1,25-Dihydroxyvitamin D3-induced aortic calcifications in experimental uremia: Up-regulation of osteoblast markers, calcium-transporting proteins and osterix

Journal of Hypertension

Volumn 29, Issue 2, 2011, Pages 339-348

  Zebger Gong, Hong ^a   Müller, Dominik ^a   Diercke, Michaela ^a   Haffner, Dieter ^b   Hocher, Berthold ^a,c   Verberckmoes, Steven ^d   Schmidt, Sven ^a   D'Haese, Patrick C ^d   Querfeld, Uwe ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c UNIVERSITY OF POTSDAM   (Germany)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

calbindin D9k; calcitriol; calcium transport; osteoblast; osterix; TRPV5; TRPV6; vascular calcification

Indexed keywords

BIOLOGICAL MARKER; BONE SIALOPROTEIN; CALBINDIN; CALCITRIOL; CALCIUM; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR OSTERIX; VANILLOID RECEPTOR 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD VESSEL CALCIFICATION; CALCIUM TRANSPORT; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MINERALIZATION; NEPHRECTOMY; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; UREMIA; VASCULAR SMOOTH MUSCLE;

EID: 78651342326     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328340aa30     Document Type: Article

References (51)

1. Teng M, Wolf M, Ofsthun MN, Lazarus JM, Hernan MA, Camargo CA Jr, Thadhani R. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005; 16:1115-1125.
2. Shoji T, Shinohara K, Kimoto E, Emoto M, Tahara H, Koyama H, et al. Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population. Nephrol Dial Transplant 2004; 19:179-184.
3. Mizobuchi M, Finch JL, Martin DR, Slatopolsky E. Differential effects of vitamin D receptor activators on vascular calcification in uremic rats. Kidney Int 2007; 72:709-715.
4. Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Abnormal carotid artery structure and function in children and adolescents with successful renal transplantation. Circulation 2004; 110:97-101.
5. Civilibal M, Caliskan S, Adaletli I, Oflaz H, Sever L, Candan C, et al. Coronary artery calcifications in children with end-stage renal disease. Pediatric Nephrol (Berlin, Germany) 2006; 21:1426-1433.
6. Shroff RC, Donald AE, Hiorns MP, Watson A, Feather S, Milford D, et al. Mineral metabolism and vascular damage in children on dialysis. J Am Soc Nephrol 2007; 18:2996-3003.
7. Zittermann A, Schleithoff SS, Koerfer R. Vitamin D and vascular calcification. Curr Opin Lipidol 2007; 18:41-46.
8. Shroff R, Egerton M, Bridel M, Shah V, Donald AE, Cole TJ, et al. A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol 2008; 19:1239-1246.
9. Teng M, Wolf M, Lowrie E, Ofsthun N, Lazarus JM, Thadhani R. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med 2003; 349:446-456.
10. Mathew S, Lund RJ, Chaudhary LR, Geurs T, Hruska KA. Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol 2008; 19:1509-1519.
11. Moe SM, Duan D, Doehle BP, O'Neill KD, Chen NX. Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int 2003; 63:1003-1011.
12. Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, et al. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 2008; 118:1748-1757; CIRCULATIONAHA.108. 783738 [pii] [10.1161/ CIRCULATIONAHA.108.783738.
13. Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 2003; 23:489-494.
14. Haffner D, Hocher B, Muller D, Simon K, Konig K, Richter CM, et al. Systemic cardiovascular disease in uremic rats induced by 1,25(OH)2D3. J Hypertens 2005; 23:1067-1075.
15. Franks DJ, Plamondon J, Hamet P. An increase in adenylate cyclase activity precedes DNA synthesis in cultured vascular smooth muscle cells. J Cell Physiol 1984; 119:41-45.
16. Zhu Z, Tepel M, Neusser M, Mehring N, Zidek W. Effect of captopril on vasoconstriction and Ca2\+ fluxes in aortic smooth muscle. Hypertension 1993; 22:806-811.
17. Bendhack LM, Sharma RV, Bhalla RC. Altered signal transduction in vascular smooth muscle cells of spontaneously hypertensive rats. Hypertension 1992; 19:II142-II148.
18. Meijerink J, Mandigers C, van de Locht L, Tonnissen E, Goodsaid F, Raemaekers J. A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR. J Mol Diagn 2001; 3:55-61.
19. Radonic A, Thulke S, Mackay IM, Landt O, Siegert W, Nitsche A. Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun 2004; 313:856-862.
20. Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, et al. Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood 2003; 101:1270-1276.
21. Koleganova N, Piecha G, Ritz E, Gross ML. Calcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats. Nephrol Dial Transplant 2009; 24:778-787.
22. Koleganova N, Piecha G, Ritz E, Schmitt CP, Gross ML. A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia. Kidney Int 2009; 75:60-71.
23. de Oliveira PT, Zalzal SF, Irie K, Nanci A. Early expression of bone matrix proteins in osteogenic cell cultures. J Histochem Cytochem 2003; 51:633-641.
24. Ganss B, Kim RH, Sodek J. Bone sialoprotein. Crit Rev Oral Biol Med 1999; 10:79-98.
