메뉴 건너뛰기




Volumn 16, Issue 7, 2007, Pages 999-1007

Overactive bladder treatments in early phase clinical trials

Author keywords

A 278637; KW 7158; NS 8; Overactive bladder; ZD 6169

Indexed keywords

A 251179; A 278637; APREPITANT; BESIPIRDINE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BXL 628; COLECALCIFEROL DERIVATIVE; DIHYDROPYRIDINE DERIVATIVE; ELOCALCITOL; FLURBIPROFEN 4 NITROXYBUTYL ESTER; KIL 769; KUC 7483; KW 7158; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; NEUROKININ 1 RECEPTOR ANTAGONIST; NS 309; NS 8; OXYBUTYNIN; PLACEBO; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; PURINERGIC RECEPTOR BLOCKING AGENT; REC 0545; SEROTONIN 1A ANTAGONIST; SOLABEGRON; SSR 240600; SULFONYLDIHYDROPYRIDINE DERIVATIVE; TA 5538; UNCLASSIFIED DRUG; UNINDEXED DRUG; YM 178; ZD 0947;

EID: 34447542939     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.16.7.999     Document Type: Review
Times cited : (40)

References (40)
  • 1
    • 0026072983 scopus 로고
    • Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro
    • EDWARDS G, HENSHAW M, MILLER M, WESTON AH: Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro. Br. J. Pbarmacol. (1991) 102:679-686.
    • (1991) Br. J. Pbarmacol , vol.102 , pp. 679-686
    • EDWARDS, G.1    HENSHAW, M.2    MILLER, M.3    WESTON, A.H.4
  • 2
    • 0000631336 scopus 로고    scopus 로고
    • Relaxant efficacy of potassium channel openers in rabbit isolated bladder and mesenteric artery
    • BARRAS M, VAN DER GRAF PH, CHRISTOPH P, ITZCHAK A. Relaxant efficacy of potassium channel openers in rabbit isolated bladder and mesenteric artery. Eur. J. Urol. (1996) 30(Suppl. 2):240.
    • (1996) Eur. J. Urol , vol.30 , Issue.SUPPL. 2 , pp. 240
    • BARRAS, M.1    VAN DER GRAF, P.H.2    CHRISTOPH, P.3    ITZCHAK, A.4
  • 3
    • 0026322693 scopus 로고
    • Effects of pinacidil on detrusor instability in men with outlet obstruction
    • HEDLUND H, ANDERSSON K-E, MATTIASSON A: Effects of pinacidil on detrusor instability in men with outlet obstruction. J. Urol. (1991) 146:1345-1347.
    • (1991) J. Urol , vol.146 , pp. 1345-1347
    • HEDLUND, H.1    ANDERSSON, K.-E.2    MATTIASSON, A.3
  • 4
    • 0028968030 scopus 로고
    • The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions
    • KOMERSOVA K, ROGERSON JW, CONWAY EL et al.: The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions. Br. J. Pharmacol. (1995) 39:207-209.
    • (1995) Br. J. Pharmacol , vol.39 , pp. 207-209
    • KOMERSOVA, K.1    ROGERSON, J.W.2    CONWAY, E.L.3
  • 5
    • 34447547731 scopus 로고    scopus 로고
    • MAZZUCCO R: American Urological Association - 96th Annual Meeting. 2-7 June 2001, Anaheim, CA, USA. IDrugs (2001) 4(8):892-895.
    • MAZZUCCO R: American Urological Association - 96th Annual Meeting. 2-7 June 2001, Anaheim, CA, USA. IDrugs (2001) 4(8):892-895.
  • 6
    • 0141731329 scopus 로고    scopus 로고
    • Medicinal Chemistry - XVIIth International Symposium
    • 961-963
    • CONTRAFOURIS Y: Medicinal Chemistry - XVIIth International Symposium. IDrugs (2002) 5(10):961-963.
    • (2002) IDrugs , vol.5 , Issue.10
    • CONTRAFOURIS, Y.1
  • 7
    • 85018672218 scopus 로고    scopus 로고
    • Buckner design and synthesis of aminal-containing ATP-sensitive potassium channel openers for the treatment of bladder overactivity
    • Boston, USA 18, 22 August
    • PEREZ-MEDRANO A, KORT ME, GREGG RJ et al.: Buckner design and synthesis of aminal-containing ATP-sensitive potassium channel openers for the treatment of bladder overactivity. 224th American Chemical Society Meeting, Boston, USA (18 - 22 August 2002).
    • (2002) 224th American Chemical Society Meeting
    • PEREZ-MEDRANO, A.1    KORT, M.E.2    GREGG, R.J.3
  • 8
    • 34447576624 scopus 로고    scopus 로고
    • In vivo anorectic activity of substituted tetrahydro-indeno[1,2-d]thiazols
    • Boston, MA, USA 18, 22 August
    • JAEHNE G, LANG HJ, GLOMBIK H, GEISEN K et al.: In vivo anorectic activity of substituted tetrahydro-indeno[1,2-d]thiazols. 224th American Chemical Society Meeting, Boston, MA, USA (18 - 22 August 2002).
