Mitochondrial mode of action of a thymidine-based cisplatin analogue breaks resistance in cancer cells

Chemistry - A European Journal

Volumn 16, Issue 48, 2010, Pages 14498-14505

  Onambele, Liliane A ^a   Koth, Daniel ^b   Czaplewska, Justyna A ^b   Schubert, Ulrich S ^b   Görls, Helmar ^b   Yano, Shigenobu ^c   Obata, Makoto ^d   Gottschaldt, Michael ^b   Prokop, Aram ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^d UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

antitumor agents; apoptosis; drug resistance; nucleosides; platinum

Indexed keywords

AMINO GROUP; ANTI-TUMOR AGENTS; APOPTOSIS; APOPTOSIS PATHWAYS; APOPTOTIC RESPONSE; CANCER CELLS; CASPASE ACTIVATION; CASPASES; CIS-PLATIN; DAUNORUBICIN; DEATH DOMAIN; DOXORUBICIN; DRUG RESISTANCE; ERYTHRO; IN-CELL; IN-VITRO; LEUKEMIA CELLS; LYMPHOMA CELLS; MELANOMA CELLS; METAL CENTERS; MITOCHONDRIAL MEMBRANE POTENTIAL; MODE OF ACTION; NUCLEOSIDES; PALLADIUM COMPLEXES; RESISTANT CELLS; SINGLE CRYSTAL X-RAY STRUCTURES; SPECTROSCOPIC MEASUREMENTS; SYNERGISTIC EFFECT;

BIOMOLECULES; CELL CULTURE; CELL DEATH; CELL MEMBRANES; CRYSTAL STRUCTURE; DISEASES; LIGANDS; MITOCHONDRIA; ONCOLOGY; PALLADIUM; PALLADIUM COMPOUNDS; PLATINUM; SINGLE CRYSTALS; SPECTROSCOPIC ANALYSIS;

PLATINUM COMPOUNDS;

ANTINEOPLASTIC AGENT; CISPLATIN; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; DRUG DERIVATIVE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PALLADIUM; PLATINUM COMPLEX; THYMIDINE; THYMIPLATIN; VINCRISTINE;

APOPTOSIS; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; HUMAN; METABOLISM; MITOCHONDRION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PROTO ONCOGENE; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENES, BCL-2; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; PALLADIUM; THYMIDINE; VINCRISTINE;

EID: 78651230561     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201000785     Document Type: Article

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