메뉴 건너뛰기




Volumn 51, Issue 12, 2010, Pages 811-818

Beta3-adrenoceptor agonists: Possible role in the treatment of overactive bladder

Author keywords

Adrenergic beta agonists; Afferent pathways; Overactive; Urinary bladder

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRANOLOL; CATECHOLAMINE; DOBUTAMINE; ISOPRENALINE; MESSENGER RNA; MIRABEGRON; NITRIC OXIDE; PLACEBO; PROCATEROL; RECEPTOR SUBTYPE; SOLABEGRON; TOLTERODINE;

EID: 78650897515     PISSN: 20056737     EISSN: 20056745     Source Type: Journal    
DOI: 10.4111/kju.2010.51.12.811     Document Type: Review
Times cited : (58)

References (48)
  • 2
    • 61349178824 scopus 로고    scopus 로고
    • The beta3-adrenoceptor as a therapeutic target: Current perspectives
    • Ursino MG, Vasina V, Raschi E, Crema F, De Ponti F. The beta3-adrenoceptor as a therapeutic target: current perspectives. Pharmacol Res 2009;59:221-34.
    • (2009) Pharmacol Res , vol.59 , pp. 221-234
    • Ursino, M.G.1    Vasina, V.2    Raschi, E.3    Crema, F.4    De Ponti, F.5
  • 4
    • 0017365232 scopus 로고
    • Characterization of the adrenergic beta receptor in the urinary bladder of man and cat
    • Nergardh A, Boreus LO, Naglo AS. Characterization of the adrenergic beta-receptor in the urinary bladder of man and cat. Acta Pharmacol Toxicol 1977;40:14-21. (Pubitemid 8015345)
    • (1977) Acta Pharmacologica et Toxicologica , vol.40 , Issue.1 , pp. 14-21
    • Nergardh, A.1    Boreus, L.O.2    Naglo, A.S.3
  • 5
    • 0018426271 scopus 로고
    • Alpha and beta-adrenoceptors in the detrusor muscle and bladder base of the pig and beta-adrenoceptors in the detrusor muscle of man
    • Larsen JJ. Alpha and beta-adrenoceptors in the detrusor muscle and bladder base of the pig and beta-adrenoceptors in the detrusor muscle of man. Br J Pharmacol 1979;65:215-22.
    • (1979) Br J Pharmacol , vol.65 , pp. 215-222
    • Larsen, J.J.1
  • 6
    • 0033625191 scopus 로고    scopus 로고
    • 3-adrenoceptors in rat, rabbit and human urinary bladder and external urethral sphincter
    • Morita T, Iizuka H, Iwata T, Kondo S. Function and distribution of beta3-adrenoceptors in rat, rabbit and human urinary bladder and external urethral sphincter. J Smooth Muscle Res 2000;36:21-32. (Pubitemid 30365869)
    • (2000) Journal of Smooth Muscle Research , vol.36 , Issue.1 , pp. 21-32
    • Morita, T.1    Iizuka, H.2    Iwata, T.3    Kondo, S.4
  • 7
    • 0031450659 scopus 로고    scopus 로고
    • Characterization of beta-adrenoceptors in urinary bladder: Comparison between rat and rabbit
    • DOI 10.1038/sj.bjp.0701562
    • Oshita M, Hiraoka Y, Watanabe Y. Characterization of beta-adrenoceptors in urinary bladder: comparison between rat and rabbit. Br J Pharmacol 1997;122:1720-4. (Pubitemid 28000200)
    • (1997) British Journal of Pharmacology , vol.122 , Issue.8 , pp. 1720-1724
    • Oshita, M.1    Hiraoka, Y.2    Watanabe, Y.3
  • 8
    • 0031748658 scopus 로고    scopus 로고
    • Species differences in the distribution of beta-adrenoceptor subtypes in bladder smooth muscle
    • Yamazaki Y, Takeda H, Akahane M, Igawa Y, Nishizawa O, Ajisawa Y. Species differences in the distribution of beta-adrenoceptor subtypes in bladder smooth muscle. Br J Pharmacol 1998;124:593-9.
