-
1
-
-
48549101937
-
Analysis of common substructures of metabolic compounds within the different organism groups
-
Muto, A., Hattori, M. and Kanehisa, M. (2007) Analysis of common substructures of metabolic compounds within the different organism groups. Genome Inform., 18, 299-307.
-
(2007)
Genome Inform.
, vol.18
, pp. 299-307
-
-
Muto, A.1
Hattori, M.2
Kanehisa, M.3
-
2
-
-
75549089768
-
The decreased number of new drug approvals (NDAs) has been a topic of considerable debate over the past decade
-
Enna, S.J. and Williams, M. (2009) The decreased number of new drug approvals (NDAs) has been a topic of considerable debate over the past decade. Preface. Adv. Pharmacol., 57, xi-ii.
-
(2009)
Preface. Adv. Pharmacol.
, vol.57
-
-
Enna, S.J.1
Williams, M.2
-
3
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I. and Landis, J. (2004) Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov., 3, 711-715.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
4
-
-
0030886937
-
Managing the drug discovery/development interface
-
Kennedy, T. (1997) Managing the drug discovery/development interface. Drug Discov. Today, 2, 436-444.
-
(1997)
Drug Discov. Today
, vol.2
, pp. 436-444
-
-
Kennedy, T.1
-
5
-
-
43949145741
-
Computational analysis of ligand relationships within target families
-
Bajorath, J. (2008) Computational analysis of ligand relationships within target families. Curr. Opin. Chem. Biol., 12, 352-358.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 352-358
-
-
Bajorath, J.1
-
6
-
-
70349914727
-
PubChem as a source of polypharmacology
-
Chen, B., Wild, D. and Guha, R. (2009) PubChem as a source of polypharmacology. J. Chem. Inf. Model., 49, 2044-2055.
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 2044-2055
-
-
Chen, B.1
Wild, D.2
Guha, R.3
-
7
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser, M.J., Setola, V., Irwin, J.J., Laggner, C., Abbas, A.I., Hufeisen, S.J., Jensen, N.H., Kuijer, M.B., Matos, R.C., Tran, T.B. et al. (2009) Predicting new molecular targets for known drugs. Nature, 462, 175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
Jensen, N.H.7
Kuijer, M.B.8
Matos, R.C.9
Tran, T.B.10
-
8
-
-
41149096945
-
Large-scale prediction of drug-target relationships
-
Kuhn, M., Campillos, M., Gonzalez, P., Jensen, L.J. and Bork, P. (2008) Large-scale prediction of drug-target relationships. FEBS Lett., 582, 1283-1290.
-
(2008)
FEBS Lett.
, vol.582
, pp. 1283-1290
-
-
Kuhn, M.1
Campillos, M.2
Gonzalez, P.3
Jensen, L.J.4
Bork, P.5
-
9
-
-
33847381100
-
A decade of fragment-based drug design: Strategic advances and lessons learned
-
Hajduk, P.J. and Greer, J. (2007) A decade of fragment-based drug design: Strategic advances and lessons learned. Nat. Rev. Drug Discov., 6, 211-219.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
10
-
-
33845736461
-
Drugs in other drugs: A new look at drugs as fragments
-
Siegel, M.G. and Vieth, M. (2007) Drugs in other drugs: A new look at drugs as fragments. Drug Discov. Today, 12, 71-79.
-
(2007)
Drug Discov. Today
, vol.12
, pp. 71-79
-
-
Siegel, M.G.1
Vieth, M.2
-
11
-
-
45249119321
-
Functional group and substructure searching as a tool in metabolomics
-
Kotera, M., McDonald, A.G., Boyce, S. and Tipton, K.F. (2008) Functional group and substructure searching as a tool in metabolomics. PLoS One, 3, e1537.
-
(2008)
PLoS One
, vol.3
-
-
Kotera, M.1
McDonald, A.G.2
Boyce, S.3
Tipton, K.F.4
-
12
-
-
85052722223
-
-
Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council of The National Academies. The National Academies Press, Washington, DC
-
Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council of The National Academies. (2007) Toxicity Testing in the 21st Century: A Vision and A Strategy. The National Academies Press, Washington, DC.
-
(2007)
Toxicity Testing in the 21st Century: A Vision and A Strategy
-
-
-
13
-
-
0033954256
-
The protein Data Bank
-
Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N. and Bourne, P.E. (2000) The Protein Data Bank. Nucleic Acids Res., 28, 235-242.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
Weissig, H.6
Shindyalov, I.N.7
Bourne, P.E.8
-
14
-
-
0033977962
-
SCOP: A structural classification of proteins database
-
Lo Conte, L., Ailey, B., Hubbard, T.J., Brenner, S.E., Murzin, A.G. and Chothia, C. (2000) SCOP: A structural classification of proteins database. Nucleic Acids Res., 28, 257-259.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 257-259
-
-
Lo Conte, L.1
Ailey, B.2
Hubbard, T.J.3
Brenner, S.E.4
Murzin, A.G.5
Chothia, C.6
-
15
-
-
0037805576
-
The KEGG database
-
discussion 101-103, 119-128, 244-152
-
Kanehisa, M. (2002) The KEGG database. Novartis Found. Symp., 247, 91-101; discussion 101-103, 119-128, 244-152.
