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Volumn 117, Issue 11, 2010, Pages 1279-1286

Levetiracetam for levodopa-induced dyskinesia in Parkinson's disease: A randomized, double-blind, placebo-controlled trial

Author keywords

Antidyskinetic effects; Double blind randomized clinical trial; Levetiracetam; Levodopa induced dyskinesia; Parkinson's disease

Indexed keywords

ETIRACETAM; LEVODOPA; PLACEBO;

EID: 78651241450     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-010-0472-x     Document Type: Article
Times cited : (41)

References (49)
  • 2
    • 22844442888 scopus 로고    scopus 로고
    • Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome
    • DOI 10.1002/mds.20385
    • Y Awaad AM Michon S Minarik 2005 Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome Mov Disord 20 6 714 718 10.1002/mds.20385 10.1002/mds.20385 15704204 (Pubitemid 41056938)
    • (2005) Movement Disorders , vol.20 , Issue.6 , pp. 714-718
    • Awaad, Y.1    Michon, A.M.2    Minarik, S.3
  • 3
    • 1642538376 scopus 로고    scopus 로고
    • Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque
    • DOI 10.1016/j.ejphar.2003.11.065
    • E Bezard MP Hill AR Crossman JM Brotchie A Michel R Grimee H Klitgaard 2004 Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque Eur J Pharmacol 485 1-3 159 164 S0014299903027365 1:CAS:528:DC%2BD2cXnvVyitQ%3D%3D 10.1016/j.ejphar.2003.11.065 14757136 (Pubitemid 38134410)
    • (2004) European Journal of Pharmacology , vol.485 , Issue.1-3 , pp. 159-164
    • Bezard, E.1    Hill, M.P.2    Crossman, A.R.3    Brotchie, J.M.4    Michel, A.5    Grimee, R.6    Klitgaard, H.7
  • 4
    • 0032849293 scopus 로고    scopus 로고
    • German version of the Epworth Sleepiness Scale
    • DOI 10.1159/000029408
    • KE Bloch OD Schoch JN Zhang EW Russi 1999 German version of the Epworth sleepiness scale Respiration 66 5 440 447 1:STN:280:DyaK1Mvksl2qtQ%3D%3D 10.1159/000029408 10516541 (Pubitemid 29431578)
    • (1999) Respiration , vol.66 , Issue.5 , pp. 440-447
    • Bloch, K.E.1    Schoch, O.D.2    Zhang, J.N.3    Russi, E.W.4
  • 5
    • 0035104574 scopus 로고    scopus 로고
    • Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey
    • 1:STN:280:DC%2BD3M7ps1ChtA%3D%3D 10.1093/brain/124.3.546 11222455
    • T Boraud E Bezard B Bioulac CE Gross 2001 Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey Brain 124 Pt 3 546 557 1:STN:280:DC%2BD3M7ps1ChtA%3D%3D 10.1093/brain/124.3.546 11222455
    • (2001) Brain , vol.124 , Issue.PART 3 , pp. 546-557
    • Boraud, T.1    Bezard, E.2    Bioulac, B.3    Gross, C.E.4
  • 6
    • 0033677879 scopus 로고    scopus 로고
    • Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism
    • 1:CAS:528:DC%2BD3cXotVGrtLY%3D 10.1016/S1471-1931(00)00018-5 11052225
    • TN Chase JD Oh 2000 Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism Trends Neurosci 23 10 Suppl S86 S91 1:CAS:528:DC%2BD3cXotVGrtLY%3D 10.1016/S1471-1931(00)00018-5 11052225
    • (2000) Trends Neurosci , vol.23 , Issue.10 SUPPL.