    • (2002) 224th American Chemical Society Meeting
    • JAEHNE, G.1    LANG, H.J.2    GLOMBIK, H.3    GEISEN, K.4
  • 9
    • 12444281769 scopus 로고    scopus 로고
    • + channel opener targeted for overactive bladder: Synthesis and structure-activity relationships of 2-amino-4-azaindoles
    • + channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles. Bioorg. Med. Chem. Lett. (2003) 13(12):2003-2007.
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , Issue.12 , pp. 2003-2007
    • TURNER, S.C.1    CARROLL, V.A.2    WHITE, T.K.3
  • 10
    • 2542623187 scopus 로고    scopus 로고
    • ATP opener that selectively inhibits spontaneous bladder contractions.
    • ATP opener that selectively inhibits spontaneous bladder contractions. J. Med. Chem. (2004) 47(12):3163-3179.
    • (2004) J. Med. Chem. , vol.47 , Issue.12 , pp. 3163-3179
    • CARROLL, W.A.1    ALTENBACH, R.J.2    BAI, H.3
  • 11
    • 0347360263 scopus 로고    scopus 로고
    • Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder
    • PEREZ-MEDRANO A, BUCKNER SA, COGHLAN MJ et al.: Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder. Bioorg. Med. Chem. Lett. (2004) 14(2):397-400.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , Issue.2 , pp. 397-400
    • PEREZ-MEDRANO, A.1    BUCKNER, S.A.2    COGHLAN, M.J.3
  • 12
    • 0347360263 scopus 로고    scopus 로고
    • Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder
    • PEREZ-MEDRANO A, BUCKNER SA, COGHLAN MJ et al.: Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder. Bioorg. Med. Chem. Lett. (2004) 14(2):397-400.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , Issue.2 , pp. 397-400
    • PEREZ-MEDRANO, A.1    BUCKNER, S.A.2    COGHLAN, M.J.3
  • 13
    • 12444281769 scopus 로고    scopus 로고
    • + channel opener targeted for overactive bladder: Synthesis and structure-activity relationships of 2-amino-4-azaindoles
    • + channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles. Bioorg. Med. Chem. Lett. (2003) 13(12):2003-2007.
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , Issue.12 , pp. 2003-2007
    • TURNER, S.C.1    CARROLL, W.A.2    WHITE, T.K.3
  • 16
    • 0037041186 scopus 로고    scopus 로고
    • The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (Maxi-K) channel opener targeted for urge urinary incontinence.
    • HEWAWASAM P, ERWAY M, THALODY G et al. The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (Maxi-K) channel opener targeted for urge urinary incontinence. Bioorg. Med. Chem. Lett. (2002) 12(7):1117-1120.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , Issue.7 , pp. 1117-1120
    • HEWAWASAM, P.1    ERWAY, M.2    THALODY, G.3
  • 17
    • 0032801232 scopus 로고    scopus 로고
    • + channel openers, KRN2391 and Ki1769, and nitroglycerine on the urinary tract of rats in vivo
    • + channel openers, KRN2391 and Ki1769, and nitroglycerine on the urinary tract of rats in vivo. Jpn. J. Pharmacol. (1999) 80(2):143-153.
    • (1999) Jpn. J. Pharmacol , vol.80 , Issue.2 , pp. 143-153
    • KONTANI, H.1    JINKAWA, M.2    SHIRAOYA, C.3    NAGASHIMA, A.4
  • 18
    • 0001799243 scopus 로고    scopus 로고
    • +-channels and suppresses micturition reflex in rats
    • +-channels and suppresses micturition reflex in rats. J. Urol. (1998) 159(Suppl. 5).
    • (1998) J. Urol , vol.159 , Issue.SUPPL. 5
    • TANAKA, M.1    SASAKI, Y.2    HUKUI, T.3
  • 19
    • 34447573838 scopus 로고    scopus 로고
    • American Urological Association - 95th Annual Meeting
    • 762-765
    • BRIONI JD, MORELAND RB: American Urological Association - 95th Annual Meeting. IDrug (2000) 3(7):762-765.
    • (2000) IDrug , vol.3 , Issue.7
    • BRIONI, J.D.1    MORELAND, R.B.2
  • 20
    • 0346119078 scopus 로고    scopus 로고
    • A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity
    • TANAKA M, SASAKI Y, KIMURA Y, FUKUI T, HAMADA K, UKAI Y: A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int. (2003) 92(9):1031-1036.
