The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation

Biomaterials

Volumn 32, Issue 7, 2011, Pages 1865-1871

  Kim, Jin Hyoung ^a   Kim, Myung Hun ^b   Jo, Dong Hyun ^a   Yu, Young Suk ^a   Lee, Tae Geol ^c   Kim, Jeong Hun ^a  

^a Seoul National University Hospital   (South Korea)

^b Yonsei University   (South Korea)

^c Korea Research Institute of Standards and Science   (South Korea)

Author keywords

ERK 1 2; Gold nanoparticle; Retinal microvascular endothelial cell; Retinal neovascularization; Vascular endothelial growth factor receptor 2

Indexed keywords

ERK 1/2; GOLD NANOPARTICLE; MICROVASCULAR ENDOTHELIAL CELLS; NEOVASCULARIZATION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR;

BLOOD VESSELS; DRUG THERAPY; EYE PROTECTION; GOLD; NANOPARTICLES; OPHTHALMOLOGY; PEPTIDES; PHOSPHORYLATION; SELF ASSEMBLY; TOXICITY;

ENDOTHELIAL CELLS;

GOLD NANOPARTICLE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; DRUG ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RETINA NEOVASCULARIZATION; RETROLENTAL FIBROPLASIA;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; GOLD; HUMANS; INFANT, NEWBORN; METAL NANOPARTICLES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; RETINOPATHY OF PREMATURITY; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

ANIMALIA;

EID: 78650996703     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.11.030     Document Type: Article

References (26)

1. Folkman J. Angiogenesis. Annu Rev Med 2006, 57:1-18.
2. Risau W. Mechanism of angiogenesis. Nature 1997, 386:671-674.
3. Gariano R.F., Gardner T.W. Retinal angiogenesis in development and disease. Nature 2005, 438:960-966.
4. Aiello L.P., Avery R.L., Arrigg P.G., Keyt B.A., Jampel H.D., Shah S.T., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994, 331:1480-1487.
5. Gibson D.L., Sheps S.B., Uh S.H., Schechter M.T., McCormick A.Q. Retinopathy of prematurity-induced blindness: birth weight-specific survival and the new epidemic. Pediatrics 1990, 86:405-412.
6. Chen J., Smith L.E. Retinopathy of prematurity. Angiogenesis 2007, 10:133-140.
7. Smith L.E., Wesolowski E., McLellan A., Kostyk S.K., D'Amato R., Sullivan R., et al. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994, 35:101-111.
8. Weis S.M., Cheresh D.A. Pathophysiological consequences of VEGF-induced vascular permeability. Nature 2005, 437:497-504.
9. Adams R.H., Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007, 8:464-478.
10. Shalaby F., Ho J., Stanford W.L., Fischer K.D., Schuh A.C., Schwartz L., et al. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 1997, 89:981-990.
11. Takahashi T., Yamaguchi S., Chida K., Shibuya M.A. Single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells. EMBO J 2001, 20:2768-2778.
12. Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Disc 2007, 6:274-286.
13. Mukherjee P., Bhattacharya R., Wang P., Wang L., Basu S., Nagy J.A., et al. Antiangiogenic properties of gold nanoparticles. Clin Cancer Res 2005, 11:3530-3534.
14. Kemp M.M., Kumar A., Mousa S., Dyskin E., Yalcin M., Ajayan P., et al. Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties. Nanotechnology 2009, 20:455104.
15. Kim J.H., Kim J.H., Kim K.W., Kim M.H., Yu Y.S. Intravenously administered gold nanoparticles pass through the blood-retinal barrier depending on the particle size, and induce no retinal toxicity. Nanotechnology 2009, 20:505101.
16. Kim J.H., Kim J.H., Yu Y.S., Shin J.Y., Lee H.Y., Kim K.W. Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy. J Cell Mol Med 2008, 12:2407-2415.
17. Kim J.H., Kim J.H., Yu Y.S., Park K.H., Kang H.J., Lee H.Y., et al. Anti-angiogenic effect of deguelin on choroidal neovascularization. J Pharmacol Exp Ther 2008, 324:643-647.
18. Min J.K., Cho Y.L., Choi J.H., Kim Y., Kim J.H., Yu Y.S., et al. Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice. Blood 2007, 109:1495-1502.
19. Kim J.H., Kim C., Kim J.H., Lee B.J., Yu Y.S., Park K.H., et al. Absence of intravitreal bevacizumab-induced neuronal toxicity in the retina. Neurotoxicology 2008, 29:1131-1135.
20. Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat Med 2003, 9:669-676.
21. Kim J.H., Kim J.H., Lee Y.M., Ahn E.M., Kim K.W., Yu Y.S. Decursin inhibits VEGF-mediated inner blood-retinal barrier breakdown by suppression of VEGFR-2 activation. J Cereb Blood Flow Metab 2009, 29:1559-1567.
22. Kim J.H., Kim J.H., Jun H.O., Yu Y.S., Kim K.W. Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. Am J Pathol 2010, 176:1517-1524.
23. Kim J.H., Kim J.H., Lee Y.M., Ahn E.M., Kim K.W., Yu Y.S. Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation. Mol Vis 2009, 15:1868-1875.
24. Kim J.H., Kim J.H., Yu Y.S., Cho C.S., Kim K.W. Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy. J Cereb Blood Flow Metab 2009, 29:621-628.
25. Johnson S.R., Evans S.D., Mahon S.W., Ulman A. Alkanethiol molecules containing an aromatic moiety self-assembled onto gold clusters. Langmuir 1997, 13:51-57.
26. Krilleke D., Ng Y.S., Shima D.T. The heparin-binding domain confers diverse functions of VEGF-A in development and disease: a structure-function study. Biochem Soc Trans 2009, 37:1201-1206.