    • Chase, T.N.1    Oh, J.D.2
  • 7
    • 0031923068 scopus 로고    scopus 로고
    • Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease
    • 1:STN:280:DyaK1c3lvVKitw%3D%3D 10.1136/jnnp.64.5.573 9598668
    • A Colzi K Turner AJ Lees 1998 Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease J Neurol Neurosurg Psychiatry 64 5 573 576 1:STN:280:DyaK1c3lvVKitw%3D%3D 10.1136/jnnp.64.5.573 9598668
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , Issue.5 , pp. 573-576
    • Colzi, A.1    Turner, K.2    Lees, A.J.3
  • 8
    • 0037713995 scopus 로고    scopus 로고
    • High-dose ropinirole in advanced Parkinson's disease with severe dyskinesias
    • DOI 10.1097/00002826-200305000-00008
    • S Cristina R Zangaglia F Mancini E Martignoni G Nappi C Pacchetti 2003 High-dose ropinirole in advanced Parkinson's disease with severe dyskinesias Clin Neuropharmacol 26 3 146 150 1:CAS:528:DC%2BD3sXktlyrsL4%3D 10.1097/00002826-200305000-00008 12782917 (Pubitemid 36676293)
    • (2003) Clinical Neuropharmacology , vol.26 , Issue.3 , pp. 146-150
    • Cristina, S.1    Zangaglia, R.2    Mancini, F.3    Martignoni, E.4    Nappi, G.5    Pacchetti, C.6
  • 9
    • 0033428823 scopus 로고    scopus 로고
    • Core Assessment Program for Surgical Interventional Therapies in Parkinson's disease (CAPSIT-PD)
    • DOI 10.1002/1531-8257(199907)14:4<572::AID-MDS1005>3.0.CO;2-C
    • GL Defer H Widner RM Marie P Remy M Levivier 1999 Core assessment program for surgical interventional therapies in Parkinson's disease (capsit-pd) Mov Disord 14 4 572 584 1:STN:280:DyaK1MzmtFyntA%3D%3D 10.1002/1531-8257(199907)14: 4<572::AID-MDS1005>3.0.CO;2-C 10435493 (Pubitemid 30011449)
    • (1999) Movement Disorders , vol.14 , Issue.4 , pp. 572-584
    • Defer, G.-L.1    Widner, H.2    Marie, R.-M.3    Remy, P.4    Levivier, M.5
  • 10
    • 1042299831 scopus 로고    scopus 로고
    • Clozapine improves dyskinesias in Parkinson disease: A double-blind, placebo-controlled study
    • 1:CAS:528:DC%2BD2cXlvFWmsw%3D%3D 14872017
    • F Durif B Debilly M Galitzky D Morand F Viallet M Borg S Thobois E Broussolle O Rascol 2004 Clozapine improves dyskinesias in Parkinson disease: a double-blind, placebo-controlled study Neurology 62 3 381 388 1:CAS:528:DC%2BD2cXlvFWmsw%3D%3D 14872017
    • (2004) Neurology , vol.62 , Issue.3 , pp. 381-388
    • Durif, F.1    Debilly, B.2    Galitzky, M.3    Morand, D.4    Viallet, F.5    Borg, M.6    Thobois, S.7    Broussolle, E.8    Rascol, O.9
  • 12
    • 34548030225 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias
    • doi:10.1002/mds.21475(quiz1523)
    • Fabbrini G, Brotchie JM, Grandas F, Nomoto M, Goetz CG (2007) Levodopa-induced dyskinesias. Mov Disord 22(10):1379-1389. doi: 10.1002/mds.21475 (quiz 1523)
    • (2007) Mov Disord , vol.22 , Issue.10 , pp. 1379-1389
    • Fabbrini, G.1    Brotchie, J.M.2    Grandas, F.3    Nomoto, M.4    Goetz, C.G.5
  • 13
    • 0000224448 scopus 로고
    • The unified Parkinson's disease rating scale
    • Committee UD Fahn S, Marsden CD, Calne DB (eds) Macmillan Healthcare Information, Florham Park 293-304
    • Fahn S, Elton RL, Committee UD (1987) The unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Calne DB (eds) Recent developments in Parkinson's disease, vol 2. Macmillan Healthcare Information, Florham Park, pp 153-163, 293-304
