In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 2, 2011, Pages 350-353

  da Luz, Raquel Andreia Inocêncio ^a   Vermeersch, Marieke ^a   Deschacht, Maartje ^a   Hendrickx, Sarah ^a   van Assche, Tim ^a   Cos, Paul ^a   Maes, Louis ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

BALB c; Leishmania major; Leishmania mexicana; Leishmania panamensis

Indexed keywords

ANTIPARASITIC AGENT; PX 6518; SAPONIN DERIVATIVE; STIBOGLUCONATE SODIUM; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG SENSITIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIA PANAMENSIS; MOUSE; NONHUMAN; SKIN LEISHMANIASIS; SPECIES DIFFERENCE;

ANIMALS; ANTIBIOTIC PROPHYLAXIS; ANTIMONY SODIUM GLUCONATE; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; LEISHMANIASIS, VISCERAL; MACROPHAGES; MICE; MICE, INBRED BALB C; SAPONINS; TRITERPENES;

EID: 78651431171     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq444     Document Type: Article

References (10)

1. Maes L, Vanden Berghe D, Germonprez N, et al. In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral Leishmania species. Antimicrob Agents Chemother 2004; 48: 130-6.
2. Maes L, Germonprez N, Quirijnen L, et al. Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B (AmBisome) against Leishmania donovani in hamsters. Antimicrob Agents Chemother 2004; 48: 2056-60.
3. Germonprez N, Maes L, Van Puyvelde L, et al. In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives. J Med Chem 2005; 48: 32-7.
4. Inocêncio da Luz R, Vermeersch M, Dujardin JC,, et al. In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells. Antimicrob Agents Chemother 2009; 53: 5197-203.
5. Vermeersch M, Inocêncio da Luz R, Toté K, et al. In vitro susceptibility of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences. Antimicrob Agents Chemother 2009; 5: 3855-9.
6. Delmas F, Di Giorgio C, Elias R, et al. Antileishmanial activity of three saponins isolated from ivy, a-hederin, b-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. Planta Med 2000; 66: 343-7.
7. Palumbo E. Treatment strategies for mucocutaneous leishmaniasis. J Glob Infect Dis 2010; 2: 147-50.
8. Aguiar MG, Silva DL, Nunan FA, et al. Combined topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) major leads to reduction in both lesion size and systemic parasite burdens. J Antimicrob Chemother 2009; 64: 1234-40.
9. Dutta A, Ghoshal A, Mandal D, et al. Racemoside A, an anti-leishmanial, water-soluble, natural steroidal saponin, induces programmed cell death in Leishmania donovani. J Med Microbiol 2007; 56: 1196-204.
10. Vermeersch M, Foubert K, Inocê ncio da Luz R, et al. Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae. Phytother Res 2009; 23: 1404-10.