Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density

Breast Cancer Research

Volumn 12, Issue 4, 2010, Pages

  Haakensen, Vilde D ^a,b   Biong, Margarethe ^a   Lingjærde, Ole C ^c   Holmen, Marit M ^a   Frantzen, Jan O ^d   Chen, Ying ^e   Navjord, Dina ^f   Romundstad, Linda ^g   Lüders, Torben ^h   Bukholm, Ida K ^b,i   Solvang, Hiroko K ^a   Kristensen, Vessela N ^a,b,h   Ursin, Giske ^c,j   Børresen Dale, Anne Lise ^a,b   Helland, Åslaug ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^e VESTFOLD HOSPITAL TRUST   (Norway)

^f Innlandet Hospital   (Norway)

^g Sykehuset Buskerud HF   (Norway)

^h AKERSHUS UNIVERSITY HOSPITAL   (Norway)

ⁱ Akerhus University Hospital   (Norway)

^j UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; GENE PRODUCT; GLUCURONOSYLTRANSFERASE; ISOENZYME; UGT2B10 PROTEIN, HUMAN;

ADULT; ARTICLE; BREAST BIOPSY; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; CORRELATION COEFFICIENT; DENSITY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOTYPE; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; LINEAR REGRESSION ANALYSIS; MAMMOGRAPHY; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PREDICTIVE VALIDITY; PROTEIN EXPRESSION; RECEPTOR GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; BIOPSY; BREAST; BREAST TUMOR; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MIDDLE AGED; PARITY; PATHOLOGY; PREGNANCY; STATISTICAL MODEL;

BIOPSY; BREAST; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; LINEAR MODELS; MAMMOGRAPHY; MIDDLE AGED; PARITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RISK FACTORS;

EID: 78650890357     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2632     Document Type: Article

References (43)

