian UH, Ahmed R 2003. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunol 4: 225-234.
36. Zaph C, Uzonna J, Beverley SM, Scott P 2004. Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites. Nature Medicine 10: 1104-1110.