    • (1998) Br J Pharmacol , vol.124 , pp. 593-599
    • Yamazaki, Y.1    Takeda, H.2    Akahane, M.3    Igawa, Y.4    Nishizawa, O.5    Ajisawa, Y.6
  • 9
    • 0032775379 scopus 로고    scopus 로고
    • Pharmacological characterization of beta-adrenoceptors mediating relaxation of the rat urinary bladder in vitro
    • Longhurst PA, Levendusky M. Pharmacological characterization of beta-adrenoceptors mediating relaxation of the rat urinary bladder in vitro. Br J Pharmacol 1999;127:1744-50.
    • (1999) Br J Pharmacol , vol.127 , pp. 1744-1750
    • Longhurst, P.A.1    Levendusky, M.2
  • 10
    • 0038507052 scopus 로고    scopus 로고
    • Functional characterization of beta-adrenoceptor subtypes in the canine and rat lower urinary tract
    • Takeda H, Matsuzawa A, Igawa Y, Yamazaki Y, Kaidoh K, Akahane S, et al. Functional characterization of beta-adrenoceptor subtypes in the canine and rat lower urinary tract. J Urol 2003;170:654-8.
    • (2003) J Urol , vol.170 , pp. 654-658
    • Takeda, H.1    Matsuzawa, A.2    Igawa, Y.3    Yamazaki, Y.4    Kaidoh, K.5    Akahane, S.6
  • 12
    • 0030928350 scopus 로고    scopus 로고
    • Structure and function of the beta 3-adrenergic receptor
    • Strosberg AD. Structure and function of the beta 3-adrenergic receptor. Annu Rev Pharmacol Toxicol 1997;37:421-50.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 421-450
    • Strosberg, A.D.1
  • 13
    • 0030273411 scopus 로고    scopus 로고
    • Function and regulation of the beta 3-adrenoceptor
    • Strosberg AD, Pietri-Rouxel F. Function and regulation of the beta 3-adrenoceptor. Trends Pharmacol Sci 1996;17:373-81.
    • (1996) Trends Pharmacol Sci , vol.17 , pp. 373-381
    • Strosberg, A.D.1    Pietri-Rouxel, F.2
  • 15
    • 0033074328 scopus 로고    scopus 로고
    • Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle
    • Fujimura K, Tamura K, Tsutsumi T, Yamamoto T, Nakamura K, Koibuchi Y, et al. Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle. J Urol 1999;161:680-5.
    • (1999) J Urol , vol.161 , pp. 680-685
    • Fujimura, K.1    Tamura, K.2    Tsutsumi, T.3    Yamamoto, T.4    Nakamura, K.5    Koibuchi, Y.6
  • 16
    • 0032588710 scopus 로고    scopus 로고
    • Evidence for beta3-adrenoceptor subtypes in relaxation of the human urinary bladder detrusor: Analysis by molecular biological and pharmacological methods
    • Takeda M, Obara K, Mizusawa T, Tomita Y, Arai K, Tsutsui T, et al. Evidence for beta3-adrenoceptor subtypes in relaxation of the human urinary bladder detrusor: analysis by molecular biological and pharmacological methods. J Pharmacol Exp Ther 1999;288:1367-73.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1367-1373
    • Takeda, M.1    Obara, K.2    Mizusawa, T.3    Tomita, Y.4    Arai, K.5    Tsutsui, T.6
  • 17
    • 0037830662 scopus 로고    scopus 로고
    • A quantitative analysis of mRNA expression of alpha 1 and beta-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders
    • Nomiya M, Yamaguchi O. A quantitative analysis of mRNA expression of alpha 1 and beta-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders. J Urol 2003;170:649-53.
    • (2003) J Urol , vol.170 , pp. 649-653
    • Nomiya, M.1    Yamaguchi, O.2
  • 18
    • 35148847913 scopus 로고    scopus 로고
    • Beta3-adrenoceptors in urinary bladder
    • Yamaguchi O, Chapple CR. Beta3-adrenoceptors in urinary bladder. Neurourol Urodyn 2007;26:752-6.
