Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

Journal of Biosciences

Volumn 35, Issue 4, 2010, Pages 501-505

  Swarup, Ghanshyam ^a   Nagabhushana, Ananthamurthy ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

ALS; glaucoma; NF B signalling; optineurin; vesicle trafficking

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; METABOTROPIC RECEPTOR; OPTINEURIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; CELL MEMBRANE; CELL MIGRATION; ENZYME ACTIVITY; EXOCYTOSIS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GLAUCOMA; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MISSENSE MUTATION; NONHUMAN; NOTE; PRIMARY MOTOR CORTEX; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; TRANSGENE; UBIQUITINATION;

AMYOTROPHIC LATERAL SCLEROSIS; CELL MEMBRANE; DOWN-REGULATION; GLAUCOMA; HUMANS; INTERFERON-BETA; MUTATION; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RNA VIRUS INFECTIONS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR TFIIIA; UBIQUITINATION;

EID: 78651343770     PISSN: 02505991     EISSN: 02505991     Source Type: Journal    
DOI: 10.1007/s12038-010-0056-9     Document Type: Note

References (28)

1. O. M. Albagha M. R. Visconti N. Alonso A. L. Langston T. Cundy R. Dargie M. G. Dunlop W. D. Fraser, et al. 2010 Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone Nat. Genet. 42 520 524 1:CAS:528:DC%2BC3cXlsVyitbg%3D 10.1038/ng.562 20436471
2. P. H. Anborgh C. Godin M. Pampillo G. K. Dhami L. B. Dale S. P. Cregan R. Truant S. S. Ferguson 2005 Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin J. Biol. Chem. 280 34840 34848 1:CAS:528:DC%2BD2MXhtVyks77P 10.1074/jbc.M504508200 16091361 (Pubitemid 41504618)
3. M. L. Chalasani V. Radha V. Gupta N. Agarwal D. Balasubramanian G. Swarup 2007 A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants Invest Ophthalmol. Vis. Sci. 48 1607 1614 10.1167/iovs.06-0834 17389490 (Pubitemid 351261344)
4. M. L. Chalasani G. Swarup D. Balasubramanian 2009 Optineurin and its mutants: molecules associated with some forms of glaucoma Ophthalmic Res 42 176 184 1:CAS:528:DC%2BD1MXhsFWrsrzM 10.1159/000232400 19672125
5. Z. L. Chi M. Akahori M. Obazawa M. Minami T. Noda N. Nakaya S. Tomarev K. Kawase, et al. 2010 Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice Hum. Mol. Genet 19 2606 2615 1:CAS:528:DC%2BC3cXntlCqurs%3D 10.1093/hmg/ddq146 20388642
6. Chibalina M V, Poliakov A, Kendrick-Jones J and Buss F 2010 Myosin VI and optineurin are required for polarised EGFR delivery and directed migration; Traffic (Epublication ahead of print)
7. D. del Toro J. Alberch F. Lazaro-Dieguez R. Martin-Ibanez X. Xifro G. Egea J. M. Canals 2009 Mutant Huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus Mol. Biol. Cell 20 1478 1492 10.1091/mbc.E08-07-0726 19144827
8. K. Hattula J. Peränen 2000 FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis Curr. Biol 10 1603 1606 1:CAS:528:DC%2BD3cXovFKguro%3D 10.1016/S0960-9822(00)00864-2 11137014 (Pubitemid 32062664)
9. M.S. Hayden S. Ghosh 2008 Shared principles in NF-κB signalling Cell 132 344 362 1:CAS:528:DC%2BD1cXivVahtbY%3D 10.1016/j.cell.2008.01.020 18267068 (Pubitemid 351192002)
10. C. Journo J. Filipe F. About S. A. Chevalier P. V. Afonso J. N. Brady D. Flynn F. Tangy, et al. 2009 NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein PLoS Pathog 5 e1000521 10.1371/journal.ppat.1000521 19609363
11. J. Mankouri R. Fragkoudis K. H. Richards L. F. Wetherill M. Harris A. Kohl R. M. Elliott A. Macdonald 2010 Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection PLoS Pathog 6 e1000778 10.1371/journal.ppat.1000778 20174559