1. Oza AM, Boyd NF. Mammographic parenchymal patterns: a marker of breast cancer risk. Epidemiol Rev 1993, 15:196-208.
2. Boyd NF, Byng JW, Jong RA, Fishell EK, Little LE, Miller AB, Lockwood GA, Tritchler DL, Yaffe MJ. Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study. J Natl Cancer Inst 1995, 87:670-675. 10.1093/jnci/87.9.670, 7752271.
3. Ursin G, Ma H, Wu AH, Bernstein L, Salane M, Parisky YR, Astrahan M, Siozon CC, Pike MC. Mammographic density and breast cancer in three ethnic groups. Cancer Epidemiol Biomarkers Prev 2003, 12:332-338.
4. Boyd NF, Lockwood GA, Martin LJ, Knight JA, Byng JW, Yaffe MJ, Tritchler DL. Mammographic densities and breast cancer risk. Breast Dis 1998, 10:113-126.
5. Guo YP, Martin LJ, Hanna W, Banerjee D, Miller N, Fishell E, Khokha R, Boyd NF. Growth factors and stromal matrix proteins associated with mammographic densities. Cancer Epidemiol Biomarkers Prev 2001, 10:243-248.
6. Ursin G, Lillie EO, Lee E, Cockburn M, Schork NJ, Cozen W, Parisky YR, Hamilton AS, Astrahan MA, Mack T. The relative importance of genetics and environment on mammographic density. Cancer Epidemiol Biomarkers Prev 2009, 18:102-112. 10.1158/1055-9965.EPI-07-2857, 19124487.
7. Guillemette C, Levesque E, Harvey M, Bellemare J, Menard V. UGT genomic diversity: beyond gene duplication. Drug Metab Rev 2010, 42(1):22-42. 10.3109/03602530903210682, 19857043.
8. Mackenzie PI, Gregory PA, Lewinsky RH, Yasmin SN, Height T, McKinnon RA, Gardner-Stephen DA. Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases. Toxicol Appl Pharmacol 2005, 207:77-83. 10.1016/j.taap.2004.12.026, 15979674.
9. Cheng Z, Rios GR, King CD, Coffman BL, Green MD, Mojarrabi B, Mackenzie PI, Tephly TR. Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Toxicol Sci 1998, 45:52-57.
10. Yong M, Schwartz SM, Atkinson C, Makar KW, Thomas SS, Newton KM, iello Bowles EJ, Holt VL, Leisenring WM, Lampe JW. Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States. Cancer Epidemiol Biomarkers Prev 2010, 19:537-546. 10.1158/1055-9965.EPI-09-0898, 20142249.
11. Starlard-Davenport A, Lyn-Cook B, Radominska-Pandya A. Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues. Steroids 2008, 73:611-620. 2408449, 18374377, 10.1016/j.steroids.2008.01.019.
12. Wang H, Karesen R, Hervik A, Thoresen SO. Mammography screening in Norway: results from the first screening round in four counties and cost-effectiveness of a modeled nationwide screening. Cancer Causes Control 2001, 12:39-45. 10.1023/A:1008999403069, 11227924.
13. Stanford Microarray Database. , http://genome-www5.stanford.edu//
14. R library impute.knn. , http://rss.acs.unt.edu/Rdoc/library/impute/html/impute.knn.html
15. Gunderson KL, Steemers FJ, Lee G, Mendoza LG, Chee MS. A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet 2005, 37:549-554. 10.1038/ng1547, 15838508.
16. Nordgard SH, Johansen FE, Alnaes GI, Bucher E, Syvanen AC, Naume B, Borresen-Dale AL, Kristensen VN. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. Genes Chromosomes Cancer 2008, 47:680-696. 10.1002/gcc.20569, 18398821.
17. Sequenom. , http://www.sequenom.com/
18. Ursin G, Astrahan MA, Salane M, Parisky YR, Pearce JG, Daniels JR, Pike MC, Spicer DV. The detection of changes in mammographic densities. Cancer Epidemiol Biomarkers Prev 1998, 7:43-47.
19. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98:5116-5121. 33173, 11309499, 10.1073/pnas.091062498.
20. Significance Analysis of Microarrays. , http://www-stat.stanford.edu/~tibs/SAM/
21. R project. , http://r-project.org
22. Altman DG. Practical Statistics for Medical Research 1999, Boca Raton: Chapman & Hall/CRC.
23. Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 2009, 27:1160-1167. 2667820, 19204204, 10.1200/JCO.2008.18.1370.
24. Carlborg O, de Koning DJ, Manly KF, Chesler E, Williams RW, Haley CS. Methodological aspects of the genetic dissection of gene expression. Bioinformatics 2005, 21:2383-2393. 10.1093/bioinformatics/bti241, 15613385.
25. UNC Biostatistics Software Links. , http://www.bios.unc.edu/~wsun/software.htm
26. DAVID Bioinformatics Resources 6.7. , http://david.abcc.ncifcrf.gov/
27. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de RM, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lønning P, Børresen-Dale AL. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98:10869-10874. 58566, 11553815, 10.1073/pnas.191367098.
28. Nicolau M, Tibshirani R, Borresen-Dale AL, Jeffrey SS. Disease-specific genomic analysis: identifying the signature of pathologic biology. Bioinformatics 2007, 23:957-965. 10.1093/bioinformatics/btm033, 17277331.
29. Yang WT, Lewis MT, Hess K, Wong H, Tsimelzon A, Karadag N, Cairo M, Wei C, Meric-Bernstam F, Brown P, Arun B, Hortobagyi GN, Sahin A, Chang JC. Decreased TGFbeta signaling and increased COX2 expression in high risk women with increased mammographic breast density. Breast Cancer Res Treat 2010, 119(2):305-314. 10.1007/s10549-009-0350-0, 19241157.
30. Guillemette C, Belanger A, Lepine J. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res 2004, 6:246-254. 1064083, 15535854, 10.1186/bcr936.
31. Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. Mol Pharmacol 2007, 72:761-768. 10.1124/mol.107.037093, 17576790.
32. Dalhoff K, Buus JK, Enghusen PH. Cancer and molecular biomarkers of phase 2. Methods Enzymol 2005, 400:618-627. 10.1016/S0076-6879(05)00035-2, 16399374.
33. Verheus M, Maskarinec G, Erber E, Steude JS, Killeen J, Hernandez BY, Cline JM. Mammographic density and epithelial histopathologic markers. BMC Cancer 2009, 9:182. 2709637, 19523235, 10.1186/1471-2407-9-182.
34. Li T, Sun L, Miller N, Nicklee T, Woo J, Hulse-Smith L, Tsao MS, Khokha R, Martin L, Boyd N. The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiol Biomarkers Prev 2005, 14:343-349. 10.1158/1055-9965.EPI-04-0490, 15734956.
35. Rayter Z. Steroid receptors in breast cancer. Br J Surg 1991, 78:528-535. 10.1002/bjs.1800780506, 2059798.
36. Dunbier AK, Anderson H, Ghazoui Z, Folkerd EJ, A'hern R, Crowder RJ, Hoog J, Smith IE, Osin P, Nerurkar A, Parker JS, Perou CM, Ellis MJ, Dowsett M. Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women. J Clin Oncol 2010, 28:1161-1167. 10.1200/JCO.2009.23.9616, 20124184.
37. Cheng G, Li Y, Omoto Y, Wang Y, Berg T, Nord M, Vihko P, Warner M, Piao YS, Gustafsson JA. Differential regulation of estrogen receptor (ER)alpha and ERbeta in primate mammary gland. J Clin Endocrinol Metab 2005, 90:435-444. 10.1210/jc.2004-0861, 15507513.
38. Saji S, Jensen EV, Nilsson S, Rylander T, Warner M, Gustafsson JA. Estrogen receptors alpha and beta in the rodent mammary gland. Proc Natl Acad Sci USA 2000, 97:337-342. 26664, 10618419, 10.1073/pnas.97.1.337.
39. Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. Pharmacogenet Genomics 2008, 18:181-191. 10.1097/FPC.0b013e3282f4dbdd, 18300939.
40. Perou CM, Sorlie T, Eisen MB, van de RM, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature 2000, 406:747-752. 10.1038/35021093, 10963602.
41. Chen DT, Nasir A, Culhane A, Venkataramu C, Fulp W, Rubio R, Wang T, Agrawal D, McCarthy SM, Gruidl M, Bloom G, Anderson T, White J, Quackenbush J, Yeatman T. Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat 2010, 119(2):335-346. 10.1007/s10549-009-0344-y, 19266279.
42. Showe MK, Vachani A, Kossenkov AV, Yousef M, Nichols C, Nikonova EV, Chang C, Kucharczuk J, Tran B, Wakeam E, Yie TA, Speicher D, Rom WN, Albelda S, Showe LC. Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease. Cancer Res 2009, 69(24):9202-9210. 10.1158/0008-5472.CAN-09-1378, 19951989.
43. Jones C, Mackay A, Grigoriadis A, Cossu A, Reis-Filho JS, Fulford L, Dexter T, Davies S, Bulmer K, Ford E, Parry S, Budroni M, Palmieri G, Neville AM, O'Hare MJ, Lakhani SR. Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer. Cancer Res 2004, 64:3037-3045. 10.1158/0008-5472.CAN-03-2028, 15126339.