    • (1987) Recent Developments in Parkinson's Disease , vol.2 , pp. 153-163
    • Fahn, S.1    Elton, R.L.2
  • 14
    • 33847757879 scopus 로고    scopus 로고
    • Sarizotan as a treatment for dyskinesias in Parkinson's disease: A double-blind placebo-controlled trial
    • DOI 10.1002/mds.21226
    • CG Goetz P Damier C Hicking E Laska T Muller CW Olanow O Rascol H Russ 2007 Sarizotan as a treatment for dyskinesias in Parkinson's disease: a double-blind placebo-controlled trial Mov Disord 22 2 179 186 10.1002/mds.21226 10.1002/mds.21226 17094088 (Pubitemid 46374758)
    • (2007) Movement Disorders , vol.22 , Issue.2 , pp. 179-186
    • Goetz, C.G.1    Damier, P.2    Hicking, C.3    Laska, E.4    Muller, T.5    Olanow, C.W.6    Rascol, O.7    Russ, H.8
  • 15
    • 0027384928 scopus 로고
    • Effect of nondopaminergic drugs on l-dopa-induced dyskinesias in MPTP-treated monkeys
    • 1:STN:280:DyaK2c%2Fjs1yltg%3D%3D 10.1097/00002826-199310000-00004 8106150
    • B Gomez-Mancilla PJ Bedard 1993 Effect of nondopaminergic drugs on l-dopa-induced dyskinesias in MPTP-treated monkeys Clin Neuropharmacol 16 5 418 427 1:STN:280:DyaK2c%2Fjs1yltg%3D%3D 10.1097/00002826-199310000-00004 8106150
    • (1993) Clin Neuropharmacol , vol.16 , Issue.5 , pp. 418-427
    • Gomez-Mancilla, B.1    Bedard, P.J.2
  • 16
    • 56949101467 scopus 로고    scopus 로고
    • Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster
    • S0014-2999(08)01098-4 1:CAS:528:DC%2BD1cXhsVKrsbvE 10.1016/j.ejphar.2008. 10.048 19014930
    • M Hamann SE Sander A Richter 2008 Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster Eur J Pharmacol 601 1-3 99 102 S0014-2999(08)01098-4 1:CAS:528:DC%2BD1cXhsVKrsbvE 10.1016/j.ejphar.2008.10.048 19014930
    • (2008) Eur J Pharmacol , vol.601 , Issue.13 , pp. 99-102
    • Hamann, M.1    Sander, S.E.2    Richter, A.3
  • 17
    • 0037107182 scopus 로고    scopus 로고
    • Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of parkinsonism
    • 22/18/7850 1:CAS:528:DC%2BD38Xnt12lt70%3D 12223537
    • G Heimer I Bar-Gad JA Goldberg H Bergman 2002 Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of parkinsonism J Neurosci 22 18 7850 7855 22/18/7850 1:CAS:528:DC%2BD38Xnt12lt70%3D 12223537
    • (2002) J Neurosci , vol.22 , Issue.18 , pp. 7850-7855
    • Heimer, G.1    Bar-Gad, I.2    Goldberg, J.A.3    Bergman, H.4
  • 18
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases
    • 1:STN:280:DyaK383is1Omsg%3D%3D 10.1136/jnnp.55.3.181 1564476
    • AJ Hughes SE Daniel L Kilford AJ Lees 1992 Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases J Neurol Neurosurg Psychiatry 55 3 181 184 1:STN:280:DyaK383is1Omsg%3D%3D 10.1136/jnnp.55.3.181 1564476
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , Issue.3 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 19
    • 0033398955 scopus 로고    scopus 로고
    • SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release
    • S0896-6273(00)81046-6 1:CAS:528:DC%2BD3cXislaluw%3D%3D 10.1016/S0896-6273(00)81046-6 10624962
