Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 1, 2011, Pages

  Chitravanshi, Vineet C ^a   Sapru, Hreday N ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Corticotropin releasing factor receptors; Vagus

Indexed keywords

5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GLUTAMIC ACID; IONOTROPIC RECEPTOR ANTAGONIST; URETHAN; UROCORTIN I;

AMBIGUUS NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; BRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DECEREBRATION; HEART; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; MICROINJECTION; NONHUMAN; PARASYMPATHETIC INNERVATION; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; VAGOTOMY;

ANALYSIS OF VARIANCE; ANILINE COMPOUNDS; ANIMALS; BAROREFLEX; BLOOD PRESSURE; BRADYCARDIA; DECEREBRATE STATE; GLUTAMIC ACID; HEART RATE; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NEURONS; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; UROCORTINS; VAGUS NERVE;

EID: 78651320927     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00391.2010     Document Type: Article

References (46)

1. Baram TZ, Chalmers DT, Chen C, Koutsoukos Y, De Souza EB. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res 770: 89-95, 1997.
2. Bieger D, Hopkins DA. Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus. J Comp Neurol 262: 546-562, 1987.
3. Bindslev N. A homotropic two-state model and auto-antagonism. BMC Pharmacol 4: 11-22, 2004.
4. Bittencourt JC, Vaughan J, Arias C, Riesman RA, Vale WW, Sawchenko PE. Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol 415: 285-312, 1999.
5. Chen C, Dagnino R Jr, De Souza EB, Grigoriadis DE, Huang CQ, Kim KI, Liu Z, Moran T, Webb TR, Whitten JP, Xie YF, McCarthy JR. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. Med Chem 39: 4358-4360, 1996.
6. Cheng SB, Hayakawa T, Kuchiiwa S, Maeda S, Ito H, Seki M, Nakagawa S. Evidence for the collateral innervation of the esophagus and the heart from neurons in the compact formation of the nucleus ambiguus of the rat. Brain Res 832: 171-174, 1999.
7. Chitravanshi VC, Bhatt S, Sapru HN. Microinjections of alpha-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardia. Am J Physiol Regul Integr Comp Physiol 296: R1402-R1411, 2009.
8. Dautzenberg FM, Hauger RL. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol Sci 23: 71-77, 2002.
9. Davis ME, Pemberton CJ, Yandle TG, Fisher SF, Lainchbury JG, Frampton CM, Rademaker MT, Richards AM. Urocortin 2 infusion in healthy humans: hemodynamic, neurohormonal, and renal responses. J Am Coll Cardiol 49: 461-471, 2007.
10. Dieterle T, Meili-Butz S, Buhler K, Morandi C, John D, Buser PT, Rivier J, Vale WW, Peterson KL, Brink M. Immediate and sustained blood pressure lowering by urocortin 2: a novel approach to antihypertensive therapy? Hypertension 53: 739-744, 2009.
11. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. Cloning and characterization of human urocortin. Endocrinology 137: 2167-2170, 1996.
12. Drolet G, Rivest S. Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo. Peptides 22: 761-767, 2001.
13. Griffioen KJ, Venkatesan P, Huang ZG, Wang X, Bouairi E, Evans C, Gold A, Mendelowitz D. Fentanyl inhibits GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res 1007: 109-115, 2004. (Pubitemid 38520178)
14. Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM. International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotrophin releasing factor and their ligands. Pharmacol Rev 55: 21-26, 2003.
15. Hsu SY, Hsueh AJ. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med 7: 605-611, 2001.
16. Kasamatsu K, Chitravanshi VC, Sapru HN. Depressor and bradycardic responses to microinjections of endomorphin-2 into the nucleus tractus solitarius are mediated via ionotropic glutamate receptors. Am J Physiol Regul Integr Comp Physiol 287: R715-R728, 2004.
17. Kozicz T, Yanaihara H, Arimura A. Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J Comp Neurol 391: 1-10, 1998.
18. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci USA 98: 7570-7575, 2001.
19. Li C, Vaughan J, Sawchenko PE, Vale WW. Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression. J Neurosci 22: 991-1001, 2002.
20. Li X, Fan M, Shen L, Cao Y, Zhu D, Hong Z. Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat. Auton Neurosci 154: 108-111, 2010.