-
(2002)
Novartis Found. Symp.
, vol.247
, pp. 91-101
-
-
Kanehisa, M.1
-
16
-
-
58149194622
-
SuperToxic: A comprehensive database of toxic compounds
-
Schmidt, U., Struck, S., Gruening, B., Hossbach, J., Jaeger, I.S., Parol, R., Lindequist, U., Teuscher, E. and Preissner, R. (2009) SuperToxic: A comprehensive database of toxic compounds. Nucleic Acids Res., 37, D295-D299.
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Schmidt, U.1
Struck, S.2
Gruening, B.3
Hossbach, J.4
Jaeger, I.S.5
Parol, R.6
Lindequist, U.7
Teuscher, E.8
Preissner, R.9
-
17
-
-
75549090213
-
KEGG for representation and analysis of molecular networks involving diseases and drugs
-
Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M. and Hirakawa, M. (2010) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res., 38, D355-D360.
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Kanehisa, M.1
Goto, S.2
Furumichi, M.3
Tanabe, M.4
Hirakawa, M.5
-
18
-
-
38549151817
-
DrugBank: A knowledgebase for drugs, drug actions and drug targets
-
Wishart, D.S., Knox, C., Guo, A.C., Cheng, D., Shrivastava, S., Tzur, D., Gautam, B. and Hassanali, M. (2008) DrugBank: A knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res., 36, D901-D906.
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastava, S.5
Tzur, D.6
Gautam, B.7
Hassanali, M.8
-
19
-
-
0032058905
-
RECAP - retrosynthetic combinatorial analysis procedure: A powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry
-
Lewell, X.Q., Judd, D.B., Watson, S.P. and Hann, M.M. (1998) RECAP - retrosynthetic combinatorial analysis procedure: A powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry. J. Chem. Inf. Comput. Sci., 38, 511-522.
-
(1998)
J. Chem. Inf. Comput. Sci.
, vol.38
, pp. 511-522
-
-
Lewell, X.Q.1
Judd, D.B.2
Watson, S.P.3
Hann, M.M.4
-
20
-
-
0141726877
-
A 'rule of three' for fragment-based lead discovery?
-
Congreve, M., Carr, R., Murray, C. and Jhoti, H. (2003) A 'rule of three' for fragment-based lead discovery? Drug Discov. Today, 8, 876-877.
-
(2003)
Drug Discov Today
, vol.8
, pp. 876-877
-
-
Congreve, M.1
Carr, R.2
Murray, C.3
Jhoti, H.4
-
22
-
-
0037252194
-
Chris Lipinski discusses life and chemistry after the rule of five
-
Lipinski, C.A. (2003) Chris Lipinski discusses life and chemistry after the Rule of Five. Drug Discov. Today, 8, 12-16.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 12-16
-
-
Lipinski, C.A.1
-
23
-
-
9344248368
-
Prednimustine, mitoxantrone (PmM) vs cyclophosphamide, vincristine, prednisone (COP) for the treatment of advanced low-grade non-Hodgkin's lymphoma
-
German Low-Grade Lymphoma Study Group
-
Unterhalt, M., Herrmann, R., Tiemann, M., Parwaresch, R., Stein, H., Trumper, L., Nahler, M., Reuss-Borst, M., Tirier, C., Neubauer, A. et al. (1996) Prednimustine, mitoxantrone (PmM) vs cyclophosphamide, vincristine, prednisone (COP) for the treatment of advanced low-grade non-Hodgkin's lymphoma. German Low-Grade Lymphoma Study Group. Leukemia, 10, 836-843.
-
(1996)
Leukemia
, vol.10
, pp. 836-843
-
-
Unterhalt, M.1
Herrmann, R.2
Tiemann, M.3
Parwaresch, R.4
Stein, H.5
Trumper, L.6
Nahler, M.7
Reuss-Borst, M.8
Tirier, C.9
Neubauer, A.10
-
24
-
-
50549218745
-
Aryl-2-Halogenoalkylarylamines. Xxi. The design of agents to exploit differences in cellular oxidation-reduction potentials
-
Ross, W.C. (1964) Aryl-2-Halogenoalkylarylamines. Xxi. The design of agents to exploit differences in cellular oxidation-reduction potentials. Biochem. Pharmacol., 13, 969-982.
-
(1964)
Biochem. Pharmacol.
, vol.13
, pp. 969-982
-
-
Ross, W.C.1
|