Rapid and sensitive drug metabolism studies by SU-8 microchip capillary electrophoresis-electrospray ionization mass spectrometry

Journal of Chromatography A

Volumn 1218, Issue 5, 2011, Pages 739-745

  Nordman, Nina ^a   Sikanen, Tiina ^a   Moilanen, Maria Elisa ^a   Aura, Susanna ^b   Kotiaho, Tapio ^a   Franssila, Sami ^b   Kostiainen, Risto ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b AALTO UNIVERSITY   (Finland)

Author keywords

Electrophoresis; Epoxy photoresist SU 8; Mass spectrometry; Metabolism; Microfluidics

Indexed keywords

DETECTION SENSITIVITY; DRUG METABOLISMS; ELECTROPHORETIC SEPARATIONS; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; EPOXY PHOTORESIST SU-8; INTERNAL STANDARDS; LIQUID PHASE MICROEXTRACTION; METABOLIC PROFILING; MICROCHIP CAPILLARY ELECTROPHORESIS; MODEL REACTIONS; MONOLITHICALLY INTEGRATED; OFF-CHIP; ON CHIPS; OXIDATION PRODUCTS; PARACETAMOL; PHASE I; PHASE II; SAMPLE PRETREATMENT; SHEATH FLOWS; SOLID-PHASE EXTRACTION; TRAMADOL; URINE SAMPLE; VERSATILE TOOLS;

BIOMOLECULES; BODY FLUIDS; CAPILLARY ELECTROPHORESIS; ELECTROCHEMISTRY; ELECTROSPRAY IONIZATION; ENZYME KINETICS; ENZYMES; HYDROXYLATION; IONIZATION; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; MICROFLUIDICS; MICROPROCESSOR CHIPS; MONOLITHIC INTEGRATED CIRCUITS; PHOTORESISTS; SOLVENT EXTRACTION;

METABOLISM;

1 HYDROXYBUFURALOL; BUFURALOL; CYTOCHROME P450; DRUG METABOLITE; PARACETAMOL; POLYMER; TRAMADOL; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CONJUGATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; LIQUID PHASE MICROEXTRACTION; MICROCHIP ELECTROPHORESIS; NORMAL HUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE MICROEXTRACTION; URINALYSIS; VOLUNTEER;

ACETAMINOPHEN; ACETATES; CHEMICAL FRACTIONATION; ELECTROPHORESIS, MICROCHIP; EPOXY COMPOUNDS; ETHANOLAMINES; HUMANS; METHANOL; MODELS, CHEMICAL; POLYMERS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRAMADOL;

EID: 78650957643     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.12.010     Document Type: Article

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