21. McAllen RM, Spyer KM. Two types of vagal preganglionic motoneurones projecting to the heart and lungs. J Physiol 282: 353-364, 1978.
22. Mendelowitz D. Advances in parasympathetic control of heart rate and cardiac function. News Physiol Sci 14: 155-161, 1999.
23. Morin SM, Ling N, Liu XJ, Kahl SD, Gehlert DR. Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain. Neuroscience 92: 281-291, 1999.
24. Nakamura T, Sapru HN. Cardiovascular responses to microinjections of urocortins into the NTS: role of ionotropic glutamate receptors. Am J Physiol Heart Circ Physiol 296: H2022-H2029, 2009.
25. Nakamura T, Kawabe K, Sapru HN. Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat. Am J Physiol Heart Circ Physiol 296: H325-H332, 2009.
26. Nosaka S, Yamamoto T, Yasunaga K. Localization of vagal cardioinhibitory preganglionic neurons within rat brain stem. J Comp Neurol 186:79-92, 1979.
27. Nosaka S, Yasunaga K, Tamai S. Vagal cardiac preganglionic neurons: distribution, cell types, and reflex discharges. Am J Physiol Regul Integr Comp Physiol 243: R92-R98, 1982.
28. Pan W, Kastin AJ. Urocortin and the brain. Prog Neurobiol 84: 148-156, 2008.
29. Rademaker MT, Cameron VA, Charles CJ, Richards AM. Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. Circulation 112: 3624-3632, 2005.
30. Rademaker MT, Charles CJ, Espiner EA, Frampton CM, Lainchbury JG, Richards AM. Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. Eur Heart J 26: 2055-2062, 2005.
31. Rademaker MT, Cameron VA, Charles CJ, Richards AM. Urocortin 3: haemodynamic, hormonal, and renal effects in experimental heart failure. Eur Heart J 27: 2088-2098, 2006.
32. Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughan J, Arias CA, Hogenesch JB, Gulyas J, Rivier J, Vale WW, Sawchenko PE. Urocortin II: a member of the corticotropin releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci USA 98: 2843-2848, 2001.
33. Ryabinin AE, Tsivkovskaia NO, Ryabinin SA. Urocortin 1-containing neurons in the human Edinger-Westphal nucleus. Neuroscience 134:1317-1323, 2005.
34. Ryabinin AE, Weitemier AZ. The urocortin 1 neurocircuit: ethanol-sensitivity and potential involvement in alcohol consumption. Brain Res Rev 52: 368-380, 2006.
35. Sapru HN. Glutamate circuits in selected medullo-spinal areas regulating cardiovascular function. Clin Exp Pharmacol Physiol 29: 491-496, 2002.
36. Schreihofer AM, Guyenet PG. The baroreflex and beyond: control of sympathetic vasomotor tone by GABAergic neurons in the ventrolateral medulla. Clin Exp Pharmacol Physiol 29: 514-521, 2002.
37. Takanaga A, Hayakawa T, Tanaka K, Kawabata K, Maeda S, Seki M. Immunohistochemical characterization of cardiac vagal preganglionic neurons in the rat. Auton Neurosci 106: 132-137, 2003.
38. Van Pett K, Viau V, Bittencourt JC, Chan RK, Li HY, Arias C, Prins GS, Perrin M, Vale W, Sawchenko PE. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428: 191-212, 2000.
39. Vasconcelos LA, Donaldson C, Sita LV, Casatti CA, Lotfi CF, Wang L, Cadinouche MZ, Frigo L, Elias CF, Lovejoy DA, Bittencourt JC. Urocortin in the central nervous system of a primate (Cebus apella): sequencing, immunohistochemical, and hybridization histochemical characterization. J Comp Neurol 463: 157-175, 2003.
40. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378: 287-292, 1995.
41. Venkatasubramanian S, Newby DE, Lang NN. Urocortins in heart failure. Biochem Pharmacol 80: 289-296, 2010.
42. Wang B, You ZB, Rice KC, Wise RA. Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl) 193: 283-294, 2007.
43. Wang J, Irnaten M, Neff RA, Venkatesan P, Evans C, Loewy AD, Mettenleiter TC, Mendelowitz D. Synaptic and neurotransmitter activation of cardiac vagal neurons in the nucleus ambiguus. Ann NY Acad Sci 940: 237-246, 2001. (Pubitemid 32623397)
44. Wiley KE, Davenport AP. CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators. Br J Pharmacol 143: 508-514, 2004.
45. Yamazaki T, Waki H, Kohsaka A, Nakamura T, Cui H, Yukawa K, Maeda M. Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure. Auton Neurosci 142: 51-54, 2008.
46. Yang LZ, Kockskamper J, Heinzel FR, Hauber M, Walther S, Spiess J, Pieske B. Urocortin II enhances contractility in rabbit ventricular myocytes via CRF2 receptor-mediated stimulation of protein kinase A. Cardiovasc Res 69: 402-411, 2006.