Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids

Journal of Lipid Research

Volumn 52, Issue 1, 2011, Pages 98-103

  Afonyushkin, Taras ^a   Oskolkova, Olga V ^a   Binder, Bernd R ^a   Bochkov, Valery N ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Angiogenesis; NF E2 related factor 2; Oxidized lipids; Vascular endothelial growth factor

Indexed keywords

CASEIN KINASE II; CASEIN KINASE IIALPHA; CASEIN KINASE IIBETA; PHOSPHOLIPID; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; ATF4 GENE; CONTROLLED STUDY; ELECTROPHILIC STRESS; ENDOTHELIUM CELL; GCLM GENE; GENE; GENE ACTIVATION; HMOX1 GENE; HUMAN; HUMAN CELL; NQO1 GENE; PRIORITY JOURNAL; UPREGULATION; VEGF GENE;

ACTIVATING TRANSCRIPTION FACTOR 4; CASEIN KINASE II; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE SILENCING; HUMANS; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXYGEN; PHOSPHOLIPIDS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78650903532     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M009480     Document Type: Article

References (29)

1. Bochkov , V. N. , O. V. Oskolkova , K. G. Birukov , A. L. Levonen , C. J. Binder , and J. Stockl . 2010 . Generation and biological activities of oxidized phospholipids. Antioxid. Redox Signal. 12 : 1009-1059.
2. Gargalovic , P. S. , N. M. Gharavi , M. J. Clark , J. Pagnon , W. P. Yang , A. He , A. Truong , T. Baruch-Oren , J. A. Berliner , and T. G. Kirchgessner , et al . 2006 . The unfolded protein response is an important regulator of infl ammatory genes in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 26 : 2490-2496.
3. Jyrkkanen , H. K. , E. Kansanen , M. Inkala , A. M. Kivela , H. Hurttila , S. E. Heinonen , G. Goldsteins , S. Jauhiainen , S. Tiainen , and H. Makkonen , et al . 2008 . Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ. Res. 103 : e1-e9.
4. Nguyen , T. , P. J. Sherratt , P. Nioi , C. S. Yang , and C. B. Pickett . 2005 . Nrf2 controls constitutive and inducible expression of AREdriven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. J. Biol. Chem. 280 : 32485-32492.
5. Cullinan , S. B. , D. Zhang , M. Hannink , E. Arvisais , R. J. Kaufman , and J. A. Diehl . 2003 . Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 : 7198-7209.
6. Lee , J. M. , J. M. Hanson , W. A. Chu , and J. A. Johnson . 2001 . Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J. Biol. Chem. 276 : 20011-20016.
7. Martin , D. , A. I. Rojo , M. Salinas , R. Diaz , G. Gallardo , J. Alam , C. M. De Galarreta , and A. Cuadrado . 2004 . Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/ Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J. Biol. Chem. 279 : 8919-8929.
8. Apopa , P. L. , X. He , and Q. Ma . 2008 . Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J. Biochem. Mol. Toxicol. 22 : 63-76.
9. Pi , J. , Y. Bai , J. M. Reece , J. Williams , D. Liu , M. L. Freeman , W. E. Fahl , D. Shugar , J. Liu , W. Qu , et al . 2007 . Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free Radic. Biol. Med. 42 : 1797-1806.
10. Kadl , A. , J. Huber , F. Gruber , V. N. Bochkov , B. R. Binder , and N. Leitinger . 2002 . Analysis of infl ammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS. Vascul. Pharmacol. 38 : 219-227.
11. Gargalovic , P. S. , M. Imura , B. Zhang , N. M. Gharavi , M. J. Clark , J. Pagnon , W. P. Yang , A. He , A. Truong , S. Patel , et al . 2006 . Identifi cation of infl ammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc. Natl. Acad. Sci. U S A . 103 : 12741-12746.
12. Afonyushkin , T. , O. V. Oskolkova , M. Philippova , T. J. Resink , P. Erne , B. R. Binder , and V. N. Bochkov . 2010 . Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler. Thromb. Vasc. Biol. 30 : 1007-1013.