12. H. Maruyama H. Morino H. Ito Y. Izumi H. Kato Y. Watanabe Y. Kinoshita M. Kamada, et al. 2010 Mutations of optineurin in amyotrophic lateral sclerosis Nature (London) 465 223 226 1:CAS:528:DC%2BC3cXltlWmtr8%3D 10.1038/nature08971
13. M. P. Mattson M. K. Meffert 2006 Roles for NF-κB in nerve cell survival, plasticity, and disease Cell Death Differ. 13 852 860 1:CAS:528:DC%2BD28XjsFWisLc%3D 10.1038/sj.cdd.4401837 16397579
14. S. Monemi G. Spaeth A. DaSilva S. Popinchalk E. Ilitchev J. Liebmann R. Ritch E. Héon, et al. 2005 Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1 Hum. Mol. Genet 14 725 733 1:CAS:528:DC%2BD2MXitVCnu7g%3D 10.1093/hmg/ddi068 15677485 (Pubitemid 40403270)
15. S. Morton L. Hesson M. Peggie P. Cohen 2008 Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma FEBS Lett 582 997 1002 1:CAS:528:DC%2BD1cXivFyiur8%3D 10.1016/j.febslet.2008.02. 047 18307994
16. A. Nagabhushana M. L. Chalasani N. Jain V. Radha N. Rangaraj D. Balasubramanian G. Swarup 2010 Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant BMC Cell Biol 11 4 10.1186/1471-2121-11-4 20085643
17. B. Park H. Ying X. Shen J. S. Park Y. Qiu R. Shyam B.Y. Yue 2010 Impairment of protein trafficking upon overexpression and mutation of optineurin PLoS One 5 e11547 10.1371/journal.pone.0011547 20634958
18. B. C. Park X. Shen M. Samaraweera B.Y. Yue 2006 Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types Am. J. Pathol. 169 1976 1989 1:CAS:528:DC%2BD2sXhvV2htg%3D%3D 10.2353/ajpath.2006.060400 17148662 (Pubitemid 351181959)
19. M. E. Pease S. J. McKinnon H. A. Quigley L. A. Kerrigan-Baumrind D. J. Zack 2000 Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma Invest Ophthalmol. Vis. Sci 41 764 774 1:STN:280:DC%2BD3c7nsVygtg%3D%3D 10711692
20. H. A. Quigley 1999 Neuronal death in glaucoma Prog. Retin. Eye Res 18 39 57 1:STN:280:DyaK1M7hslahtA%3D%3D 10.1016/S1350-9462(98)00014-7 9920498 (Pubitemid 28457038)
21. K. Ray S. Mookherjee 2009 Molecular complexity of primary open angle glaucoma: current concept J. Genet. 88 451 467 1:CAS:528:DC%2BC3cXjtVSqsLg%3D 10.1007/s12041-009-0065-3 20090207
22. T. Rezaie A. Child R. Hitchings G. Brice L. Miller M. Coca-Prados E. Heon T. Krupin, et al. 2002 Adult-onset primary open-angle glaucoma caused by mutations in optineurin Science 295 1077 1079 1:CAS:528:DC%2BD38Xht1GqsLo%3D 10.1126/science.1066901 11834836 (Pubitemid 34132238)
23. D. A. Sahlender R. C. Roberts S. D. Arden G. Spudich M. J. Taylor J. P. Luzio J. Kendrick-Jones F. Buss 2005 Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis J. Cell Biol. 169 285 295 1:CAS:528:DC%2BD2MXjslartr0%3D 10.1083/jcb.200501162 15837803 (Pubitemid 40656566)
24. C. Sudhakar A. Nagabhushana N. Jain G. Swarup 2009 NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB PLoS One 4 e5114 10.1371/journal.pone.0005114 19340308
25. E. M. Stone J. H. Fingert W. L. Alward T. D. Nguyen J. R. Polansky S. L. F. Sunden D. Nishimura A. F. Clark, et al. 1997 Identification of a gene that causes primary open angle glaucoma Science 275 668 670 1:CAS:528: DyaK2sXptV2lsw%3D%3D 10.1126/science.275.5300.668 9005853 (Pubitemid 27061334)
26. N. Weisschuh M. V. Alavi M. Bonin B. Wissinger 2007 Identification of genes that are linked with optineurin expression using a combined RNAi-microarray approach Exp. Eye Res 85 450 461 1:CAS:528:DC%2BD2sXhtFGrsrjN 10.1016/j.exer.2007.06.012 17663987 (Pubitemid 47531732)
27. H. Ying X. Shen B. Park B.Y. Yue 2010 Posttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma gene PLoS One 5 e9168 10.1371/journal.pone.0009168 20161783
28. G. Zhu C. J. Wu Y. Zhao J. D. Ashwell 2007 Optineurin negatively regulates TNFα-inducedNF-κB activation by competing with NEMO for ubiquitinated RIP Curr. Biol 17 1438 1443 1:CAS:528:DC%2BD2sXpt1Kns74%3D 10.1016/j.cub.2007.07.041 17702576 (Pubitemid 47259388)