    • R Janz Y Goda M Geppert M Missler TC Sudhof 1999 SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release Neuron 24 4 1003 1016 S0896-6273(00)81046-6 1:CAS:528:DC%2BD3cXislaluw%3D%3D 10.1016/S0896-6273(00) 81046-6 10624962
    • (1999) Neuron , vol.24 , Issue.4 , pp. 1003-1016
    • Janz, R.1    Goda, Y.2    Geppert, M.3    Missler, M.4    Sudhof, T.C.5
  • 20
    • 0842309193 scopus 로고    scopus 로고
    • Low dose quetiapine for drug induced dyskinesias in Parkinson's disease: A double blind cross over study
    • 1:STN:280:DC%2BD2c%2Fnt1OrsA%3D%3D 14742609
    • R Katzenschlager AJ Manson A Evans H Watt AJ Lees 2004 Low dose quetiapine for drug induced dyskinesias in Parkinson's disease: a double blind cross over study J Neurol Neurosurg Psychiatry 75 2 295 297 1:STN:280: DC%2BD2c%2Fnt1OrsA%3D%3D 14742609
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , Issue.2 , pp. 295-297
    • Katzenschlager, R.1    Manson, A.J.2    Evans, A.3    Watt, H.4    Lees, A.J.5
  • 21
    • 20144366287 scopus 로고    scopus 로고
    • Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single-dose challenges
    • DOI 10.1002/mds.20276
    • R Katzenschlager A Hughes A Evans AJ Manson M Hoffman L Swinn H Watt K Bhatia N Quinn AJ Lees 2005 Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: a prospective study using single-dose challenges Mov Disord 20 2 151 157 10.1002/mds.20276 10.1002/mds.20276 15390035 (Pubitemid 40361117)
    • (2005) Movement Disorders , vol.20 , Issue.2 , pp. 151-157
    • Katzenschlager, R.1    Hughes, A.2    Evans, A.3    Manson, A.J.4    Hoffmann, M.5    Swinn, L.6    Watt, H.7    Bhatia, K.8    Quinn, N.9    Lees, A.J.10
  • 22
    • 0034864144 scopus 로고    scopus 로고
    • Levetiracetam: The preclinical profile of a new class of antiepileptic drugs?
    • 11564119
    • H Klitgaard 2001 Levetiracetam: the preclinical profile of a new class of antiepileptic drugs? Epilepsia 42 Suppl 4 13 18 11564119
    • (2001) Epilepsia , vol.42 , Issue.SUPPL. 4 , pp. 13-18
    • Klitgaard, H.1
  • 23
    • 18144423079 scopus 로고    scopus 로고
    • Levodopa-dyskinesia incidence by age of Parkinson's disease onset
    • DOI 10.1002/mds.20360
    • N Kumar JA Van Gerpen JH Bower JE Ahlskog 2005 Levodopa-dyskinesia incidence by age of Parkinson's disease onset Mov Disord 20 3 342 344 10.1002/mds.20360 10.1002/mds.20360 15580606 (Pubitemid 40613295)
    • (2005) Movement Disorders , vol.20 , Issue.3 , pp. 342-344
    • Kumar, N.1    Van Gerpen, J.A.2    Bower, J.H.3    Ahlskog, J.E.4
  • 24
    • 0345798144 scopus 로고    scopus 로고
    • Levodopa therapy with entacapone in daily clinical practice: Results of a post-marketing surveillance study
    • DOI 10.1185/030079903125002775
    • A Kupsch T Trottenberg D Bremen 2004 Levodopa therapy with entacapone in daily clinical practice: results of a post-marketing surveillance study Curr Med Res Opin 20 1 115 120 10.1185/030079903125002775 1:CAS:528:DC%2BD2cXht1entrk%3D 10.1185/030079903125002775 14741081 (Pubitemid 38063463)
    • (2004) Current Medical Research and Opinion , vol.20 , Issue.1 , pp. 115-120
    • Kupsch, A.1    Trottenberg, T.2    Bremen, D.3
  • 26
    • 33746405294 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia
    • DOI 10.1097/01.WNF.0000220814.48360.F4, PII 0000282620060500000008