    • (2007) Neurourol Urodyn , vol.26 , pp. 752-756
    • Yamaguchi, O.1    Chapple, C.R.2
  • 19
    • 32544437708 scopus 로고    scopus 로고
    • Alpha1-, alpha2- And beta-adrenoceptors in the urinary bladder, urethra and prostate
    • Michel MC, Vrydag W. Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 2006;147(Suppl 2):S88-119.
    • (2006) Br J Pharmacol , vol.147 , Issue.SUPPL. 2
    • Michel, M.C.1    Vrydag, W.2
  • 22
    • 0034749291 scopus 로고    scopus 로고
    • Relaxant effects of isoproterenol and selective beta3-adrenoceptor agonists on normal, low compliant and hyperreflexic human bladders
    • Igawa Y, Yamazaki Y, Takeda H, Kaidoh K, Akahane M, Ajisawa Y, et al. Relaxant effects of isoproterenol and selective beta3-adrenoceptor agonists on normal, low compliant and hyperreflexic human bladders. J Urol 2001;165:240-4.
    • (2001) J Urol , vol.165 , pp. 240-244
    • Igawa, Y.1    Yamazaki, Y.2    Takeda, H.3    Kaidoh, K.4    Akahane, M.5    Ajisawa, Y.6
  • 23
    • 0034131308 scopus 로고    scopus 로고
    • Role of the beta(3)-adrenoceptor in urine storage in the rat: Comparison between the selective beta(3)-adrenoceptor agonist, CL316, 243,and various smooth muscle relaxants
    • Takeda H, Yamazaki Y, Akahane M, Igawa Y, Ajisawa Y, Nishizawa O. Role of the beta(3)-adrenoceptor in urine storage in the rat: comparison between the selective beta(3)-adrenoceptor agonist, CL316, 243,and various smooth muscle relaxants. J Pharmacol Exp Ther 2000;293:939-45.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 939-945
    • Takeda, H.1    Yamazaki, Y.2    Akahane, M.3    Igawa, Y.4    Ajisawa, Y.5    Nishizawa, O.6
  • 24
    • 0036707581 scopus 로고    scopus 로고
    • Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats
    • Kaidoh K, Igawa Y, Takeda H, Yamazaki Y, Akahane S, Miyata H, et al. Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats. J Urol 2002;168:1247-52.
    • (2002) J Urol , vol.168 , pp. 1247-1252
    • Kaidoh, K.1    Igawa, Y.2    Takeda, H.3    Yamazaki, Y.4    Akahane, S.5    Miyata, H.6
  • 25
    • 0034742117 scopus 로고    scopus 로고
    • Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat
    • Woods M, Carson N, Norton NW, Sheldon JH, Argentieri TM. Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat. J Urol 2001;166:1142-7. (Pubitemid 32751059)
    • (2001) Journal of Urology , vol.166 , Issue.3 , pp. 1142-1147
    • Woods, M.1    Carson, N.2    Norton, N.W.3    Sheldon, J.H.4    Argentieri, T.M.5
  • 26
    • 0036400318 scopus 로고    scopus 로고
    • Effects of beta(3)-adrenoceptor stimulation on prostaglandin E(2)-induced bladder hyperactivity and on the cardiovascular system in conscious rats
    • Takeda H, Yamazaki Y, Igawa Y, Kaidoh K, Akahane S, Miyata H, et al. Effects of beta(3)-adrenoceptor stimulation on prostaglandin E(2)-induced bladder hyperactivity and on the cardiovascular system in conscious rats. Neurourol Urodyn 2002;21:558-65.
