In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives

Journal of Medicinal Chemistry

Volumn 48, Issue 1, 2005, Pages 32-37

  Germonprez, Nils ^a   Maes, Louis ^b   Van Puyvelde, Luc ^a,c   Van Tri, Mai ^c   Tuan, Duong Anh ^c   De Kimpe, Norbert ^d  

^a TIBOTEC BVBA   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c INSTITUTE OF CHEMISTRY   (Viet Nam)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 BETA O [[ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO RHAMNOPYRANOSYL (1-2) BETA DEXTRO GALACTOPYRANOSYL (1-3)] [BETA DEXTRO GALACTOPYRANOSYL (1-2)] BETA DEXTRO GLUCURONOPYRANOSYL] 16ALPHA,21BETA,22ALPHA,13BETA,28 OXIDOOLEAN 28ALPHA TETROL; ANTILEISHMANIAL AGENT; MAESABALIDE DERIVATIVE; MAESABALIDE I; MAESABALIDE II; MAESABALIDE III; MAESABALIDE IV; MAESABALIDE V; MAESABALIDE VI; SAPONIN DERIVATIVE; STIBOGLUCONATE SODIUM; TRITERPENOID; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DERIVATIZATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG PURIFICATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA INFANTUM; MEDICINAL PLANT; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPROTOZOAL AGENTS; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LIVER; MALE; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 12144255598     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031150y     Document Type: Article

References (13)

1. Maes, L.; Germonprez, N.; Van Puyvelde, L.; Van Tri, M.; Ngoc Ninh, T.; De Kimpe, N. Antiprotozoal saponins. International Patent WO 00/38700, July 2000.
2. Pham Hoang Ho, Cay co Vietnam (an illustrated Flora of Vietnam); NHA XUAT BAN TRE, Vietnam, 1999; Vol. 1, p 675.
3. Vo Van Chi, Tu dien cay thuoc Vietnam; NHA XUAT BAN Y HOC, Vietnam, 1997; p 489.
4. Maes, L.; Vanden Berghe, D.; Germonprez, N.; Quirijnen, L.; Cos, P.; De Kimpe, N.; Van Puyvelde, L. In vitro and in vivo activity of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral Leishmania species. Antimicrob. Agents Chemother. 2004, 48, 130-136.
5. Germonprez, N.; Van Puyvelde, L.; Maes, L.; De Kimpe, N. New pentacyclic triterpene saponins with strong antileishmanial activity from the leaves of Maesa balansae. Tetrahedron 2004, 60, 219-228.
6. Desjeux, P. The increase in risk factors for leishmaniasis worldwide. Trans. R. Soc. Trop. Med. Hyg. 2001, 95, 239-243.
7. Guerin, P.; Olliaro, J. P.; Sundar, S.; Boelaert, M.; Croft, S. L.; Desjeux, P.; Wasunna, M. K.; Bryceson, A. D. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect. Dis. 2002, 2, 494-501.
8. 1, in association with pentamidine and amphotericin B. Phytother. Res. 2001, 15, 298-301.
9. Okunji, C. O.; Iwu, M. M.; Jackson, J. E.; Tally, J. D. Biological activity of saponins from two Dracaena species. Adv. Exp. Med. Biol. 1996, 404, 415-428.
10. Plock, A.; Sokolowska-Kohler, W.; Presber, W. Application of flow cytometry and microscopical methods to characterize the effect of herbal drugs on Leishmania spp. Exp. Parasitol. 2001, 97, 141-153.
11. Del Rayo Camancho Corona, M.; Croft, S. L.; Phillipson, J. D. Natural sources of antiprotozoal drugs. Curr. Opin. Anti-Infect. Invest. Drugs 2000, 2, 47-62.
12. Hostettmann, K.; Marston, A. Saponins. In Chemistry & Pharmacology of Natural Products; Cambridge University Press: London, 1995; pp 239-284.
13. O'Brien, J.; Wilson, I.; Orton, T.; Pognan, F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 2000, 267, 5421-5426.