    • KE Lyons R Pahwa 2006 Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia Clin Neuropharmacol 29 3 148 153 10.1097/01.WNF.0000220814.48360.F4 1:CAS:528:DC%2BD28XlsFeisro%3D 10.1097/01.WNF.0000220814.48360.F4 16772814 (Pubitemid 44503893)
    • (2006) Clinical Neuropharmacology , vol.29 , Issue.3 , pp. 148-153
    • Lyons, K.E.1    Pahwa, R.2
  • 27
    • 0034718588 scopus 로고    scopus 로고
    • Low-dose olanzapine for levodopa induced dyskinesias
    • 1:CAS:528:DC%2BD3cXntlygsLc%3D 10993998
    • AJ Manson A Schrag AJ Lees 2000 Low-dose olanzapine for levodopa induced dyskinesias Neurology 55 6 795 799 1:CAS:528:DC%2BD3cXntlygsLc%3D 10993998
    • (2000) Neurology , vol.55 , Issue.6 , pp. 795-799
    • Manson, A.J.1    Schrag, A.2    Lees, A.J.3
  • 28
    • 0033800837 scopus 로고    scopus 로고
    • Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs
    • 10.1006/phrs.2000.0689 1:STN:280:DC%2BD3M%2FovF2rsg%3D%3D 10.1006/phrs.2000.0689 10987984
    • DG Margineanu H Klitgaard 2000 Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs Pharmacol Res 42 4 281 285 10.1006/phrs.2000.0689 1:STN:280:DC%2BD3M%2FovF2rsg%3D%3D 10.1006/phrs.2000.0689 10987984
    • (2000) Pharmacol Res , vol.42 , Issue.4 , pp. 281-285
    • Margineanu, D.G.1    Klitgaard, H.2
  • 29
    • 0021084666 scopus 로고
    • Quantitative assessment of neuroleptic-induced extrapyramidal symptoms: Clinical and nonclinical approaches
    • 1:STN:280:DyaL2c%2FlsFWhsw%3D%3D 10.1097/00002826-198300061-00006 6139165
    • PR May MA Lee RC Bacon 1983 Quantitative assessment of neuroleptic-induced extrapyramidal symptoms: clinical and nonclinical approaches Clin Neuropharmacol 6 Suppl 1 S35 S51 1:STN:280:DyaL2c%2FlsFWhsw%3D%3D 10.1097/00002826-198300061-00006 6139165
    • (1983) Clin Neuropharmacol , vol.61
    • May, P.R.1    Lee, M.A.2    Bacon, R.C.3
  • 30
    • 58149120928 scopus 로고    scopus 로고
    • L-Dopa therapy for Parkinson's disease: Past, present, and future
    • S1353-8020(09)70004-5 10.1016/S1353-8020(09)70004-5 19131039
    • T Nagatsua M Sawadab 2009 l-Dopa therapy for Parkinson's disease: past, present, and future Parkinsonism Relat Disord 15 Suppl 1 S3 S8 S1353-8020(09)70004-5 10.1016/S1353-8020(09)70004-5 19131039
    • (2009) Parkinsonism Relat Disord , vol.151
    • Nagatsua, T.1    Sawadab, M.2
  • 31
    • 0042243494 scopus 로고    scopus 로고
    • Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices
    • 10.1097/01.wnr.0000081866.45938.bf 1:CAS:528:DC%2BD3sXlt1Whtbo%3D 10.1097/00001756-200307010-00017 12824774
    • I Niespodziany H Klitgaard DG Margineanu 2003 Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices Neuroreport 14 9 1273 1276 10.1097/01.wnr.0000081866.45938.bf 1:CAS:528:DC%2BD3sXlt1Whtbo%3D 10.1097/00001756-200307010-00017 12824774
    • (2003) Neuroreport , vol.14 , Issue.9 , pp. 1273-1276
    • Niespodziany, I.1    Klitgaard, H.2    Margineanu, D.G.3
  • 32
    • 33645220364 scopus 로고    scopus 로고
    • Efficacy and safety of high-dose cabergoline in Parkinson's disease
    • 1:CAS:528:DC%2BD28XislKhtrs%3D 10.1111/j.1600-0404.2005.00514.x 16367894