    • (2003) BJU Int , vol.92 , Issue.9 , pp. 1031-1036
    • TANAKA, M.1    SASAKI, Y.2    KIMURA, Y.3    FUKUI, T.4    HAMADA, K.5    UKAI, Y.6
  • 21
    • 0037047453 scopus 로고    scopus 로고
    • Effect of KW-7158, a putative afferent nerve inhibitor, on bladder and vesico-vascular reflexes in rats
    • LU SH, YAMAGATA T, ATSUKI K et al.: Effect of KW-7158, a putative afferent nerve inhibitor, on bladder and vesico-vascular reflexes in rats. Brain Res. (2002) 946(1):72-78.
    • (2002) Brain Res , vol.946 , Issue.1 , pp. 72-78
    • LU, S.H.1    YAMAGATA, T.2    ATSUKI, K.3
  • 22
    • 33645779772 scopus 로고    scopus 로고
    • Effect of an ATP-sensitive potassium channel opener in subjects with overactive bladder: A randomized, double-blind, placebo-controlled study (ZD0947IL/0004)
    • CHAPPLE C, PATRONEVA A, RAINES RS: Effect of an ATP-sensitive potassium channel opener in subjects with overactive bladder: a randomized, double-blind, placebo-controlled study (ZD0947IL/0004). Eur Urol. (2006) 49:879-886.
    • (2006) Eur Urol , vol.49 , pp. 879-886
    • CHAPPLE, C.1    PATRONEVA, A.2    RAINES, R.S.3
  • 23
    • 0034718839 scopus 로고    scopus 로고
    • Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-defident mice
    • COCKAYNE DA, HAMILTON SG, ZHU QM et al.: Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-defident mice. Nature (2000) 407:1011-1015.
    • (2000) Nature , vol.407 , pp. 1011-1015
    • COCKAYNE, D.A.1    HAMILTON, S.G.2    ZHU, Q.M.3
  • 24
    • 0035413364 scopus 로고    scopus 로고
    • G.P2X3 knock-out mice reveal a major sensory role for urothelially released ATP
    • VLASKOVSKA M, KASAKOV I, RONG W et al.: G.P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. (2001) 21:5670-5677.
    • (2001) J. Neurosci , vol.21 , pp. 5670-5677
    • VLASKOVSKA, M.1    KASAKOV, I.2    RONG, W.3
  • 25
    • 34447562761 scopus 로고    scopus 로고
    • Division of medicinal chemistry - P2 nucleotide receptors
    • KIBBLE A. Division of medicinal chemistry - P2 nucleotide receptors. IDrugs (2000) 3(11): 1270-1271.
    • (2000) IDrugs , vol.3 , Issue.11 , pp. 1270-1271
    • KIBBLE, A.1
  • 26
    • 0036897244 scopus 로고    scopus 로고
    • SSR240600 [(R)-2-1-[2-[4-[2-[3,5-bis(trifluoromethyl)-phenyl] acethyl-2-(3,4-(dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)- 2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor. I. biochemical and pharmacological characterization
    • EMONDS-ALX X, PROIETTO V, STEINBERG R et al.: SSR240600 [(R)-2-1-[2-[4-[2-[3,5-bis(trifluoromethyl)-phenyl] acethyl-2-(3,4-(dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)- 2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor. I. biochemical and pharmacological characterization. J. Pharmacol. Exp. Ther. (2002) 303 (3):1171-1179.
    • (2002) J. Pharmacol. Exp. Ther , vol.303 , Issue.3 , pp. 1171-1179
    • EMONDS-ALX, X.1    PROIETTO, V.2    STEINBERG, R.3
  • 27
    • 1642472928 scopus 로고    scopus 로고
    • Lower urinary tract disorders - Ray Fuller Symposium, physiology, pharmacology and therapeutic approaches
    • MICHEL MC: Lower urinary tract disorders - Ray Fuller Symposium, physiology, pharmacology and therapeutic approaches. IDrngs (2002) 5:792-796.
    • (2002) IDrngs , vol.5 , pp. 792-796
    • MICHEL, M.C.1
  • 28
    • 33750520115 scopus 로고    scopus 로고
    • Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence
    • GREEN SA, ALON A, IANUS J, MCNAUGHTON KS, TOZZI CA, REISS TF: Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence. J. Urol. (2006) 176:2535-2540.
    • (2006) J. Urol , vol.176 , pp. 2535-2540
    • GREEN, S.A.1    ALON, A.2    IANUS, J.3    MCNAUGHTON, K.S.4    TOZZI, C.A.5    REISS, T.F.6
  • 29
    • 0038209328 scopus 로고    scopus 로고
    • Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β(3) adrenergic receptor agonists
    • SUM FW, WONG V, HAN S, LARGIS E, MULVEY R, TILLETT J: Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β(3) adrenergic receptor agonists. Bioorg. Med. Chem. Lett. (2003) 13(13):2191-2194.
