An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

Blood

Volumn 117, Issue 1, 2011, Pages 283-289

  Castellino, Francis J ^a   Donahue, Deborah L ^a   Navari, Rudolph M ^b   Ploplis, Victoria A ^a   Walsh, Mark ^b,c  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c is an assistant professor of nursing at Bethel College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; PROTEIN C; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTOXEMIA; FEMALE; GENETIC DISORDER; INFLAMMATION; LETHALITY; MALE; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; SURVIVAL; THROMBOELASTOGRAPHY;

EID: 78650992099     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-07-299057     Document Type: Article

References (26)

1. Steinemann S, Ulevitch RJ, Mackman N. Role of the lipopolysaccharide (LPS)-binding protein/CD14 pathway in LPS induction of tissue factor expression in monocytic cells. Arterioscler Thromb. 1994;14(7):1202-1209.
2. Drake TA, Cheng J, Chang A, DeBault LE. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol. 1993;142(5):1458-1470.
3. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407(6801):258-264.
4. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344(10):699-709.
5. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007;109(8):3161-3172.
6. Danese S, Vetrano S, Zhang L, Ploplis VA, Castellino FJ. The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood. 2010;115(6):1121-1140.
7. Marlar RA, Neumann A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies. Semin Thromb Hemost. 1990;16(4):299-309.
8. Jalbert LR, Rosen ED, Moons L, et al. Inactivation of the gene for anticoagulant Protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest. 1998;102(8):1481-1488. (Pubitemid 28492214)
9. Lay AJ, Zhong L, Rosen ED, Castellino FJ. Mice with a severe deficiency of Protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest. 2005;115(6):1552-1556.
10. Lay AJ, Northway CM, Donahue DL, Castellino FJ. Low levels of tissue factor rescue protein C-associated pregnancy failure in mice. J Thromb Haemost. 2008;6(10):1815-1817.
11. Gu JM, Crawley JT, Ferrell G, et al. Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality. J Biol Chem. 2002;277(45):43335-43343. (Pubitemid 35285721)
12. Healy AM, Rayburn HB, Rosenberg RD,Weiler H. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A. 1995;92(3):850-854.
13. Li W, Zheng X, Gu JM, et al. Extraembryonic expression of EPCR is essential for embryonic viability. Blood. 2005;106(8):2716-2722.
14. Isermann B, Sood R, Pawlinski R, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med. 2003;9(3):331-337.
15. Parry GC, Erlich JH, Carmeliet P, Luther T, Mackman N. Low levels of tissue factor are compatible with development and hemostasis in mice. J Clin Invest. 1998;101(3):560-569.
16. Ploplis VA, Wilberding J, McLennan L, et al. A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am J Pathol. 2000;157(3):703-708.
17. Lay AJ, Donahue D, Tsai MJ, Castellino FJ. Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood. 2007;109(5):1884-1891.
18. Landskroner KA, Olson NC, Jesmok GJ. Thromboelastography measurements of whole blood from factor VIII-deficient mice supplemented with rFVIII. Haemophilia. 2005;11(4):346-352.
19. Pawlinski R, Pedersen B, Schabbauer G, et al. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood. 2004;103(4):1342-1347.
20. Xu H, Ploplis VA, Castellino FJ. A coagulation factor VII deficiency protects against acute inflammatory responses in mice. J Pathol. 2006;210(4):448-496.
21. Carraway MS, Welty-Wolf KE, Miller DL, et al. Blockade of tissue factor: treatment for organ injury in established sepsis. Am J Respir Crit Care Med. 2003;167(9):1200-1209.
22. Kashuk JL, Moore EE, Le T, et al. Noncitrated whole blood is optimal for evaluation of postinjury coagulopathy with point-of-care rapid thrombelastography. J Surg Res. 2009;156(1):133-138.
23. Bune LT, Thaning P, Johansson PI, Bochsen L, Rosenmeier JB. Effects of nucleotides and nucleosides on coagulation. Blood Coagul Fibrinolysis. 2010;21(5):436-441.
24. White NJ, Martin EJ, Brophy DF, Ward KR. Co-agulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation. Resuscitation. 2010;81(1):111-116.
25. Viuff D, Andersen S, Sørensen BB, Lethagen S. Optimizing thrombelastography (TEG) assay conditions to monitor rFVIIa (NovoSeven) therapy in haemophilia A patients. Thromb Res. 2010;126(2):144-149.
26. Yaguchi A, Lobo FL, Vincent JL, Pradier O. Platelet function in sepsis. J Thromb Haemost. 2004;2(12):2096-2102.