    • P Odin C Oehlwein A Storch U Polzer G Werner R Renner M Shing A Ludolph P Schuler 2006 Efficacy and safety of high-dose cabergoline in Parkinson's disease Acta Neurol Scand 113 1 18 24 1:CAS:528:DC%2BD28XislKhtrs%3D 10.1111/j.1600-0404.2005.00514.x 16367894
    • (2006) Acta Neurol Scand , vol.113 , Issue.1 , pp. 18-24
    • Odin, P.1    Oehlwein, C.2    Storch, A.3    Polzer, U.4    Werner, G.5    Renner, R.6    Shing, M.7    Ludolph, A.8    Schuler, P.9
  • 33
    • 0033621925 scopus 로고    scopus 로고
    • Pharmacokinetic profile of levetiracetamtoward ideal characteristics
    • DOI 10.1016/S0163-7258(99)00052-2, PII S0163725899000522
    • PN Patsalos 2000 Pharmacokinetic profile of levetiracetam: toward ideal characteristics Pharmacol Ther 85 2 77 85 S0163-7258(99)00052-2 1:CAS:528:DC%2BD3cXosFSnsA%3D%3D 10.1016/S0163-7258(99)00052-2 10722121 (Pubitemid 30069478)
    • (2000) Pharmacology and Therapeutics , vol.85 , Issue.2 , pp. 77-85
    • Patsalos, P.N.1
  • 34
    • 4344639324 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of levetiracetam
    • DOI 10.2165/00003088-200443110-00002
    • PN Patsalos 2004 Clinical pharmacokinetics of levetiracetam Clin Pharmacokinet 43 11 707 724 1:CAS:528:DC%2BD2cXnvVGms7c%3D 10.2165/00003088- 200443110-00002 15301575 (Pubitemid 39159001)
    • (2004) Clinical Pharmacokinetics , vol.43 , Issue.11 , pp. 707-724
    • Patsalos, P.N.1
  • 35
    • 29244453213 scopus 로고    scopus 로고
    • Effects of dyskinesias in Parkinson's disease on quality of life and health-related costs: A prospective European study
    • DOI 10.1111/j.1468-1331.2005.01096.x
    • M Pechevis CE Clarke P Vieregge B Khoshnood C Deschaseaux-Voinet G Berdeaux M Ziegler 2005 Effects of dyskinesias in Parkinson's disease on quality of life and health-related costs: a prospective European study Eur J Neurol 12 12 956 963 1:STN:280:DC%2BD2MnksVGktw%3D%3D 10.1111/j.1468-1331.2005.01096.x 16324089 (Pubitemid 41820050)
    • (2005) European Journal of Neurology , vol.12 , Issue.12 , pp. 956-963
    • Pechevis, M.1    Clarke, C.E.2    Vieregge, P.3    Khoshnood, B.4    Deschaseaux-Voinet, C.5    Berdeaux, G.6    Ziegler, M.7
  • 36
    • 0036113588 scopus 로고    scopus 로고
    • Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response: A 6-month randomized placebo controlled double blind study in Germany and Austria (Celomen study)
    • DOI 10.1034/j.1600-0404.2002.1o174.x
    • WH Poewe G Deuschl A Gordin ER Kultalahti M Leinonen 2002 Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response: a 6-month randomized placebo-controlled double-blind study in Germany and Austria (Celomen study) Acta Neurol Scand 105 4 245 255 1:CAS:528: DC%2BD38XjvFGgs70%3D 10.1034/j.1600-0404.2002.1o174.x 11939936 (Pubitemid 34407226)
    • (2002) Acta Neurologica Scandinavica , vol.105 , Issue.4 , pp. 245-255
    • Poewe, W.H.1    Deuschl, G.2    Gordin, A.3    Kultalahti, E.-R.4    Leinonen, M.5
  • 37
    • 38049095254 scopus 로고    scopus 로고
    • Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy
    • 1:CAS:528:DC%2BD1cXitVOgt7o%3D 18183537
    • JR Pollard 2008 Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy Curr Opin Investig Drugs 9 1 101 107 1:CAS:528: DC%2BD1cXitVOgt7o%3D 18183537
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.1 , pp. 101-107