    • (2002) Neurourol Urodyn , vol.21 , pp. 558-565
    • Takeda, H.1    Yamazaki, Y.2    Igawa, Y.3    Kaidoh, K.4    Akahane, S.5    Miyata, H.6
  • 27
    • 45749103234 scopus 로고    scopus 로고
    • Effects of the beta 3-adrenergic receptor agonist disodium 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino] propyl]-1,3- benzodioxole-2,2-dicarboxylate (CL-316243) on bladder micturition reflex in spontaneously hypertensive rats
    • Leon LA, Hoffman BE, Gardner SD, Laping NJ, Evans C, Lashinger ES, et al. Effects of the beta 3-adrenergic receptor agonist disodium 5-[(2R)-2-[[(2R)-2- (3-chlorophenyl)-2-hydroxyethyl]amino] propyl]-1,3-benzodioxole-2,2- dicarboxylate (CL-316243) on bladder micturition reflex in spontaneously hypertensive rats. J Pharmacol Exp Ther 2008;326:178-85.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 178-185
    • Leon, L.A.1    Hoffman, B.E.2    Gardner, S.D.3    Laping, N.J.4    Evans, C.5    Lashinger, E.S.6
  • 28
    • 0034185336 scopus 로고    scopus 로고
    • Discussion: Functional role of M(1), M(2), and M(3) muscarinic receptors in overactive bladder
    • Igawa Y. Discussion: functional role of M(1), M(2), and M(3) muscarinic receptors in overactive bladder. Urology 2000;55(5A Suppl):47-9.
    • (2000) Urology , vol.55 , Issue.5 A SUPPL. , pp. 47-49
    • Igawa, Y.1
  • 29
    • 34547130566 scopus 로고    scopus 로고
    • Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder
    • Ehlert FJ, Ahn S, Pak KJ, Park GJ, Sangnil MS, Tran JA, et al. Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder. J Pharmacol Exp Ther 2007;322:631-7.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 631-637
    • Ehlert, F.J.1    Ahn, S.2    Pak, K.J.3    Park, G.J.4    Sangnil, M.S.5    Tran, J.A.6
  • 30
    • 34247205378 scopus 로고    scopus 로고
    • Effect of (R)-2-(2-aminothiazol-4-yl)-4′-{2-[(2-hydroxy-2- phenylethyl) amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function
    • Takasu T, Ukai M, Sato S, Matsui T, Nagase I, Maruyama T, et al. Effect of (R)-2-(2-aminothiazol-4-yl)-4′-{2-[(2-hydroxy-2-phenylethyl) amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function. J Pharmacol Exp Ther 2007;321:642-7.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 642-647
    • Takasu, T.1    Ukai, M.2    Sato, S.3    Matsui, T.4    Nagase, I.5    Maruyama, T.6
  • 31
    • 23644445651 scopus 로고    scopus 로고
    • Involvement of cyclic AMP-dependent and -independent mechanisms in the relaxation of rat detrusor muscle via beta-adrenoceptors
    • Uchida H, Shishido K, Nomiya M, Yamaguchi O. Involvement of cyclic AMP-dependent and -independent mechanisms in the relaxation of rat detrusor muscle via beta-adrenoceptors. Eur J Pharmacol 2005;518:195-202.
    • (2005) Eur J Pharmacol , vol.518 , pp. 195-202
    • Uchida, H.1    Shishido, K.2    Nomiya, M.3    Yamaguchi, O.4
  • 32
  • 34
    • 0037107129 scopus 로고    scopus 로고
    • Beta -adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells
    • Birder LA, Nealen ML, Kiss S, de Groat WC, Caterina MJ, Wang E, et al. Beta -adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci 2002;22:8063-70.
    • (2002) J Neurosci , vol.22 , pp. 8063-8070
    • Birder, L.A.1    Nealen, M.L.2    Kiss, S.3    De Groat, W.C.4    Caterina, M.J.5    Wang, E.6
  • 36
    • 77955556872 scopus 로고    scopus 로고
    • The β3-adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome
    • Masunaga K, Chapple CR, McKay NG, Yoshida M, Sellers DJ. The β3-adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome. Neurourol Urodyn 2010;29:1320-5.
