Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate

Molecular Pharmacology

Volumn 79, Issue 1, 2011, Pages 51-60

  Leitner, Michael G ^a   Halaszovich, Christian R ^a   Oliver, Dominik ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; ANTIBIOTIC G 418; GENTAMICIN; KANAMYCIN; NEOMYCIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POLYLYSINE; POTASSIUM CHANNEL KCNQ4; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; COCHLEA; CONTROLLED STUDY; DRUG POTENCY; HAIR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OTOTOXICITY; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

AMINOGLYCOSIDES; ANIMALS; CHO CELLS; COCHLEA; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HAIR CELLS, AUDITORY, OUTER; KCNQ POTASSIUM CHANNELS; MEMBRANE POTENTIALS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; RATS; RATS, WISTAR;

EID: 78651345715     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.068130     Document Type: Article

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