13. Bochkov , V. N. , M. Philippova , O. Oskolkova , A. Kadl , A. Furnkranz , E. Karabeg , T. Afonyushkin , F. Gruber , J. Breuss , A. Minchenko , et al . 2006 . Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions. Circ. Res. 99 : 900-908.
14. Oskolkova, O. V. , T. Afonyushkin , A. Leitner , E. von Schlieffen , P. S. Gargalovic , A. J. Lusis , B. R. Binder , and V. N. Bochkov . 2008 . ATF4- dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response. Blood . 112 : 330-339.
15. Watson , A. D. , N. Leitinger , M. Navab , K. F. Faull , S. Horkko , J. L. Witztum , W. Palinski , D. Schwenke , R. G. Salomon , W. Sha , et al . 1997 . Structural identifi cation by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J. Biol. Chem. 272 : 13597-13607.
16. Broekhuyse , R. M. 1968 . Phospholipids in tissues of the eye. I. Isolation, characterization and quantitative analysis by two-dimensional thin-layer chromatography of diacyl and vinyl-ether phospholipids. Biochim. Biophys. Acta . 152 : 307-315.
17. Baker , A. , M. Saltik , H. Lehrmann , I. Killisch , V. Mautner , G. Lamm , G. Christofori , and M. Cotten . 1997 . Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery. Gene Ther. 4 : 773-782.
18. Garbin , U. , P. A. Fratta , C. Stranieri , M. Cominacini , A. Pasini , S. Manfro , F. Lugoboni , C. Mozzini , G. Guidi , G. Faccini , et al . 2009 . Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring infl ammation. PLoS ONE . 4 : e8225.
19. Li , R. , W. Chen , R. Yanes , S. Lee , and J. A. Berliner . 2007 . OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. J. Lipid Res. 48 : 709-715.
20. Birukova , A. A. , P. Fu , S. Chatchavalvanich , D. Burdette , O. Oskolkova , V. N. Bochkov , and K. G. Birukov . 2007 . Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium. Am. J. Physiol. Lung Cell. Mol. Physiol. 292 : L924-L935.
21. Cole , A. L. , G. Subbanagounder , S. Mukhopadhyay , J. A. Berliner , and D. K. Vora . 2003 . Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. Arterioscler. Thromb. Vasc. Biol. 23 : 1384-1390.
22. Iwasaki , K. , Y. Miwa , M. Haneda , K. Uchida , A. Nakao , and T. Kobayashi . 2010 . Signifi cance of HLA class I antibody-induced antioxidant gene expression for endothelial cell protection against complement attack. Biochem. Biophys. Res. Commun. 391 : 1210-1215.
23. Nakaso , K. , H. Yano , Y. Fukuhara , T. Takeshima , K. Wada-Isoe , and K. Nakashima . 2003 . PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett. 546 : 181-184.
24. Zhang , Y. , L. Guan , X. Wang , T. Wen , J. Xing , and J. Zhao . 2008 . Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. Free Radic. Res. 42 : 362-371.
25. Davies , S. P. , H. Reddy , M. Caivano , and P. Cohen . 2000 . Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 : 95-105.
26. Subbanagounder , G. , N. Leitinger , D. C. Schwenke , J. W. Wong , H. Lee , C. Rizza , A. D. Watson , K. F. Faull , A. M. Fogelman , and J. A. Berliner . 2000 . Determinants of bioactivity of oxidized phospholipids. specific oxidized fatty acyl groups at the sn-2 position. Arterioscler. Thromb. Vasc. Biol. 20 : 2248-2254.
27. Boon , R. A. , and A. J. Horrevoets . 2009 . Key transcriptional regulators of the vasoprotective effects of shear stress. Hamostaseologie . 29 : 39-43.
28. Lau , A. , N. F. Villeneuve , Z. Sun , P. K. Wong , and D. D. Zhang . 2008 . Dual roles of Nrf2 in cancer. Pharmacol. Res. 58 : 262-270.
29. Ruzzene , M. , and L. A. Pinna . 2010 . Addiction to protein kinase CK2: a common denominator of diverse cancer cells? Biochim. Biophys. Acta . 1804 : 499-504.