Relationship between endothelial cell protein c receptor gene 6936a/g polymorphisms and deep venous thrombosis

Chinese Medical Journal

Volumn 124, Issue 1, 2011, Pages 72-75

  Chen, Xu Dong ^a   Tian, Lu ^a   Li, Ming ^a   Jin, Wei ^a   Zhang, Hong Kun ^a   Zheng, Cheng Fei ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Deep venous thrombosis; Endothelial cell protein c receptor; Polymorphisms

Indexed keywords

ALANINE; ENDOTHELIAL PROTEIN C RECEPTOR; GLYCINE;

ADULT; ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DNA EXTRACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION;

BLOOD COAGULATION FACTORS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; VENOUS THROMBOSIS;

EID: 78651243338     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.01.014     Document Type: Article

References (14)

1. Pestana CI, Torres A, Blanco S, Rojas MJ, Méndez C, López JL, et al. Factor V Leiden and the risk of venous thrombosis, myocardial infarction, and stroke: a case-control study in Venezuela. Genet Test Mol Biomarkers 2009; 13: 537-542.
2. Franco RF, Reitsma PH. Genetic risk factors for venous thrombosis. Human Genet 2001; 109: 369-384.
3. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222-1231.
4. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A 1996; 93: 1021-1026.
5. Centelles MN, Puy C, López-Sagaseta J, Fukudome K, Montes R, Hermida J. Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivo. Thromb Haemost 2010; 103: 1239-1244.
6. Yamagishi K, Cushman M, Heckbert SR, Tsai MY, Folsom AR. Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study. Br J Haematol 2009; 145: 221-226.
7. Saposnik B, Reny JL, Gausem P, Emmerich J, Aiach M, Gandrille S. A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood 2004; 103: 1311-1318.
8. Medina P, Navarro S, Estellés A, Vayá A, Woodhams B, Mira Y, et al. Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk. Thromb Haemost 2004; 91: 905-911.
9. Uitte de Willige S, van Marion V, Rosendaal FR, Vos HL, de Visser MC, Bertina RM. Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis. Thromb Haemost 2004; 2: 1305-1310.
10. Villoutreix BO, Blom AM, Dahlback B. Structural prediction and analysis of endothelial cell protein C/activated protein C receptor. Protein Eng 1999; 12: 833-840.
11. Qu D, Wang Y, Song Y, Esmon NL, Esmon CT. The Ser219→Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype. Thromb Haemost 2006; 4: 229-235.
12. Stearns-Kurosawa DJ, Swindle K, D'Angelo A, Della Valle P, Fattorini A, Caron N, et al. Plasma levels of endothelial protein C receptor respond to anticoagulant treatment. Blood 2002; 99: 526-530.
13. Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 2000; 95: 1687-1693.
14. Fukudome K, Esmon CT. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-26491.