25. Wada T, McKee MD, Steitz S, Giachelli CM. Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin. Circ Res 1999; 84:166-178.
26. Scatena M, Liaw L, Giachelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 2007; 27:2302-2309.
27. Jono S, Nishizawa Y, Shioi A, Morii H. 1,25-Dihydroxyvitamin D3 increases in vitro vascular calcification by modulating secretion of endogenous parathyroid hormone-related peptide. Circulation 1998; 98:1302-1306.
28. Hunter GK, Goldberg HA. Nucleation of hydroxyapatite by bone sialoprotein. Proc Natl Acad Sci USA 1993; 90:8562-8565.
29. Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, et al. Bonespecific transcription factor Runx2 interacts with the 1alpha,25- dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Molec Cell Biol 2004; 24:8847-8861.
30. Naveh-Many T, Marx R, Keshet E, Pike JW, Silver J. Regulation of 1,25- dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo. J Clin Invest 1990; 86:1968-1975.
31. Healy KD, Zella JB, Prahl JM, DeLuca HF. Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium. Proc Natl Acad Sci USA 2003; 100:9733-9737.
32. Carrillo-Lopez N, Alvarez-Hernandez D, Gonzalez-Suarez I, Roman-Garcia P, Valdivielso JM, Fernandez-Martin JL, Cannata-Andia JB. Simultaneous changes in the calcium-sensing receptor and the vitamin D receptor under the influence of calcium and calcitriol. Nephrol Dial Transplant 2008; 23:3479-3484.
33. Klaus G, von Eichel B, May T, Hugel U, Mayer H, Ritz E, Mehls O. Synergistic effects of parathyroid hormone and 1,25-dihydroxyvitamin D3 on proliferation and vitamin D receptor expression of rat growth cartilage cells. Endocrinology 1994; 135:1307-1315.
34. Chung I, Wong MK, Flynn G, Yu WD, Johnson CS, Trump DL. Differential antiproliferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cells. Cancer Res 2006; 66:8565-8573.
35. Nibbelink KA, Tishkoff DX, Hershey SD, Rahman A, Simpson RU. 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte. J Steroid Biochem Molec Biol 2007; 103:533-537.
36. Koyama H, Nishizawa Y, Inaba M, Hino M, Prahl JM, DeLuca HF, Morii H. Impaired homologous upregulation of vitamin D receptor in rats with chronic renal failure. Am J Physiol 1994; 266:F706-F712.
37. Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, Bindels RJ. Molecular identification of the apical Ca2\+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem 1999; 274:8375-8378.
38. Hoenderop JG, Hartog A, Stuiver M, Doucet A, Willems PH, Bindels RJ. Localization of the epithelial Ca(2\+) channel in rabbit kidney and intestine. J Am Soc Nephrol 2000; 11:1171-1178.
39. Hoenderop JG, van der Kemp AW, Urben CM, Strugnell SA, Bindels RJ. Effects of vitamin D compounds on renal and intestinal Ca2\+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Kidney Int 2004; 66:1082-1089.
40. Weber K, Erben RG, Rump A, Adamski J. Gene structure and regulation of the murine epithelial calcium channels ECaC1 and 2. Biochem Biophys Res Commun 2001; 289:1287-1294.
41. Nijenhuis T, Hoenderop JG, Bindels RJ. TRPV5 and TRPV6 in Ca(2\+) (re)absorption: regulating Ca(2\+) entry at the gate. Pflugers Arch 2005; 451:181-192.
42. van der Eerden BC, Hoenderop JG, de Vries TJ, Schoenmaker T, Buurman CJ, Uitterlinden AG, et al. The epithelial Ca2\+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci USA 2005; 102:17507-17512.
43. Balmain N, von Eichel B, Toury R, Belquasmi F, Hauchecorne M, Klaus G, et al. Calbindin-D28K and -D9K and 1,25(OH)2 vitamin D3 receptor immunolocalization and mineralization induction in long-term primary cultures of rat epiphyseal chondrocytes. Bone 1995; 17:37-45.
44. Balmain N, Hotton D, Cuisinier-Gleizes P, Mathieu H. Immunoreactive calbindin-D9K localization in matrix vesicle-initiated calcification in rat epiphyseal cartilage: an immunoelectron microscope study. J Bone Miner Res 1989; 4:565-575.
45. Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocrine Rev 2000; 21:393-411.
46. Mizobuchi M, Ogata H, Hatamura I, Koiwa F, Saji F, Shiizaki K, et al. Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism. Nephrol Dial Transplant 2006; 21:911-916.
47. Drissi H, Pouliot A, Koolloos C, Stein JL, Lian JB, Stein GS, van Wijnen AJ. 1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter. Exp Cell Res 2002; 274:323-333.
48. Maehata Y, Takamizawa S, Ozawa S, Kato Y, Sato S, Kubota E, Hata R. Both direct and collagen-mediated signals are required for active vitamin D3-elicited differentiation of human osteoblastic cells: roles of osterix, an osteoblast-related transcription factor. Matrix Biol 2006; 25:47-58.
49. Baek WY, Lee MA, Jung JW, Kim SY, Akiyama H, de Crombrugghe B, Kim JE. Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix. J Bone Miner Res 2009; 24:1055-1065.
50. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002; 108:17-29.
51. Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 2009; 20:1453-1464.