1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter

Experimental Cell Research

Volumn 274, Issue 2, 2002, Pages 323-333

  Drissi, Hicham ^a   Pouliot, Arlyssa ^a   Koolloos, Christian ^a   Stein, Janet L ^a   Lian, Jane B ^a   Stein, Gary S ^a   Van Wijnen, André J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

1,25 (OH)2 vitamin D3; Gene expression; Osteoblast; Promoter; Runx2 Cbfa1; Transcription

Indexed keywords

ANTIBODY; CALCITRIOL; DIMER; OLIGONUCLEOTIDE; RETINOID X RECEPTOR; STEROID HORMONE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL STRAIN; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; IN VIVO STUDY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; TISSUE SPECIFICITY;

EID: 0036343579     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5474     Document Type: Article

References (62)

1. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
2. Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): Evidence for a new myc collaborating oncogene
3. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
4. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
5. Runt homology domain proteins in osteoblast differentiation: AML-3/CBFA1 is a major component of a bone specific complex
6. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
7. Cbfa1 isoforms exert functional differences in osteoblast differentiation
8. Cbfa1 isoform overexpression upregulates osteocalcin gene expression in non-osteoblastic and pre-osteoblastic cells
9. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
10. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
11. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
12. DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsive to 1,25-dihydroxyvitamin D3
13. Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene
14. Species-divergent regulation of human and mouse osteocalcin genes by calciotropic hormones
15. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression
16. Regulation of bone sialoprotein and osteopontin mRNA expression by dexamethasone and 1,25-dihydroxyvitamin D3 in rat bone organ cultures
17. 1,25-Dihydroxyvitamin D3 inhibits transcription of type I collagen genes in the rat osteosarcoma cell line ROS 17/2.8
18. The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function
19. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter
20. Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene
21. Cbfa1 does not activate rat Col1a1 promoter expression in ROS 17/2.8 cells
22. runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: Evidence for promoter context-dependent activity of Cbfa proteins
23. Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene
24. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D responsive transcription and contribute to chromatin organization
25. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways
26. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
27. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between runx2 and smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
28. Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
29. Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins
30. Crosstalk between 1,25-dihydroxyvitamin D3 and transforming growth factor-beta signaling requires binding of VDR and Smad3 proteins to their cognate DNA recognition elements
31. Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-MO)
32. The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts
33. AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: Requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation
34. Characterization of the upstream mouse Cbfa1/Runx2 promoter
35. YY1 regulates VDR/RXR mediated transactivation of the vitamin D responsive osteocalcin gene
36. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
37. Identification of DNA sequences that bind retinoid X receptor-1,25(OH)2D3-receptor heterodimers with high affinity
38. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer
39. Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: Reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements
40. In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells
41. The vitamin D-responsive element in the rat bone Gla protein gene is an imperfect direct repeat that cooperates with other cis-elements in 1,25-dihydroxyvitamin D3-mediated transcriptional activation
42. 3
43. 1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice
44. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3
45. Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor
46. Characterization of a response element in the 5′-flanking region of the avian (chicken) PTH gene that mediates negative regulation of gene transcription by 1,25-dihydroxyvitamin D3 and binds the vitamin D3 receptor
47. DNA sequences in the rat parathyroid hormone-related peptide gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression
48. Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene
49. Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: Dexamethasone inhibits osteoblast differentiation and vitamin D downregulates osteocalcin gene expression
50. Identification of a vitamin D3-response element that overlaps a unique inverted TATA box in the rat bone sialoprotein gene
51. Turning a negative into a positive: Vitamin D receptor interactions with the avian parathyroid hormone response element
52. Vitamin D receptor interactions with positive and negative DNA response elements: An interference footprint comparison
53. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
54. Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin D3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element
55. Genomic cloning, structure, and regulatory elements of the 1 alpha, 25(OH)2D3 down-regulated gene for cyclic AMP-dependent protein kinase inhibitor
56. Mechanisms of gene regulation by vitamin D(3) receptor: A network of coactivator interactions
57. Agonist-triggered modulation of the activated and silent state of the vitamin D(3) receptor by interaction with co-repressors and co-activators
58. Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene
59. Coordinate occupancy of AP-1 sites in the vitamin D responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: Model for phenotype suppression of transcription
60. Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: Role of fra-2 and jun D during differentiation
61. Potential role of Cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: Regulation of mRNA expression of osteoclast differentiation factor (ODF)