Association of SND1 protein to low density lipid droplets in liver steatosis

Journal of Physiology and Biochemistry

Volumn 66, Issue 1, 2010, Pages 73-83

  Garcia Arcos, I ^a   Rueda, Y ^a   Gonzalez Kother P ^a,b   Palacios, L ^a,c   Ochoa, B ^a   Fresnedo, O ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN   (Chile)

^c Progenika Biopharma SA   (Spain)

Author keywords

Hepatic steatosis; Hepatocytes; Lipid droplets; SND P102; SND1

Indexed keywords

FAT DROPLET; NUCLEAR PROTEIN; OLEIC ACID; SND1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FATTY LIVER; FEMALE; GOLGI COMPLEX; LIPID ANALYSIS; LIVER CELL CULTURE; LIVER MICROSOME; LIVER PARENCHYMA; NONHUMAN; PROTEIN LOCALIZATION; RAT; SUCROSE GRADIENT;

ANIMALS; ENDOPLASMIC RETICULUM; FATTY LIVER; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GOLGI APPARATUS; HUMANS; LIPID METABOLISM; LIVER; NUCLEAR PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

MAMMALIA; RATTUS;

EID: 77955097021     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-010-0011-0     Document Type: Article

References (44)

1. Bartz R, Li B, VenablesWH, Zehmer JK, Roth MR, Welti R, Anderson RG, Liu P, Chapman KD (2007) Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res 48:837-847.
2. Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E (2003) Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res 2:69-79.
3. Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, Jiang H, Schwabe RF, Hillman EM, Piantedosi R, Libien J (2008) Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta. doi:10.106/j.bbalip. 2008.11.001.
4. Brasaemle DL, Dolios G, Shapiro L, Wang R (2004) Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem 279:46835-46842.
5. Brito GC, Fachel AA, Vettore AL, Vignal GM, Gimba ERP, Campos FS, Barcinski MA, Verjovski-Almeida S, Reis EM (2008) Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinoma. Mol Carcinog 47:757-767.
6. Broadhurst MK, Lee RS, Hawkins S, Wheeler TT (2005) The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle. Biochim Biophys Acta 1681:126-133.
7. Broadhurst MK, Wheeler TT (2001) The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation. J Endocrinol 171:329-337.
8. Caudy AA, Ketting RF, Hammond SM, Denli AM, Bathoorn AM, Tops BB, Silva JM, Myers MM, Hannon GJ, Plasterk RH (2003) A micrococcal nuclease homologue in RNAi effector complexes. Nature 425:411-414.
9. Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res 5:3135-3144.
10. Dugail I, Hajduch E (2007) A new look at adipocyte lipid droplets: towards a role in the sensing of triacylglycerol stores? Cell Mol Life Sci 64:2452-2458.
11. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509.
12. Fresnedo O, De Heredia ML, Martinez MJ, Cristobal S, Rejas MT, Cuezva JM, Ochoa B (2001) Immunolocalization of a novel cholesteryl ester hydrolase in the endoplasmic reticulum of murine and human hepatocytes. Hepatology 33:662-667.
13. Fujimoto Y, Onoduka J, Homma KJ, Yamaguchi S, Mori M, HigashiY, MakitaM, Kinoshita T, Noda J, Itabe H, Takanoa T (2006) Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of Acyl-CoA synthetase. Biol Pharm Bull 29:2174-2180.
14. Ho J, Kong JWF, Choong LY, Loh MCS, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP (2009) Novel breast cancer metastasis-associated proteins. J Proteome Res 8:583-594.
15. Keenan TW, Winter S, Rackwitz HR, Heid HW (2000) Nuclear coactivator protein p100 is present in endoplasmic reticulum and lipid droplets of milk secreting cells. Biochim Biophys Acta 1523:84-90.
16. Kellner-Weibel G, Hendry-Rinde B, Haynes MP, Adelman S (2001) Evidence that newly synthesized esterified cholesterol is deposited in existing cytoplasmic lipid inclusions. J Lipid Res 42:768-777.
17. Kessler RJ, Fanestil DD (1986) Interference by lipids in the determination of protein using bicinchoninic acid. Anal Biochem 159:138-142.
18. Martin S, Parton RG (2006) Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7:373-378.
19. Miura S, Gan JW, Brzostowski J, Parisi MJ, Schultz CJ, Londos C, Oliver B, Kimmel AR (2002) Functional conservation for lipid storage droplet association among perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem 277:32253-32257.