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , Issue.13 , pp. 2191-2194
    • SUM, F.W.1    WONG, V.2    HAN, S.3    LARGIS, E.4    MULVEY, R.5    TILLETT, J.6
  • 30
    • 34447564089 scopus 로고    scopus 로고
    • 3 adrenoceptor agonism decreases motility and induces anti-hyperalgesia: A novel target for IBS
    • 3 adrenoceptor agonism decreases motility and induces anti-hyperalgesia: a novel target for IBS. Gastroenterology (2006) 130(4 Suppl. 2).
    • (2006) Gastroenterology , vol.130 , Issue.4 SUPPL. 2
    • CELLEK, S.1    THANGIAH, R.2    BASSIL, A.K.3
  • 31
    • 34447576855 scopus 로고    scopus 로고
    • 3 adrenergic receptor agonist, evokes bladder relaxation and increases mictrurition reflex threshold in the dog. Abstracts of the American Urological Association Annual Meeting, San Antonio, Texas, USA (21 - 26 May 2005). J. Urol. (2005) 173(Suppl. 4):1-467.
    • 3 adrenergic receptor agonist, evokes bladder relaxation and increases mictrurition reflex threshold in the dog. Abstracts of the American Urological Association Annual Meeting, San Antonio, Texas, USA (21 - 26 May 2005). J. Urol. (2005) 173(Suppl. 4):1-467.
  • 33
    • 0033627045 scopus 로고    scopus 로고
    • Treatment of overactive bladder: Other drug mechanisms
    • ANDERSSON KE: Treatment of overactive bladder: other drug mechanisms. Urology (2000) 55:51-57.
    • (2000) Urology , vol.55 , pp. 51-57
    • ANDERSSON, K.E.1
  • 34
    • 20044371821 scopus 로고    scopus 로고
    • Human bladder as a novel target for vitamin D receptor ligands
    • CRESCIOLI C, MORELLI A, ADORINI L et al.: Human bladder as a novel target for vitamin D receptor ligands. J. Endocrinol. Metab. (2004) 90(2):962-972.
    • (2004) J. Endocrinol. Metab , vol.90 , Issue.2 , pp. 962-972
    • CRESCIOLI, C.1    MORELLI, A.2    ADORINI, L.3
  • 35
    • 84892040422 scopus 로고    scopus 로고
    • BXL-628, a vitamin D receptor antagonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder
    • In Press
    • MORELLI A. VIGNOZZI L, FILIPPI S et al.: BXL-628, a vitamin D receptor antagonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder. Prostate (2006) (In Press).
    • (2006) Prostate
    • MORELLI, A.1    VIGNOZZI, L.2    FILIPPI, S.3
  • 36
    • 0029962164 scopus 로고    scopus 로고
    • Preliminary evaluation of besipirdine for the treatment of Alzheimer's disease. Besipirdine study group
    • HUFF FJ: Preliminary evaluation of besipirdine for the treatment of Alzheimer's disease. Besipirdine study group. Ann. NY Acad Sci. (1996) 777:410-414.
    • (1996) Ann. NY Acad Sci , vol.777 , pp. 410-414
    • HUFF, F.J.1
  • 37
    • 33746873324 scopus 로고    scopus 로고
    • Patient-reported outcomes in overactive bladder: Importance for determining clinical effectiveness of treatment
    • BRUBAKER L, CHAPPLE C, COYNE KS, KOPP Z: Patient-reported outcomes in overactive bladder: importance for determining clinical effectiveness of treatment. Uroogy (2006) 68(Suppl. 2):3-8.
    • (2006) Uroogy , vol.68 , Issue.SUPPL. 2 , pp. 3-8
    • BRUBAKER, L.1    CHAPPLE, C.2    COYNE, K.S.3    KOPP, Z.4
  • 38
    • 0032538048 scopus 로고    scopus 로고
    • International group seeks to dispel incontinence "taboo
    • VOELKER R: International group seeks to dispel incontinence "taboo". JAMA (1998) 280:951.
    • (1998) JAMA , vol.280 , pp. 951
    • VOELKER, R.1
  • 39
    • 33645783025 scopus 로고    scopus 로고
    • Interview with Chris Chapple. Overactive bladder: Tackling the problem
    • CHAPPLE C: Interview with Chris Chapple. Overactive bladder: tackling the problem. Eur Urol. (2006) 49(5):921-923.
    • (2006) Eur Urol , vol.49 , Issue.5 , pp. 921-923
    • CHAPPLE, C.1
  • 40
    • 1142274243 scopus 로고    scopus 로고
    • Management of overactive bladder
    • OUSLANDER JG: Management of overactive bladder. N. Engl. J. Med. (2004) 350(8):786-799.
    • (2004) N. Engl. J. Med , vol.350 , Issue.8 , pp. 786-799
    • OUSLANDER, J.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.