Normal prion protein in Drosophila enhances the toxicity of pathogenic polyglutamine proteins and alters susceptibility to oxidative and autophagy signaling modulators

Biochemical and Biophysical Research Communications

Volumn 404, Issue 2, 2011, Pages 638-645

  Park, Yunwoong ^a   Kim, Wontae ^a,b   Kim, A Young ^a   Choi, Hee Jung ^a   Choi, Jin Kyue ^a   Park, NamSin ^c   Koh, Eui Kwan ^c   Seo, Jongbok ^c   Koh, Young Ho ^a  

^a Hallym University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Autophagy; Drosophila; ER stress; Oxidative stress; Polyglutamine; Prion protein

Indexed keywords

3 METHYLADENINE; DITHIOTHREITOL; HYDROGEN PEROXIDE; PARAQUAT; POLYGLUTAMINE; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; DROSOPHILA; EYE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MACHADO JOSEPH DISEASE; MOUSE; NEUROTOXICITY; NONHUMAN; PATHOGENICITY; PRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; WESTERN BLOTTING;

ADENINE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; DISEASE MODELS, ANIMAL; DITHIOTHREITOL; DROSOPHILA MELANOGASTER; EYE; LITHIUM CHLORIDE; MACHADO-JOSEPH DISEASE; MICE; MODELS, GENETIC; NEURONS; OXIDATIVE STRESS; PARAQUAT; PEPTIDES; PRIONS; UNFOLDED PROTEIN RESPONSE; WATER;

EID: 78651365764     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.12.030     Document Type: Article

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