In vitro and in vivo relaxation of urinary bladder smooth muscle by the selective myosin II inhibitor, blebbistatin

BJU International

Volumn 107, Issue 2, 2011, Pages 310-317

  Zhang, Xinhua ^a   Kuppam, Dwaraka Srinivasa R ^a   Melman, Arnold ^a   Disanto, Michael E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

blebbistatin; cross bridge cycling; detrusor overactivity; myosin; smooth muscle contraction

Indexed keywords

BLEBBISTATIN; MYOSIN II;

ANIMAL TISSUE; ARTICLE; BLADDER CAPACITY; BLADDER COMPLIANCE; BLADDER CONTRACTION; BLADDER MUSCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; URINARY FREQUENCY; URINE VOLUME; URODYNAMICS;

ANIMALS; ENDOTHELIN-1; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOSIN TYPE II; PARASYMPATHOLYTICS; RATS; RATS, SPRAGUE-DAWLEY; URINARY BLADDER; URINARY BLADDER, OVERACTIVE;

EID: 78651098381     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2010.09366.x     Document Type: Article

References (33)

1. Colli E, Digesu GA, Olivieri L,. Overactive bladder treatments in early phase clinical trials. Expert Opin Invest Drugs 2007; 16: 999-1007
2. Andersson KE, Arner A,. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 2004; 84: 935-86
3. Brostrom S, Hallas J,. Persistence of antimuscarinic drug use. Eur J Clin Pharmacol 2009; 65: 309-14
4. MacDiarmid SA,. Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached? BJU Int 2007; 99 (Suppl. 3): 8-12
5. Hegde SS, Mammen M, Jasper JR,. Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies. Curr Opin Invest Drugs 2004; 5: 40-9
6. Andersson KE, Chapple CR, Cardozo L, et al. Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence. Curr Opin Urol 2009; 19: 380-94
7. Yoshimura N, Kaiho Y, Miyazato M, et al. Therapeutic receptor targets for lower urinary tract dysfunction. Naunyn Schmiedebergs Arch Pharmacol 2008; 377: 437-48
8. Straight AF, Cheung A, Limouze J, et al. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science 2003; 299: 1743-7
9. Limouze J, Straight AF, Mitchison T, Sellers JR,. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil 2004; 25: 337-41
10. Eddinger TJ, Meer DP, Miner AS, Meehl J, Rovner AS, Ratz PH,. Potent inhibition of arterial smooth muscle tonic contractions by the selective myosin II inhibitor, blebbistatin. J Pharmacol Exp Ther 2007; 320: 865-70
11. Kovacs M, Toth J, Hetenyi C, Malnasi-Csizmadia A, Sellers JR,. Mechanism of blebbistatin inhibition of myosin II. J Biol Chem 2004; 279: 35557-63
12. Rhee AY, Ogut O, Brozovich FV,. Nonmuscle myosin, force maintenance, and the tonic contractile phenotype in smooth muscle. Pflugers Arch 2006; 452: 766-74
13. Zhang XH, Aydin M, Kuppam D, Melman A, Disanto ME,. In vitro and in vivo relaxation of corpus cavernosum smooth muscle by the selective myosin II inhibitor, blebbistatin. J Sex Med 2009; 6: 2661-71
14. Sandhu KS, Chua RG, Zhang X, et al. Regional heterogeneity in expression of the sphingosine-1-phosphate pathway in the female rat lower urinary tract. Am J Obstet Gynecol 2009; 200: 576-7
15. Chua RG, Calenda G, Zhang X, et al. Testosterone regulates erectile function and Vcsa1 expression in the corpora of rats. Mol Cell Endocrinol 2009; 303: 67-73
16. Yamamoto M, Harm SC, Grasser WA, Thiede MA,. Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch. Proc Natl Acad Sci USA 1992; 89: 5326-30
17. Ren J, Wang GJ, Petrovski P, Ren BH, Brown RA,. Influence of hypertension on acetaldehyde-induced vasorelaxation in rat thoracic aorta. Pharmacol Res 2002; 45: 195-9 (Pubitemid 35418361)
18. Malmgren A, Andersson PO, Uvelius B,. Bladder function in rats with short- and long-term diabetes; effects of age and muscarinic blockade. J Urol 1989; 142: 1608-14
19. Suadicani SO, Urban-Maldonado M, Tar MT, Melman A, Spray DC,. Effects of ageing and streptozotocin-induced diabetes on connexin43 and P2 purinoceptor expression in the rat corpora cavernosa and urinary bladder. BJU Int 2009; 103: 1686-93
20. Melman A, Zotova E, Kim M, et al. Longitudinal studies of time-dependent changes in both bladder and erectile function after streptozotocin-induced diabetes in Fischer 344 male rats. BJU Int 2009; 104: 1292-300
21. Biers SM, Reynard JM, Brading AF,. The effects of a new selective beta3-adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder. BJU Int 2006; 98: 1310-4
22. Kelleher CJ, Kreder KJ, Pleil AM, Burgess SM, Reese PR,. Long-term health-related quality of life of patients receiving extended-release tolterodine for overactive bladder. Am J Manag Care 2002; 8: S616-30
23. Kelleher CJ, Reese PR, Pleil AM, Okano GJ,. Health-related quality of life of patients receiving extended-release tolterodine for overactive bladder. Am J Manag Care 2002; 8: S608-15
24. Ekman M, Fagher K, Wede M, Stakeberg K, Arner A,. Decreased phosphatase activity, increased Ca2+ sensitivity, and myosin light chain phosphorylation in urinary bladder smooth muscle of newborn mice. J Gen Physiol 2005; 125: 187-96
25. Lofgren M, Ekblad E, Morano I, Arner A,. Nonmuscle Myosin motor of smooth muscle. J Gen Physiol 2003; 121: 301-10
26. Malmqvist U, Arner A, Uvelius B,. Contractile and cytoskeletal proteins in smooth muscle during hypertrophy and its reversal. Am J Physiol 1991; 260: C1085-93
27. Hashitani H, Brading AF, Suzuki H,. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 2004; 141: 183-93
28. Drake MJ, Hedlund P, Harvey IJ, Pandita RK, Andersson KE, Gillespie JI,. Partial outlet obstruction enhances modular autonomous activity in the isolated rat bladder. J Urol 2003; 170: 276-9
29. Maggi CA, Giuliani S, Patacchini R, et al. Potent contractile activity of endothelin on the human isolated urinary bladder. Br J Pharmacol 1989; 96: 755-7 (Pubitemid 19100026)
30. Saenz TI, de Mueller JD, Las MA, et al. Endothelin in the urinary bladder. I. Synthesis of endothelin-1 by epithelia, muscle and fibroblasts suggests autocrine and paracrine cellular regulation. J Urol 1992; 148: 1290-8
31. Hypolite JA, DiSanto ME, Zheng Y, Chang S, Wein AJ, Chacko S,. Regional variation in myosin isoforms and phosphorylation at the resting tone in urinary bladder smooth muscle. Am J Physiol Cell Physiol 2001; 280: C254-64
32. Lavelle JP, Meyers SA, Ruiz WG, Buffington CA, Zeidel ML, Apodaca G,. Urothelial pathophysiological changes in feline interstitial cystitis: a human model. Am J Physiol Renal Physiol 2000; 278: F540-53
33. Gao X, Buffington CA, Au JL,. Effect of interstitial cystitis on drug absorption from urinary bladder. J Pharmacol Exp Ther 1994; 271: 818-23