Cardiovascular responses to microinjections of urocortins into the NTS: Role of inotropic glutamate receptors

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 6, 2009, Pages

  Nakamura, Takeshi ^a   Sapru, Hreday N ^a,b  

^a New Jersey Medical School   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Blood pressure; Corticotrophin releasing factor receptor antagonists; Heart rate; Sympathetic nerve activity

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; URETHAN; UROCORTIN I; UROCORTIN III;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; MICROINJECTION; NERVE CONDUCTION; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SOLITARY TRACT NUCLEUS; SYMPATHETIC NERVE;

AMPHIBIAN PROTEINS; ANILINE COMPOUNDS; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HEART RATE; MALE; MICROINJECTIONS; PEPTIDE HORMONES; PYRIMIDINES; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, GLUTAMATE; SOLITARY NUCLEUS; SYMPATHETIC NERVOUS SYSTEM; UROCORTINS;

EID: 66949143682     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00191.2009     Document Type: Article

References (22)

1. Bindslev N. A homotropic two-state model and auto-antagonism. BMC Pharmacol 4: 11-22, 2004. (Pubitemid 40177103)
2. Bishop GA, Tian JB, Stanke JJ, Fischer AJ. Evidence for the presence of type 2 corticotropin releasing factor receptor in the rodent cerebellum. J Neurosci Res 84: 1255-1269, 2006. (Pubitemid 44654449)
3. Bittencourt JC, Sawchenko PE. Do centrally administered neuropeptides access cognate receptors? An analysis in the central corticotropin-releasing factor system. J Neurosci 20: 1142-1156, 2000. (Pubitemid 30220471)
4. Chen C, Dagnino R Jr, De Souza EB, Grigoriadis DE, Huang CQ, Kim KI, Liu Z, Moran T, Webb TR, Whitten JP, Xie YF, McCarthy JR. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor 1 receptor antagonists. J Med Chem 39: 4358-4360, 1996. (Pubitemid 26359391)
5. Ciriello J, Hochstenbach SL, Roder S. Central projections of baroreceptor and chemoreceptor afferent fibers in the rat. In: Nucleus of the Solitary Tract, edited by Barraco IRA. Boca Raton, FL: CRC, 1994, p. 35-50.
6. Coste SC, Quintos RF, Stenzel-Poore MP. Corticotropin-releasing hormone-related peptides and receptors: emergent regulators of cardiovascular adaptations to stress. Trends Cardiovasc Med 12: 176-182, 2002. (Pubitemid 34586822)
7. Dautzenberg FM, Hauger RL. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol Sci 23: 71-77, 2002. (Pubitemid 34119328)
8. Dhruva A, Bhatnagar T, Sapru HN. Cardiovascular responses to microinjections of glutamate into the nucleus tractus solitarii of unanesthetized supracollicular decerebrate rats. Brain Res 801: 88-100, 1998. (Pubitemid 28401650)
9. Drolet G, Rivest S. Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo. Peptides 22: 761-767, 2001. (Pubitemid 32397727)
10. Kasamatsu K, Chitravanshi VC, Sapru HN. Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors. Am J Physiol Regul Integr Comp Physiol 287: R715-R728, 2004. (Pubitemid 39280455)
11. Lawrence AJ, Krstew EV, Dautzenberg FM, Ruhmann A. The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Br J Pharmacol 136: 896-904, 2002. (Pubitemid 34836864)
12. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci USA 98: 7570-7575, 2001. (Pubitemid 32567989)
13. Nakamura T, Kawabe K, Sapru HN. Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat. Am J Physiol Heart Circ Physiol 296: H325-H332, 2009.
14. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates (4th Ed.). New York: Academic, 1986.
15. Perrin MH, Vale WW. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci 885: 312-328, 1999.
16. Sapru HN. Carotid chemoreflex: neural pathways and transmitters. In: Frontiers in Arterial Chemoreception, edited by Zapata P, Eyzaguirre C, Torrance RW. New York: Plenum, 1996, p. 357-364. (Pubitemid 27074009)
17. Sapru HN. Glutamate circuits in selected medullo-spinal areas regulating cardiovascular function. Clin Exp Pharmacol Physiol 29: 491-496, 2002. (Pubitemid 34535374)
18. Sapru HN, Gonzalez ER, Krieger AJ. Greater splanchnic nerve activity in the rat. Brain Res Bull 8: 267-272, 1982. (Pubitemid 12066423)
19. Talman WT, Granata AR, Reis DJ. Glutamatergic mechanisms in the nucleus tractus solitarius in blood pressure control. Fed Proc 43: 39-44, 1984. (Pubitemid 14175713)
20. Van Pett K, Viau V, Bittencourt JC, Chan RKW, Li HY, Arias C, Prins GS, Perrin M, Vale W, Sawchenko PE. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428: 191-212, 2000.
21. Wang B, You ZB, Rice KC, Wise RA. Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl) 193: 283-294, 2007. (Pubitemid 47025028)
22. Yamazaki T, Waki H, Kohsaka A, Nakamura T, Cui H, Yukawa K, Maeda M. Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure. Auton Neurosci 142: 51-54, 2008.