20. Moore HP, Silver RB, Mottillo EP, Bernlohr DA, Granneman JG (2005) Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J Biol Chem 280:43109-43120.
21. Murphy DJ, Vance J (1999) Mechanisms of lipid-body formation. Trends Biochem Sci 24:109-115.
22. Ontko JA, Perrin LW, Horne LS (1986) Isolation of hepatocellular lipid droplets: the separation of distinct subpopulations. J Lipid Res 27:1097-1103.
23. Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T (2005) Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulumderived membrane. J Cell Sci 118:2601-2611.
24. Palacios L, Ochoa B, Jose Gomez-Lechon M, Vicente CJ, Fresnedo O (2006) Overexpression of SND p102, a rat homologue of p100 coactivator, promotes the secretion of lipoprotein phospholipids in primary hepatocytes. Biochim Biophys Acta 1761:698-708.
25. Paukku K, Yang J, Silvennoinen O (2003) Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5. Mol Endocrinol 17:1805-1814.
26. Rinia HA, Burger KN, Bonn M, Muller M (2008) Quantitative label-free imaging of lipid composition and packing of individual cellular lipid droplets using multiplex CARS microscopy. Biophys J 95:4908-4914.
27. Robenek H, Hofnagel O, Buers I, Robenek MJ, Troyer D, Severs NJ (2006) Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis. J Cell Sci 119:4215-4224.
28. Ruiz JI, Ochoa B (1997) Quantification in the subnanomolar range of phospholipids and neutral lipids by monodimensional thin-layer chromatography and image analysis. J Lipid Res 38:1482-1489.
29. Sakamoto K, Yamasaki Y, Kaneto H, Fujitani Y, Matsuoka T, Yoshioka R, Tagawa T, Matsuhisa M, Kajimoto Y, Hori M (1999) Identification of oxidative stress-regulated genes in rat aortic smooth muscle cells by suppression subtractive hybridization. FEBS Lett 461:47-51.
30. Sami-Subbu R, Choi SB, Wu Y, Wang C, Okita TW (2001) Identification of a cytoskeleton-associated 120 kDa RNAbinding protein in developing rice seeds. Plant Mol Biol 46:79-88.
31. Scadden AD (2005) The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNAand promotes its cleavage. Nat Struct Mol Biol 12:489-496.
32. Shaw N, Zhao M, Cheng C, Xu H, Saarikettu J, Li Y, Da Y, Yao Z, Silvennoinen O, Yang J, Liu ZJ, Wang BC, Rao Z (2007) The multifunctional human p100 protein "hooks" methylated ligands. Nat Struct Mol Biol 14:779-784.
33. Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (1995) The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol Cell Biol 15:4735-4744.
34. Trotter NL (1964) A fine structure study of lipid in mouse liver regenerating after partial hepatectomy. J Cell Biol 21:233-244.
35. Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H (2007) SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis. Cancer Res 67:9568-9576.
36. Umlauf E, Csaszar E, Moertelmaier M, Schuetz GJ, Parton RG, Prohaska R (2004) Association of stomatin with lipid bodies. J Biol Chem 279:23699-23709.
37. Valineva T, Yang J, Palovuori R, Silvennoinen O (2005) The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J Biol Chem 280:14989-14996.
38. Valineva T, Yang J, Silvennoinen O (2006) Characterization of RNA helicase A as component of STAT6-dependent enhanceosome. Nucl Acids Res 34:3938-3946.
39. Waynforth HB, Fleccknell PA (1992) Experimental and surgical technique in the rat. Academic Press.
40. Welte MA (2007) Proteins under new management: lipid droplets deliver. Trends Cell Biol 17:363-369.
41. Wolins NE, Brasaemle DL, Bickel PE (2006) A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett 580:5484-5491.
42. Yang J, Aittomaki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J 21:4950-4958.
43. Yang J, Valineva T, Hong J, Bu T, Yao Z, Jensen ON, Frilander MJ, Silvennoinen O (2007) Transcriptional coactivator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. Nucl Acids Res 35:4485-4494.
44. Zhao CT, Shi KH, Su Y, Liang LY, Yan Y, Postlethwait J, Meng AM (2003) Two variants of zebrafish p100 are expressed during embryogenesis and regulated by nodal signaling. FEBS Lett 543:190-195.