    • Pollard, J.R.1
  • 38
    • 19344378940 scopus 로고    scopus 로고
    • Entacapone in the treatment of Parkinson's disease
    • DOI 10.1016/S1474-4422(05)70098-3, PII S1474442205700983
    • A Schrag 2005 Entacapone in the treatment of Parkinson's disease Lancet Neurol 4 6 366 370 S1474-4422(05)70098-3 1:CAS:528:DC%2BD2MXls1eis7c%3D 10.1016/S1474-4422(05)70098-3 15907741 (Pubitemid 40720033)
    • (2005) Lancet Neurology , vol.4 , Issue.6 , pp. 366-370
    • Schrag, A.1
  • 39
    • 71849108352 scopus 로고    scopus 로고
    • The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease
    • doi:S1353-8020(09)70784-9
    • Stocchi F (2009) The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease. Parkinsonism Relat Disord 15(Suppl 3):S68-S71. doi: S1353-8020(09)70784-9
    • (2009) Parkinsonism Relat Disord , vol.15 , Issue.SUPPL. 3
    • Stocchi, F.1
  • 40
    • 53149141398 scopus 로고    scopus 로고
    • Treatment of levodopa-induced motor complications
    • doi:10.1002/mds.22052
    • Stocchi F, Tagliati M, Olanow CW (2008) Treatment of levodopa-induced motor complications. Mov Disord 23(Suppl 3):S599-S612. doi: 10.1002/mds.22052
    • (2008) Mov Disord , vol.23 , Issue.SUPPL. 3
    • Stocchi, F.1    Tagliati, M.2    Olanow, C.W.3
  • 41
    • 24944486368 scopus 로고    scopus 로고
    • High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias
    • DOI 10.1016/j.parkreldis.2005.03.005, PII S1353802005000829
    • A Storch C Trenkwalder C Oehlwein J Winkelmann U Polzer HP Hundemer J Schwarz 2005 High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias Parkinsonism Relat Disord 11 6 393 398 S1353-8020(05)00082-9 10.1016/j.parkreldis.2005.03.005 15993640 (Pubitemid 41317808)
    • (2005) Parkinsonism and Related Disorders , vol.11 , Issue.6 , pp. 393-398
    • Storch, A.1    Trenkwalder, C.2    Oehlwein, C.3    Winkelmann, J.4    Polzer, U.5    Hundemer, H.-P.6    Schwarz, J.7
  • 42
    • 22144443869 scopus 로고    scopus 로고
    • The effect of levetiracetam on levodopa induced dyskinesia in patients with Parkinson's disease [1]
    • DOI 10.1016/j.parkreldis.2004.11.003, PII S1353802004001968
    • B Tousi T Subramanian 2005 The effect of levetiracetam on levodopa induced dyskinesia in patients with Parkinson's disease Parkinsonism Relat Disord 11 5 333 334 S1353-8020(04)00196-8 10.1016/j.parkreldis.2004.11.003 15949966 (Pubitemid 40982511)
    • (2005) Parkinsonism and Related Disorders , vol.11 , Issue.5 , pp. 333-334
    • Tousi, B.1    Subramanian, T.2
  • 43
    • 0345084477 scopus 로고    scopus 로고
    • Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease
    • L Verhagen Metman P Del Dotto R Natte P van den Munckhof TN Chase 1998 Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease Neurology 51 1 203 206 1:STN:280:DyaK1czjslGlsg%3D%3D 9674803 (Pubitemid 28345384)
    • (1998) Neurology , vol.51 , Issue.1 , pp. 203-206
    • Verhagen Metman, L.1    Del Dotto, P.2    Natte, R.3    Van Den Munckhof, P.4    Chase, T.N.5
  • 44
    • 0006647256 scopus 로고    scopus 로고
    • Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease
    • L Verhagen Metman P Del Dotto P van den Munckhof J Fang MM Mouradian TN Chase 1998 Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease Neurology 50 5 1323 1326 1:STN:280:DyaK1c3lsFChsg%3D%3D 9595981 (Pubitemid 28240346)
