Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines

Pharmacogenetics and Genomics

Volumn 18, Issue 3, 2008, Pages 181-191

  Chen, Gang ^a,b   Dellinger, Ryan W ^b   Gallagher, Carla J ^b   Sun, Dongxiao ^b   Lazarus, Philip ^a,b  

^a PENN STATE CANCER INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

4 (methylnitrosamino) 1 (3 pyridyl) 1 butane; Haplotype; Liver; Polymorphism; Tobacco specific nitrosamines; UDP glucuronosyltransferase; UGT2B10

Indexed keywords

[4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL]; COMPLEMENTARY DNA; GLUCURONOSYLTRANSFERASE 2B10; GLYCOSYLTRANSFERASE; NITROSAMINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER SUSCEPTIBILITY; DNA POLYMORPHISM; GENE INACTIVATION; GENETIC ANALYSIS; GENETIC IDENTIFICATION; GENOTYPE; GLUCURONIDATION; HAPLOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TOBACCO;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA, COMPLEMENTARY; GLUCURONOSYLTRANSFERASE; HAPLOTYPES; HUMANS; LIVER; MUTATION, MISSENSE; NEOPLASMS; NITROSAMINES; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINANT PROTEINS; SMOKING; TOBACCO;

NICOTIANA TABACUM;

EID: 40049105052     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3282f4dbdd     Document Type: Article

References (31)