    • (2010) Neurourol Urodyn , vol.29 , pp. 1320-1325
    • Masunaga, K.1    Chapple, C.R.2    McKay, N.G.3    Yoshida, M.4    Sellers, D.J.5
  • 37
    • 76049104146 scopus 로고    scopus 로고
    • Distribution of beta-adrenoceptor subtypes in suburothelial interstitial cells in the human urinary bladder
    • abstract 225
    • Otsuka A, Matsumoto R, Shinbo H, Imanishi T, Kurita Y, Ozono S. Distribution of beta-adrenoceptor subtypes in suburothelial interstitial cells in the human urinary bladder. Nueouro Urodyn 2009;28(Suppl):871-2, abstract 225.
    • (2009) Nueouro Urodyn , vol.28 , Issue.SUPPL. , pp. 871-872
    • Otsuka, A.1    Matsumoto, R.2    Shinbo, H.3    Imanishi, T.4    Kurita, Y.5    Ozono, S.6
  • 39
    • 77955557104 scopus 로고    scopus 로고
    • Effects of CL316,243, a beta 3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat
    • Aizawa N, Igawa Y, Nishizawa O, Wyndaele JJ. Effects of CL316,243, a beta 3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat. Neurourol Urodyn 2010;29:771-6.
    • (2010) Neurourol Urodyn , vol.29 , pp. 771-776
    • Aizawa, N.1    Igawa, Y.2    Nishizawa, O.3    Wyndaele, J.J.4
  • 43
    • 0038071650 scopus 로고    scopus 로고
    • Orally bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type-II diabetes
    • Hu B, Jennings LL. Orally bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type-II diabetes. Prog Med Chem 2003;41:167-94.
    • (2003) Prog Med Chem , vol.41 , pp. 167-194
    • Hu, B.1    Jennings, L.L.2
  • 44
    • 34548840602 scopus 로고    scopus 로고
    • GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog
    • Hicks A, McCafferty GP, Riedel E, Aiyar N, Pullen M, Evans C, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther 2007;323:202-9.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 202-209
    • Hicks, A.1    McCafferty, G.P.2    Riedel, E.3    Aiyar, N.4    Pullen, M.5    Evans, C.6
  • 45
    • 33750891388 scopus 로고    scopus 로고
    • The effects of a new selective beta3-adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder
    • Biers SM, Reynard JM, Brading AF. The effects of a new selective beta3-adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder. BJU Int 2006;98:1310-4.
    • (2006) BJU Int , vol.98 , pp. 1310-1314
    • Biers, S.M.1    Reynard, J.M.2    Brading, A.F.3
  • 46
    • 78650855419 scopus 로고    scopus 로고
    • www.clinicaltrials.gov
  • 47
    • 47149090579 scopus 로고    scopus 로고
    • Clinical proof of concept study (Blossom) shows novel β3 adrenoceptor agonist YM178 is effective and well tolerated in the treatment of symptoms of overactive bladder
    • Chapple CR, Yamaguchi O, Ridder A, Liehne J, Carl S, Mattiasson A, et al. Clinical proof of concept study (Blossom) shows novel β3 adrenoceptor agonist YM178 is effective and well tolerated in the treatment of symptoms of overactive bladder. Eur Urol 2008;(Suppl 7):239.
    • (2008) Eur Urol , Issue.SUPPL. 7 , pp. 239
    • Chapple, C.R.1    Yamaguchi, O.2    Ridder, A.3    Liehne, J.4    Carl, S.5    Mattiasson, A.6
  • 48
    • 78650910571 scopus 로고    scopus 로고
    • Dose-ranging study of once-daily mirabegron (YM178), a novel selective β3-adrenoceptor agonist, in patients with overactive bladder (OAB)
    • Chapple C, Wyndaele JJ, van Kerrebroeck P, Radziszewski P, Dvorak V, Boerrigter P. Dose-ranging study of once-daily mirabegron (YM178), a novel selective β3-adrenoceptor agonist, in patients with overactive bladder (OAB). Eur Urol 2010;(Suppl 9):249.
    • (2010) Eur Urol , Issue.SUPPL. 9 , pp. 249
    • Chapple, C.1    Wyndaele, J.J.2    Van Kerrebroeck, P.3    Radziszewski, P.4    Dvorak, V.5    Boerrigter, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.