A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 874-878

  Bu, Yanyan ^a   Shi, Tao ^a   Meng, Minghui ^a   Kong, Guiping ^a   Tian, Yingpu ^a   Chen, Quancheng ^a   Yao, Xinsheng ^a,b   Feng, Gensheng ^a,c   Cheng, Haifeng ^a   Lu, Zhongxian ^a  

^a XIAMEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diabetes; Oleanolic acid; Screening system; Shp2 enhancer

Indexed keywords

ANTIDIABETIC AGENT; ANTIOBESITY AGENT; CHLOROFORM; FORSYTHIA EXTRACT; FORSYTHIA SUSPENSA EXTRACT; GLUCOSE; METFORMIN; OLEANOLIC ACID; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHINESE HERB; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; DRUG TARGETING; ENZYME ACTIVITY; FORSYTHIA; FORSYTHIA SUSPENSA; GLUCOSE BLOOD LEVEL; HIGH THROUGHPUT SCREENING; LOW DRUG DOSE; MOLECULAR MODEL; MOUSE; NONHUMAN; SOLVENT EXTRACTION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DRUGS, CHINESE HERBAL; FORSYTHIA; HUMANS; HYPOGLYCEMIC AGENTS; MICE; OBESITY; OLEANOLIC ACID; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11;

EID: 78651256729     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.049     Document Type: Article

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