Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat

Journal of Urology

Volumn 166, Issue 3, 2001, Pages 1142-1147

  Woods, Morgan ^a   Carson, Nancyleigh ^a   Norton, N Wesley ^a   Sheldon, Jeffrey H ^a   Argentieri, Thomas M ^a  

^a WYETH AYERST RESEARCH   (United States)

Author keywords

Adrenergic agonists; Bladder; Rats, Sprague Dawley

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 3 ADRENERGIC RECEPTOR; 1,3 DIOXOLANE DERIVATIVE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER OBSTRUCTION; CONTROLLED STUDY; CYTOMETRY; DEPOLARIZATION; DETRUSOR DYSSYNERGIA; ELECTROSTIMULATION; HYPERREFLEXIA; MALE; MICTURITION; MUSCLE CONTRACTION; NEUROGENIC BLADDER; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; TISSUE CULTURE; URINE INCONTINENCE; ANIMAL; BLADDER DISEASE; DRUG EFFECT; PATHOLOGICAL REFLEX; PATHOPHYSIOLOGY; SMOOTH MUSCLE; SPRAGUE DAWLEY RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; DIOXOLES; MALE; MUSCLE, SMOOTH; RATS; RATS, SPRAGUE-DAWLEY; REFLEX, ABNORMAL; URINARY BLADDER DISEASES;

EID: 0034742117     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65936-8     Document Type: Article

References (37)

1. Urinary incontinence
2. Beta-adrenoceptor subtypes in the detrusor of guinea-pig urinary bladder
3. Characterization of the adrenergic beta-receptor in the urinary bladder of man and cat
4. Identification of receptor subtypes in the rabbit and human urinary bladder by selective radio-ligand binding
5. Modulation by beta-adrenoreceptors of spontaneous contractions of rat urinary bladder
6. Characterization of functional beta-adrenoceptor subtypes in rabbit urinary bladder smooth muscle
7. Species differences in the distribution of beta-adrenoceptor subtypes in bladder smooth muscle
8. Characterization of beta-adrenoceptors in urinary bladder: Comparison between rat and rabbit
9. Expression of beta3-adrenoceptors in rat detrusor smooth muscle
10. Pharmacological characterization of beta-adrenoceptors mediating relaxation of the rat urinary bladder in vitro
11. Functional and molecular biological evidence for a possible beta3-adrenoceptor in the human detrusor muscle
12. Possible beta 3-adrenoceptor-mediated relaxation of the human detrusor
13. Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle
14. Evidence for beta3-adrenoceptor subtypes in relaxation of the human urinary bladder detrusor: Analysis by molecular biological and pharmacological methods
15. Role of the beta(3)-adrenoceptor in urine storage in the rat: Comparison between the selective beta(3)-adrenoceptor agonist, CL316,243, and various smooth muscle relaxants
16. Effect of an atypical adrenergic beta3-agonist, GS-332: Sodium (2R)-[3-[3-[2-(3-chlorophenyl)-2-hydroxyethylamino] cyclohexyl] phenoxy] acetate, on urinary bladder function in rats
17. Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat
18. Cystometrical evalation of bladder instability in rats with infravesical outflow obstruction
19. Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and in vivo bladder instability in rat
20. Oxybutinin versus propantheline in the management of detrusor instability. A patient-regulated variable dose trial
21. Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability
22. Dry mouth with conventional and controlled-release oxybutynin in urinary incontinence
23. Alpha and beta-adrenoceptors in the detrusor muscle and bladder base of the pig and beta-adrenoceptors in the detrusor muscle of man
24. Alterations in G-proteins and β-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging
25. Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines
26. Involvement of BKCa channels in the relaxation of detrusor muscle via β-adrenoceptors
27. Alterations in afferent pathways from the urinary bladder of the rat in response to partial urethral obstruction
28. Bladder afferent pathway and spinal cord injury: Possible mechanisms inducing hyperreflexia of the urinary bladder
29. Comparisons of neurotransmitter concentrations in the synaptosomal preparation of the normotensive and hypertensive rat urinary bladder
30. Neurally mediated hyperactive voiding in spontaneously hypertensive rats
31. Efferent and afferent neuronal hypertrophy associated with micturition pathways in spontaneously hypertensive rats
32. The effect of cromakalim on the normal and hyper-reflexic human detrusor muscle
33. Effects of pinacidil on detrusor instability in men with bladder outlet obstruction
34. The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions
35. Interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists
36. Functional beta3-adrenoceptor in the human heart
37. The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle