The β3-Adrenoceptor mediates the inhibitory effects of β-Adrenoceptor agonists via the urothelium in pig bladder dome

Neurourology and Urodynamics

Volumn 29, Issue 7, 2010, Pages 1320-1325

  Masunaga, Koichi ^a   Chapple, Christopher R ^b   McKay, Neil G ^a   Yoshida, Masaki ^c   Sellers, Donna J ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

adrenoceptor agonist; adrenoceptor antagonist; Mucosa; Pig bladder; Urothelium

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARBACHOL; DOBUTAMINE; ISOPRENALINE; PROPRANOLOL; SALBUTAMOL;

ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER CONTRACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; INHIBITION KINETICS; NONHUMAN; OVERACTIVE BLADDER; SMOOTH MUSCLE RELAXATION; SWINE; UROTHELIUM;

ADRENERGIC BETA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MUSCLE CONTRACTION; MUSCLE RELAXATION; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; SWINE; URINARY BLADDER; UROTHELIUM;

EID: 77955556872     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.20838     Document Type: Article

References (21)

1. Frazier EP, Mathy M, Peters SL, et al. Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol? J Pharmacol Exp Ther 2005; 313:260-267
2. Lands AM, Luduena FP, Buzzo HJ. Differentiation of receptors responsive to isoproterenol. Life Sci 1967;6:2241-2249
3. Emorine LJ, Blin N, Strosberg AD. The human b3-adrenoceptor: The search for a physiological function. Trends Pharmacol Sci 1994;15:3-7.
4. Maggi CA, Meli A. Modulation by b-adrenoreceptors of spontaneous contractions of rat urinary bladder. J Auton Pharmacol 1982;2:255-260
5. Levin RM, Ruggieri MR, Wein AJ. Identification of receptor subtypes in the rabbit and human urinary bladder by selective radio-ligand binding. J Urol 1988;139:844-848
6. Morita T, Ando M, Kihara K, et al. Species differences in cAMP production and contractile response induced by beta-adrenoceptor subtypes in urinary bladder smooth muscle. Neurourol Urodyn 1993;12:185-190
7. Yamanishi T, Chapple CR, Yasuda K, et al.. The role of beta3-adrenoceptors in mediating relaxation of porcine detrusor muscle. Br J Pharmacol 2002; 135:129-134
8. Nomiya M, Yamaguchi O. A quantitative analysis of mRNA expression of α1 and β-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders. J Urol 2003;170:649-653
9. Igawa Y, Yamazaki Y, Takeda H, et al. Relaxant effects of isoproterenol and selective beta3-adrenoceptor agonists on normal, low compliant and hyperreflexic human bladders. J Urol 2001;165:240-244
10. Andersson KE, Chapple C, Wein A. The basis for drug treatment of the overactive bladder. World J Urol 2001;19:294-298
11. Badawi JK, Seja T, Uecelehan H, et al. Relaxation of human detrusor muscle by selective beta-2 and beta-3 agonists and endogenous catecholamines. Urology 2007;69:785-790
12. 3- adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder. BJU Int 2006;98:1310-1314
13. Harmon EB, Porter JM, Porter JE. β-adrenergic receptor activation in immortalized human urothelial cell stimulates inflammatory responses by PKA-independent mechanisms. Cell Commun Signal 2005; 3:10-21.
14. Birder LA, Nealen ML, Kiss S, et al. β-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci 2002;22:8063-8070
15. Murakami S, Chapple CR, Akino H, et al. The role of the urothelium in mediating bladder responses to isoprenaline. BJU Int 2007;99: 669-673
16. Hawthorn MH, Chapple CR, Cock M, et al. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 2000;129:416-419
17. Templeman L, Chapple CR, Chess-Williams R. Urothelium derived inhibitory factor and cross-talk among receptors in the trigone of the bladder of the pig. J Urol 2002;167:742-745
18. Chaiyaprasithi B, Mang CF, Kilbinger H, et al. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol 2003;170:1897-1900
19. Otsuka A, Shinbo H, Matsumoto R, et al. Expression and functional role of b-adrenoceptors in the human urinary bladder urothelium. Naunyn- Scmiedeberg's Arch Pharmacol 2008;377:474-481
20. Levin RM, Wein AJ, Krasnopolsky L, et al. Effect of mucosal removal on the response of the feline bladder to pharmacological stimulation. J Urol 1995; 153:1291-1294
21. Yoshida M, Inadome A, Maeda Y, et al. Non-neuronal cholinergic system in human bladder urothelium. Urology 2006;67:425-430