    • (1998) Neurology , vol.50 , Issue.5 , pp. 1323-1326
    • Verhagen Metman, L.1    Del Dotto, P.2    Van Den Munckhof, P.3    Fang, J.4    Mouradian, M.M.5    Chase, T.N.6
  • 45
    • 0034105157 scopus 로고    scopus 로고
    • Physiology of hypokinetic and hyperkinetic movement disorders: Model for dyskinesia
    • 1:CAS:528:DC%2BD3cXivVOntbg%3D 10762140
    • JL Vitek M Giroux 2000 Physiology of hypokinetic and hyperkinetic movement disorders: model for dyskinesia Ann Neurol 47 4 Suppl 1 S131 S140 1:CAS:528:DC%2BD3cXivVOntbg%3D 10762140
    • (2000) Ann Neurol , vol.47 , Issue.4 SUPPL. 1
    • Vitek, J.L.1    Giroux, M.2
  • 46
    • 2542571133 scopus 로고    scopus 로고
    • Long-term results of bilateral pallidal stimulation in Parkinson's disease
    • DOI 10.1002/ana.20091
    • J Volkmann N Allert J Voges V Sturm A Schnitzler HJ Freund 2004 Long-term results of bilateral pallidal stimulation in Parkinson's disease Ann Neurol 55 6 871 875 10.1002/ana.20091 10.1002/ana.20091 15174022 (Pubitemid 38702583)
    • (2004) Annals of Neurology , vol.55 , Issue.6 , pp. 871-875
    • Volkmann, J.1    Allert, N.2    Voges, J.3    Sturm, V.4    Schnitzler, A.5    Freund, H.-J.6
  • 47
    • 44849130867 scopus 로고    scopus 로고
    • Effects of levetiracetam on tardive dyskinesia: A randomized, double-blind, placebo-controlled study
    • ej07m03338 1:CAS:528:DC%2BD1cXmtFShsbg%3D 10.4088/JCP.v69n0405 18312060
    • SW Woods JR Saksa CB Baker SJ Cohen C Tek 2008 Effects of levetiracetam on tardive dyskinesia: a randomized, double-blind, placebo-controlled study J Clin Psychiatry 69 4 546 554 ej07m03338 1:CAS:528:DC%2BD1cXmtFShsbg%3D 10.4088/JCP.v69n0405 18312060
    • (2008) J Clin Psychiatry , vol.69 , Issue.4 , pp. 546-554
    • Woods, S.W.1    Saksa, J.R.2    Baker, C.B.3    Cohen, S.J.4    Tek, C.5
  • 48
    • 23644462322 scopus 로고    scopus 로고
    • Open-label pilot study of levetiracetam (Keppra) for the treatment of levodopa-induced dyskinesias in Parkinson's disease
    • DOI 10.1002/mds.20563
    • TA Zesiewicz KL Sullivan JL Maldonado WO Tatum RA Hauser 2005 Open-label pilot study of levetiracetam (keppra) for the treatment of levodopa-induced dyskinesias in Parkinson's disease Mov Disord 20 9 1205 1209 10.1002/mds.20563 10.1002/mds.20563 15954135 (Pubitemid 41632212)
    • (2005) Movement Disorders , vol.20 , Issue.9 , pp. 1205-1209
    • Zesiewicz, T.A.1    Sullivan, K.L.2    Maldonado, J.L.3    Tatum, W.O.4    Hauser, R.A.5
  • 49
    • 33845206589 scopus 로고    scopus 로고
    • Open-label pilot study of levetiracetam (Keppra) for the treatment of chorea in Huntington's disease
    • DOI 10.1002/mds.21061
    • TA Zesiewicz KL Sullivan RA Hauser J Sanchez-Ramos 2006 Open-label pilot study of levetiracetam (keppra) for the treatment of chorea in Huntington's disease Mov Disord 21 11 1998 2001 10.1002/mds.21061 10.1002/mds.21061 16941461 (Pubitemid 44848955)
    • (2006) Movement Disorders , vol.21 , Issue.11 , pp. 1998-2001
    • Zesiewicz, T.A.1    Sullivan, K.L.2    Hauser, R.A.3    Sanchez-Ramos, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.